Administrative Core

管理核心摘要 拟议的研究评估迷走神经兴奋和解剖联系（REVEAL）中心旨在对迷走神经刺激（VNS）对四个关键系统的影响进行开创性研究：自主神经系统，心血管系统，免疫系统和代谢系统。这项雄心勃勃的研究范围需要八个主要学术和医疗机构的参与，其中包括40多名参与的关键人员，140多名患者，一个外部咨询委员会（包括患者倡导者），一个NIH指导委员会和其他NIH人员。因此，一个计划良好、组织良好、人员配备齐全的管理核心对于协调众多REVEAL利益相关者至关重要，以便中心能够实现其目标并为新的VNS研究和基于VNS的新疗法提供基础数据。REVEAL的管理核心将由明尼苏达大学（UMN）的两位医学科学家领导，他们拥有丰富的科学专业知识和领导多学科团队的丰富经验：约翰奥斯本博士（REVEAL Director），自主神经系统专家和明尼苏达州自主神经调节协会（Minnesota Consortium for Autonomic Neuromodulation）主任，以及Sayeed Ikramuddin博士（Reveal MPI），UMN外科主任，临床研究员和外科医生，具有代谢组学终点干预临床试验设计经验。管理核心的主要目标是促进核心和辅助项目之间的互动，以最大限度地提高REVEAL的生产力;协调所有REVEAL会议，包括年度VESPA会议;确保项目/核心PI，NIH和外部团体之间的沟通渠道清晰;管理REVEAL预算和财务。

ADMINISTRATION CORE Abstract The proposed Research Evaluating Vagal Excitation and Anatomical Linkages (REVEAL) center aims to conduct groundbreaking research on the effect of vagal nerve stimulation (VNS) on four key systems: the autonomic nervous system, the cardiovascular system, the immune system, and the metabolic system. The ambitious scope of the research requires the participation of eight major academic and medical institutions with over 40 participating key personnel, over 140 patients, an External Advisory Board (which includes patient advocates), and an NIH Steering Committee and other NIH personnel. As such, a well-planned, well-organized, and well- staffed Administration Core is crucial to coordinate the many REVEAL stakeholders so that the center can achieve its goals and produce foundational data for new VNS research and new VNS-based therapies. The Administration Core for REVEAL will be led by two medical scientists from the University of Minnesota (UMN) who have complimentary scientific expertise and extensive experience leading multidisciplinary teams: Dr. John Osborn (REVEAL Director), an expert in the autonomic nervous system and the director of the Minnesota Consortium for Autonomic Neuromodulation, and Dr. Sayeed Ikramuddin (Reveal MPI), Head of the UMN Department of Surgery and a clinical researcher and surgeon with experience in clinical trial design of interventions on metabolomic endpoints. The main goals of the Administration Core are to facilitate interactions between the Cores and Ancillary Projects to maximize REVEAL’s productivity; coordinate all REVEAL meetings, including an Annual VESPA Meeting; ensure clear lines of communication between Project/Core PIs, the NIH, and external groups; and manage the REVEAL budget and finances.