Administrative Core

行政核心

• 批准号: 10610557
• 负责人: John W Osborn
• 金额: $ 25.26万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610557
• 关键词: Advocate; Anatomy; Autonomic nervous system; Budgets; Calendar; Cardiovascular system; Clinical; Clinical Research; Clinical Trials Design; Collaborations; Communication; Complex; Contracts; Data; Ensure; Event; Feedback; Foundations; Future; Goals; Head; Health Insurance Portability and Accountability Act; Human Resources; Immune system; Institution; Link; Medical; Metabolic; Minnesota; Nerve; Newsletter; Operative Surgical Procedures; Patients; Productivity; Reporting; Research; Research Personnel; Scientist; Secure; Surgeon; System; Time; Transfer Agreement; United States National Institutes of Health; Universities; Update; base; data exchange; experience; interest; journal article; meetings; member; metabolomics; multidisciplinary; neuroregulation; participant enrollment; payment; therapy design; web site

ADMINISTRATION CORE Abstract The proposed Research Evaluating Vagal Excitation and Anatomical Linkages (REVEAL) center aims to conduct groundbreaking research on the effect of vagal nerve stimulation (VNS) on four key systems: the autonomic nervous system, the cardiovascular system, the immune system, and the metabolic system. The ambitious scope of the research requires the participation of eight major academic and medical institutions with over 40 participating key personnel, over 140 patients, an External Advisory Board (which includes patient advocates), and an NIH Steering Committee and other NIH personnel. As such, a well-planned, well-organized, and well- staffed Administration Core is crucial to coordinate the many REVEAL stakeholders so that the center can achieve its goals and produce foundational data for new VNS research and new VNS-based therapies. The Administration Core for REVEAL will be led by two medical scientists from the University of Minnesota (UMN) who have complimentary scientific expertise and extensive experience leading multidisciplinary teams: Dr. John Osborn (REVEAL Director), an expert in the autonomic nervous system and the director of the Minnesota Consortium for Autonomic Neuromodulation, and Dr. Sayeed Ikramuddin (Reveal MPI), Head of the UMN Department of Surgery and a clinical researcher and surgeon with experience in clinical trial design of interventions on metabolomic endpoints. The main goals of the Administration Core are to facilitate interactions between the Cores and Ancillary Projects to maximize REVEAL’s productivity; coordinate all REVEAL meetings, including an Annual VESPA Meeting; ensure clear lines of communication between Project/Core PIs, the NIH, and external groups; and manage the REVEAL budget and finances.

管理核心摘要 提出的评估迷走神经激发和解剖联系（揭示）中心的研究旨在对迷走神经刺激（VNS）对四个关键系统的影响进行开创性研究：自主神经系统，心血管系统，免疫系统，免疫系统和代谢系统。雄心勃勃的研究范围要求八个主要的学术和医疗机构参与，有40多名参与的关键人员，140多名患者，外部顾问委员会（包括患者倡导者）以及NIH指导委员会和其他NIH人员。因此，一个精心计划，组织良好且人工良好的管理核心对于协调许多揭示的利益相关者至关重要，因此中心可以实现其目标并为新的VNS研究和新的基于VNS的疗法生成基础数据。明尼苏达大学（UMN）的两名医学科学家将领导揭露的管理核心，他们拥有免费的科学专业知识和丰富的经验领导多学科团队：约翰·奥斯本（John Osborn）博士（揭露董事），自主神经系统的专家，明尼苏达州的主任，明尼苏达州的主任Minnesota instrormic and suryeeed suryermicatiental and Sayeed ikramuddin and umpi and um the umpi and umpidin（umpi and umpidin），研究人员和外科医生在代谢组终点的干预措施临床试验设计方面具有经验。管理核心的主要目标是促进核心和辅助项目之间的互动，以最大程度地提高揭示生产力；协调所有揭示会议，包括年度VESPA会议；确保项目/核心PI，NIH和外部组之间的清晰通信；并管理揭示预算和财务。