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Selection and Association in Coalescent Genealogies

Selection and Association in Coalescent Genealogies
合并谱系中的选择和关联
批准号:
6678518
负责人:
Mary K Kuhner
金额:
$45.45万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-01-01 至 2007-08-31

项目摘要

项目成果

Mary K Kuhner的其他基金

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中文摘要
翻译
描述(由申请人提供):本提案开发软件工具,使用马尔可夫链蒙特卡罗(MCMC)最大似然方法从遗传数据中推断种群参数。我们专注于推断选择,并将已知性状和未知的选择影响映射到特定的染色体区域。我们将开发以下方面的新技术:
英文摘要
DESCRIPTION (provided by applicant): This proposal develops software tools, which use Markov Chain Monte Carlo (MCMC) maximum-likelihood methods to infer population parameters from genetic data. We focus specifically on inferring selection and on mapping both known traits and unknown selective influences to specific chromosomal regions. We will develop new techniques for the following: (1) Estimating the presence and strength of natural selection and the degree of dominance, including statistical tests to compare selection hypotheses. (2) Mapping the location of a measured trait, or of a selection effect, relative to markers on a haplotype. (3) Mining the large sample of genealogies produced by MCMC algorithms for information such as the location of recombination hotspots, the time of significant events such as disease-locus mutations, and the overall time distribution of migration, mutation and recombination events. (4) Improving performance of MCMC algorithms via better search strategies and use of multiple computers in parallel. (5) Incorporating analysis of serial samples (samples taken from a population at different times) in order to strengthen estimation of selection and population growth. We will create freely distributed software implementing these methods and will test them using real and simulated data.
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Scaling up coalescent linkage disequilibrium mapping
  • 批准号:
    8069362
  • 项目类别:
  • 资助金额:
    $42.87万
  • 财政年份:
    2009
  • 负责人:
    Mary K Kuhner
  • 依托单位:
Scaling up coalescent linkage disequilibrium mapping
  • 批准号:
    7895063
  • 项目类别:
  • 资助金额:
    $43.34万
  • 财政年份:
    2009
  • 负责人:
    Mary K Kuhner
  • 依托单位:
Scaling up coalescent linkage disequilibrium mapping
  • 批准号:
    7561283
  • 项目类别:
  • 资助金额:
    $42.5万
  • 财政年份:
    2009
  • 负责人:
    Mary K Kuhner
  • 依托单位:
PHYLOGENIES of Barrett's Esophagus Lineages
海外基金