X-inactivation Related to Sex Differences in the Brain

X 失活与大脑性别差异相关

• 批准号: 6725388
• 负责人: JUN XU
• 金额: $ 7.63万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6725388
• 关键词: age difference; biological polymorphism; developmental neurobiology; gender difference; gene expression; gene induction /repression; heart; hormone regulation /control mechanism; kidney; laboratory mouse; liver; neurogenetics; neurophysiology; northern blottings; nucleic acid purification; phenotype; polymerase chain reaction; sex chromosomes; western blottings

DESCRIPTION (provided by applicant): The proposed studies have two long-term goals: (1) to understand the molecular signals that initiate sexually dimorphic development of the brain, and (2) to understand the forces that balance and regulate X chromosome gene expression in brain. Most sex differences in the brain are currently attributed to the action of gonadal steroid hormones. This concept needs to be modified, however, based on recent information suggesting that some X chromosome genes are expressed at a higher level in the female brain and may contribute to sex differences in brain development. The present application aims to determine whether a group of brain-related X-linked genes are sexually dimorphic in their expression, and to determine if the sex differences in expression are predicted by the X-inactivation status of each gene measured in the brain itself. The proposed research will contribute significantly to an understanding of the principles of sexual differentiation of the brain, including the molecular mechanisms by which male and female brains differ. The research will also help explain abnormalities of sexual differentiation, as well as sex differences in neurological and psychiatric disease (e.g., mental retardation).

描述（由申请人提供）：拟议的研究有两个长期目标：（1）了解启动大脑性二态发育的分子信号，以及（2）了解平衡和调节大脑中X染色体基因表达的力量。 大脑中的大多数性别差异目前被归因于性腺类固醇激素的作用。 然而，这一概念需要修改，根据最近的信息表明，一些X染色体基因在女性大脑中以更高的水平表达，可能有助于大脑发育的性别差异。 本申请旨在确定一组脑相关的X连锁基因在其表达中是否具有性别二态性，并确定表达中的性别差异是否通过在脑本身中测量的每个基因的X失活状态来预测。 这项拟议中的研究将大大有助于理解大脑性别分化的原理，包括男性和女性大脑不同的分子机制。 这项研究还将有助于解释性分化的异常，以及神经和精神疾病的性别差异（例如，智力迟钝）。