Neurocognition in Children At Risk for Bipolar Disorder

有双相情感障碍风险的儿童的神经认知

• 批准号: 6685872
• 负责人: PAULA K SHEAR
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-01 至 2005-10-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6685872
• 关键词: adolescence (12-20); behavioral /social science research tag; bipolar depression; child behavior; clinical research; cognition; cognition disorders; genetic susceptibility; human morbidity; human subject; mood disorders; neurophysiology; neuropsychological tests; neuropsychology; parents; quality of life; teacher

DESCRIPTION (provided by applicant): This revised NIMH Small Grant (R03) Award application is to support a preliminary investigation of executive functioning ability in children genetically at risk to develop bipolar disorder (BPD). BPD in children and adolescents is increasingly recognized as a common disorder with significant morbidity and mortality. It has been suggested that children with BPD may have a strong genetic vulnerability to develop this disorder and also may exhibit a particularly virulent form of the disorder. In addition to their mood symptoms, there is strong evidence that patients with BPD demonstrate cognitive dysfunction. Furthermore, a small number of reports suggest that cognitive deficits are evident in adults and children who are at genetic risk for BPD but who, at the time of evaluation, have not developed mood syndromes. Cognitive deficits are of direct clinical relevance because they are known to be associated with impairment in completing activities required for successful everyday functioning, including academic and vocational activities. In addition, cognitive dysfunction in individuals who are genetically at risk for BPD has strong theoretical importance because it may provide information about inherited features of mood syndromes, inform theories about the neurophysiological basis of mood disorders, and may potentially be evaluated in the future as one marker that could contribute to the early detection of individuals who are at the strongest risk of developing BPD. Previous work from our laboratory suggests that children at genetic risk for BPD have executive functioning deficits, including impairment in planning, problem-solving, and inhibition. The proposed study will compare the abilities of at-risk children who have mood syndromes, at-risk children without mood syndromes, and a control group of children of parents without a mood disorder on tests of specific component processes of executive functioning. A secondary aim of the study is examine, through parent and teacher ratings, whether children at risk for BPD with and without mood syndromes exhibit impairment in activities of daily living that are thought to be dependent on the integrity of executive functioning skills, and to examine the relationship between these functional deficits and performance on neuropsychological tests of executive ability.

描述（由申请人提供）：此修订的NIMH小额赠款（R03）奖申请是为了支持在遗传上有发展双相情感障碍（BPD）风险的儿童的执行功能能力的初步调查。儿童和青少年的BPD越来越被认为是一种常见的疾病，具有显著的发病率和死亡率。有人认为，患有BPD的儿童可能具有很强的遗传易感性，容易患上这种疾病，并且还可能表现出这种疾病的特别致命的形式。除了他们的情绪症状外，有强有力的证据表明BPD患者表现出认知功能障碍。此外，少数报告表明，认知缺陷在有BPD遗传风险的成人和儿童中是明显的，但在评估时，没有发展出情绪综合征。认知缺陷具有直接的临床相关性，因为已知它们与完成成功的日常功能所需的活动（包括学术和职业活动）的障碍有关。此外，认知功能障碍在遗传上有BPD风险的个体中具有很强的理论重要性，因为它可以提供有关情绪综合征的遗传特征的信息，告知有关情绪障碍的神经生理学基础的理论，并可能在未来作为一种标志物进行评估，这可能有助于早期检测处于发展BPD风险最高的个体。我们实验室以前的工作表明，有BPD遗传风险的儿童有执行功能缺陷，包括计划，解决问题和抑制方面的障碍。拟议的研究将比较有情绪综合征的高危儿童，没有情绪综合征的高危儿童，以及父母没有情绪障碍的儿童对照组的执行功能的特定组件过程的测试能力。本研究的第二个目的是检查，通过父母和教师的评级，是否有BPD的风险，并没有情绪综合征的儿童表现出损害的日常生活活动，被认为是依赖于完整的执行功能技能，并检查这些功能缺陷和执行能力的神经心理学测试的性能之间的关系。