Mechanisms of PTEN regulation by Ndfip1 and their biological consequences for neuron survival during brain injury

Ndfip1 调节 PTEN 的机制及其对脑损伤期间神经元存活的生物学影响

• 批准号: nhmrc : 1022728
• 负责人: Prof Seong-Seng Tan
• 金额: $ 45.79万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-pten-regulation-brain-injury/110214
• 关键词: Mechanisms; PTEN; regulation; Ndfip1; their

We have discovered a new protein (Ndfip1) that protects brain cells from death after brain injury from trauma and stroke. We will investigate why this protein is activated only in some, but not in other, brain cells after injury. In this application, we will study the mechanisms behind neuron protection, and use this information to explore how to increase the number of brain cells activating Ndfip1.

我们发现了一种新的蛋白质 (Ndfip1)，可以保护脑细胞免于因外伤和中风造成的脑损伤后死亡。我们将研究为什么这种蛋白质在受伤后仅在某些脑细胞中被激活，而在其他脑细胞中则不被激活。在此应用中，我们将研究神经元保护背后的机制，并利用这些信息探索如何增加激活 Ndfip1 的脑细胞数量。