A Self-Monitoring Artificial Vascular Graft

描述（由申请人提供）： 大多数人造血管移植物，其中60，000人去年在美国植入，在不到三年内失败，导致截肢。通过移植物的血流减少已被证明是筏失败的前兆。该计划的长期目标是通过使移植物“智能”来延长人工移植物的寿命，即使移植物能够测量其流量并在流量减少时呼叫医生进行干预。 该项目的第一阶段实现了其特定目标：1）使用足够小的多普勒传感器进行精确的流量测量，该传感器可以完全嵌入血管移植物中; 2）设计能够驱动传感器并将流量信息无线传输到床边监护仪的电路，同时从植入式电池消耗足够低的功率，使用寿命为5年。 第二阶段是提供数据，使人类临床试验。将对组件寿命和可靠性进行确认，并在动物体内制造和植入功能性智能移植物。动物试验将证明这些器械的安全性、功能性和延长的移植物寿命。

DESCRIPTION (provided by applicant): Most artificial vascular grafts, of which 60,000 were implanted in the USA last year, fail in less than three years, leading to amputation. Diminishing blood flow through the graft has been shown to be a precursor of raft failure. The long-term objective of this program is to extend artificial graft life by making the grafts "smart", i.e. making the graft capable of measuring its flow and calling a physician for intervention if the flow diminishes. Phase I of the program achieved its specific aims of 1) demonstrating accurate flow measurement using a Doppler sensor small enough to be completely embedded in a vascular graft and 2) designing circuitry capable of driving the sensor and wirelessly transmitting the flow information to a bedside monitor while consuming low enough power for 5-years of life from an implantable battery. Phase II is to provide data to enable human clinical trials. Component life and reliability will be validated, and functional smart grafts will be fabricated and implantated in animals. Animal trials will demonstrate the safety, functionality, and extended graft life of these devices.