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A Self-Monitoring Artificial Vascular Graft

自我监控人工血管移植物

基本信息

批准号：
6647378
负责人：
David Vilkomerson
金额：
$ 9.98万
依托单位：
DVX, LLC
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-06-01 至 2003-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6647378
关键词：
artificial membranes bioengineering /biomedical engineering biomaterial development /preparation biomaterial evaluation biomaterial interface interaction biomedical device power system biomedical equipment development blood vessel prosthesis patient monitoring device ultrasound blood flow measurement

项目摘要

DESCRIPTION (provided by applicant): Development of a self-monitoring graft is the long term goal of this project. Such a graft, rather than being a passive conduit for blood, would measure the blood flowing through it and, if the flow approached levels at which the graft might thrombose, communicate the need for treatment directly to the physician. At present, 60,000 artificial by-pass leg grafts per year are implanted in the USA. Most fail within three years,leading to amputation. By making such grafts "smart grafts" that communicate impending failure, many of these limbs should be saved. Special ultrasound transducers have been developed that can be embedded in the walls of the graft and measure the blood flow passing through the graft. The proposed Phase I work would demonstrate the feasibility of the smart graft by constructing an operating graft with flow-sensing capability, and by analysis show that the associated circuitry and power source could be implanted with 5 year or more life. The Phase II continuation of the program would undertake the fabrication and implantation of prototype smart grafts.

描述（由申请人提供）：开发一种自我监测的移植物是该项目的长期目标。这样的移植物，而不是被动的血液管道，将测量流经它的血液，如果流量接近移植物可能形成血栓的水平，将治疗的需要直接传达给医生。目前，美国每年植入60，000例人工旁路腿移植物。大多数在三年内失败，导致截肢。通过使这种移植物成为“智能移植物”，传达即将发生的失败，许多这样的肢体应该得到挽救。已经开发出特殊的超声换能器，可以嵌入移植物的壁中并测量通过移植物的血流。拟定的I期工作将通过构建具有流量传感能力的手术移植物来证明智能移植物的可行性，并通过分析表明相关电路和电源可以植入5年或更长的寿命。该计划的第二阶段继续将进行原型智能移植物的制造和植入。