A Self-Monitoring Artificial Vascular Graft

自我监控人工血管移植物

• 批准号: 6647378
• 负责人: David Vilkomerson
• 金额: $ 9.98万
• 依托单位: DVX, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647378
• 关键词: artificial membranes; bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomedical device power system; biomedical equipment development; blood vessel prosthesis; patient monitoring device; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): Development of a self-monitoring graft is the long term goal of this project. Such a graft, rather than being a passive conduit for blood, would measure the blood flowing through it and, if the flow approached levels at which the graft might thrombose, communicate the need for treatment directly to the physician. At present, 60,000 artificial by-pass leg grafts per year are implanted in the USA. Most fail within three years,leading to amputation. By making such grafts "smart grafts" that communicate impending failure, many of these limbs should be saved. Special ultrasound transducers have been developed that can be embedded in the walls of the graft and measure the blood flow passing through the graft. The proposed Phase I work would demonstrate the feasibility of the smart graft by constructing an operating graft with flow-sensing capability, and by analysis show that the associated circuitry and power source could be implanted with 5 year or more life. The Phase II continuation of the program would undertake the fabrication and implantation of prototype smart grafts.

描述（由申请人提供）：

项目成果

Accurate blood peak velocity estimation using spectral models and vector doppler.

使用频谱模型和矢量多普勒精确估计血液峰值速度。

• DOI: 10.1109/tuffc.2015.006982
• 发表时间: 2015
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Ricci,Stefano;Vilkomerson,David;Matera,Riccardo;Tortoli,Piero
• 通讯作者: Tortoli,Piero