Physiological Controller for Rotary Blood Pumps

旋转式血泵的生理控制器

• 批准号: 6803953
• 负责人: MICHAEL RICCI
• 金额: $ 37.48万
• 依托单位: LAUNCHPOINT TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803953
• 关键词: artificial intelligence; auxiliary heart prosthesis; biomedical device power system; biomedical equipment development; cardiac output; circulatory assist; computer system design /evaluation; cow; electrophysiology; hemolysis; mathematical model; microprocessor /microchip; sheep

DESCRIPTION (provided by applicant): As the prospects of chronic mechanical assistance for the failing human heart are fast becoming a reality, and patients are indeed returning home to regain a normal lifestyle, the limitations of this technology upon quality of life are becoming more apparent. To address many of these limitations, investigators are developing next-generation ventricular assist devices. Based on turbopump technology, these new devices offer smaller size, greater efficiency (hence smaller batteries), high reliability, and are more cost effective as compared to their pulsatile predecessors. For all the virtues of these new turbopumps, they bring additional challenges. Arguably the most urgent is the need for added "intelligence." These relatively ignorant devices are highly dependent on feedback-control to provide normal physiological response. The goal of the Phase- II effort proposed herein is to design a robust controller that may be incorporated into these turbodynamic pump systems for clinical use. The primary end product of this program would be a validated algorithm, in the form of firmware that will be embedded into existing rotary pump controller -- capable of maintaining optimal perfusion of the patient under a variety of hemodynamic demands and disturbances, while avoiding deleterious conditions such as ventricular suction.

描述（由申请人提供）： 随着慢性机械辅助治疗人类心脏衰竭的前景迅速成为现实，患者确实回家恢复正常的生活方式，这项技术对生活质量的限制变得越来越明显。为了解决这些局限性，研究人员正在开发下一代心室辅助装置。基于涡轮泵技术，这些新设备提供更小的尺寸，更高的效率（因此更小的电池），高可靠性，并且与其脉动前辈相比更具成本效益。尽管这些新型涡轮泵具有种种优点，但它们也带来了额外的挑战。可以说，最紧迫的是需要增加"智能"。“这些相对无知的设备高度依赖于反馈控制来提供正常的生理反应。本文提出的第二阶段努力的目标是设计一种鲁棒控制器，该鲁棒控制器可以结合到这些涡轮动力泵系统中以供临床使用。该计划的主要最终产品将是一种经过验证的算法，其形式为嵌入现有旋转泵控制器的固件-能够在各种血液动力学需求和干扰下保持患者的最佳灌注，同时避免有害条件，如心室抽吸。