MEMS Intraocular Pressure Sensor

MEMS眼压传感器

• 批准号: 7271709
• 负责人: MICHAEL RICCI
• 金额: $ 22.6万
• 依托单位: LAUNCHPOINT TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7271709
• 关键词: Address; Affect; African American; Age; Amplifiers; Analog-Digital Conversion; Animals; Anterior; Area; Awareness; Back; Bathing; Biocompatible; Biological Models; Blinded; Blindness; Blinking; Blood Glucose; Blood Pressure; Businesses; Calculi; Caring; Cataract; Cellular Phone; Code; Communication; Computer software; Computerized Medical Record; Control Groups; Cornea; Coupling; Data; Decompression Sickness; Dependence; Detection; Devices; Diagnosis; Digital Signal Processing; Discipline; Drug Delivery Systems; Eating; Economics; Elderly; Electronics; Equilibrium; Eye; Film; Frequencies; Glaucoma; Goals; Health; Hour; Human Resources; Image; Implant; Infection; Injectable; Injection of therapeutic agent; Interview; Intraocular Lens Implantation; Intraocular lens implant device; Lead; Left; Liquid substance; Literature; Los Angeles; Magnetic Resonance Imaging; Magnetism; Marketing; Masks; Measurement; Measures; Mechanics; Medical; Methods; Microscope; Minor; Monitor; Motion; National Eye Institute; Newly Diagnosed; Noise; Notification; Numbers; Object Attachment; Office Visits; Operative Surgical Procedures; Optics; Pacemakers; Patient Monitoring; Patients; Persons; Pharmaceutical Preparations; Phase; Physiologic Intraocular Pressure; Physiologic pulse; Physiological; Placement; Plants; Pliability; Procedures; Process; Pulse taking; Reading; Research Personnel; Respiratory Diaphragm; Retinal; Risk; Saline; Secure; Shapes; Signal Transduction; Silicon; Silicones; Software Design; Solutions; Source; Specialist; Structure; Supervision; Surgical sutures; Surveys; System; Technology; Testing; Thick; Time; Torque; Training; Tweens; United States Food and Drug Administration; Upper arm; Vacuum; Validation; Variant; Width; analog; aqueous; base; biomaterial compatibility; capsule; compliance behavior; computerized data processing; concept; cost; day; design; digital; dipole moment; electric impedance; implantation; implanted sensor; improved; innovation; lens; limbal; magnetic field; manufacturing process; miniaturize; pressure; response; seal; sensor; size; success; telemetering; tonometry; voltage

DESCRIPTION (provided by applicant): Glaucoma is a leading cause of vision loss, particular in the elderly. In spite of its tremendous impact on health, the diagnosis and treatment of glaucoma is hindered by the difficulty of obtaining frequent intraocular pressure measurements that can enhance treatment and encourage patient compliance. Moreover, the problem is compounded by large intraocular pressure variations within a single day. This Phase I project will design 1mm and 3mm scale microelectromechanical (MEMS) pressure sensors suitable for attachment to intraocular lenses (IOLs) and as intravitreal implants, respectively. The 3mm scale device will be fabricated and tested in Phase I to demonstrate feasibility. The pool of patients with glaucoma at the time of IOL implantation is limited to one or two hundred thousand per year, but piggy-backing on an IOL does not subject patients to additional risks of infection. The intravitreal implant is suitable for essentially all glaucoma patients with minor risks associated with a specialized surgical procedure. The measurement of intraocular pressure is critical to the diagnosis and treatment of glaucoma. However, such measurements require relatively costly and frequent office visits. This project applies new electromechanical systems (MEMS) technology to enable patients to monitor their own intraocular pressure via two possible implant methods. One is an attachment to an intraocular lens and the second is an implantation into the vitreous cavity.

描述（由申请人提供）：青光眼是视力丧失的主要原因，特别是在老年人中。尽管其对健康的巨大影响，青光眼的诊断和治疗受到难以获得频繁的眼内压测量的阻碍，所述眼内压测量可以增强治疗并鼓励患者依从性。此外，一天之内眼内压变化大，使问题更加复杂。该第一阶段项目将设计1mm和3mm规模的微机电（MEMS）压力传感器，分别适用于连接到人工晶状体（IOL）和作为玻璃体内植入物。将在第一阶段制造和测试3 mm尺寸的器械，以证明可行性。在IOL植入时患有青光眼的患者的池被限制为每年10万或20万，但是在IOL上背负不会使患者遭受额外的感染风险。玻璃体内植入物基本上适用于所有青光眼患者，与专门的外科手术相关的风险较小。眼压测量对青光眼的诊断和治疗至关重要。然而，这种测量需要相对昂贵和频繁的办公室访问。该项目应用新的机电系统（MEMS）技术，使患者能够通过两种可能的植入方法监测自己的眼内压。一种是附着到眼内透镜上，第二种是植入到玻璃体腔中。