Mechanisms regulating mitochondrial outer membrane permeabilisation during programmed cell death

程序性细胞死亡过程中线粒体外膜透化的调节机制

• 批准号: nhmrc : 1031274
• 负责人: Dr Diana Stojanovski
• 金额: $ 20.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-regulating-mitochondrial-cell-death/110795
• 关键词: Mechanisms; regulating; mitochondrial; outer; membrane

Apoptosis is a form of cell suicide that is vital in human development and health by removing damaged or unwanted cells in a regulated manner. Disturbances in this pathway are known to be the cause of cancers and other diseases. This research will investigate how the pivotal step in cell death, termed mitochondrial outer membrane permeabilisation (MOMP) is regulated.

细胞凋亡是细胞自杀的一种形式，通过以受调控的方式去除受损或不需要的细胞，对人类发育和健康至关重要。已知这一途径的紊乱是癌症和其他疾病的原因。这项研究将研究细胞死亡的关键步骤，称为线粒体外膜透化（MOMP）是如何调节的。