PDGF and Proliferative Vitreoretinopathy

PDGF和增殖性玻璃体视网膜病变

基本信息

  • 批准号:
    6708573
  • 负责人:
  • 金额:
    $ 49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-08-01 至 2009-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Our findings in the previous grant period included that platelet-derived growth factor (PDGF) receptors (PDGFRs) are present in epiretinal membranes of human proliferative vitreoretinopathy (PVR) donors, and that PDGFRs are required for development of PVR in a rabbit model of the disease. We will continue to investigate the role of PDGF in PVR as outlined in these specific aims: 1. To investigate why the alphaPDGFR is better at causing PVR than the betaPDGFR. In the rabbit model of PVR, cells expressing the alphaPDGFR induce PVR much more effectively than do the same cells expressing the betaPDGFR. We will identify the region(s) of the alphaPDGFR that enable the betaPDGFR to induce PVR by using chimeras of the alpha and betaPDGFRs. 2. Test the hypothesis that TGFbeta activates the alphaPDGFR via PDGF-CC. Activation of the PDGFR is a prerequisite for PVR in rabbits, and in this aim we will test whether our recently discovered unconventional, transforming growth factor beta (TGFbeta)-dependent route to activate the alphaPDGFR is dependent on PDGF-CC. 3. Identify factors that augment the PVR potential of retinal pigment epithelial cells (RPEs). While fibroblasts efficiently induce PVR in our rabbit model, RPE cells do not. This deficiency will be exploited to identify factors that elevate the PVR potential of RPE cells. 4. Screen epiretinal membranes from human PVR donors for expression of factors that promote PVR in the animal model. We will screen epiretinal membranes from human PVR donors for the expression of factors that are critical for PVR in the rabbit model (like alphaPDGFR, activated alphaPDGFR and ligands for this receptor). Together these studies will identify factors that promote PVR and elucidate the relationships between such factors. In addition, our finding will critically evaluate the relevance of the rabbit model to human disease. This information will guide future efforts to develop approaches to prevent and/or treat PVR in humans.
描述(由申请人提供):我们在之前拨款期的发现包括血小板衍生生长因子(PDGF)受体(PDGFRs)存在于人类增殖性玻璃体视网膜病变(PVR)供体的视网膜前膜中,并且PDGFRs是兔疾病模型中PVR发展所必需的。我们将继续研究PDGF在PVR中的作用,具体目标如下:

项目成果

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ANDRIUS KAZLAUSKAS其他文献

ANDRIUS KAZLAUSKAS的其他文献

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{{ truncateString('ANDRIUS KAZLAUSKAS', 18)}}的其他基金

Signaling events that control the fate of existing vessels
控制现有船只命运的信号事件
  • 批准号:
    7296206
  • 财政年份:
    2007
  • 资助金额:
    $ 49万
  • 项目类别:
Understanding vessel regression
了解血管回归
  • 批准号:
    7076845
  • 财政年份:
    2005
  • 资助金额:
    $ 49万
  • 项目类别:
Understanding vessel regression
了解血管回归
  • 批准号:
    6903226
  • 财政年份:
    2005
  • 资助金额:
    $ 49万
  • 项目类别:
Understanding vessel regression
了解血管回归
  • 批准号:
    7266226
  • 财政年份:
    2005
  • 资助金额:
    $ 49万
  • 项目类别:
A GENE THERAPY-BASED APPROACH TO PREVENT PVR
基于基因治疗的预防 PVR 的方法
  • 批准号:
    6641237
  • 财政年份:
    2000
  • 资助金额:
    $ 49万
  • 项目类别:
A GENE THERAPY-BASED APPROACH TO PREVENT PVR
基于基因治疗的预防 PVR 的方法
  • 批准号:
    6196190
  • 财政年份:
    2000
  • 资助金额:
    $ 49万
  • 项目类别:
A GENE THERAPY-BASED APPROACH TO PREVENT PVR
基于基因治疗的预防 PVR 的方法
  • 批准号:
    6524964
  • 财政年份:
    2000
  • 资助金额:
    $ 49万
  • 项目类别:
PDGF and Proliferative Vitreoretinopathy
PDGF和增殖性玻璃体视网膜病变
  • 批准号:
    7273521
  • 财政年份:
    2000
  • 资助金额:
    $ 49万
  • 项目类别:
PDGF and PVR
PDGF和PVR
  • 批准号:
    6927161
  • 财政年份:
    2000
  • 资助金额:
    $ 49万
  • 项目类别:
PDGF and PVR
PDGF和PVR
  • 批准号:
    7087790
  • 财政年份:
    2000
  • 资助金额:
    $ 49万
  • 项目类别:

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