Training Grant in Computational Genomics

计算基因组学培训补助金

• 批准号: 6767305
• 负责人: LYLE UNGAR
• 金额: $ 50.32万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-16 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6767305
• 关键词: Training; Grant; Computational; Genomics

DESCRIPTION (provided by applicant): This proposal is for the renewal of a grant to train graduate and post-doctoral students in computational biology. Over the last 10 years, the University of Pennsylvania has built a strong program for training students in genomics, bioinformatics and computational biology. The training program of this grant is part of a larger training program that also embraces four different undergraduate concentrations in mathematical and computational biology and a Master's program in Bioinformatics, and which occurs in the context of a strong collaborative research effort spanning the many disciplines involved in computational biology. Current problems in computational genomics, such as trying to understand regulatory mechanisms, require combining disparate sources of knowledge such as gene expression, promoter region and intron structure and function, and comparisons across multiple organisms. Such research requires deep understanding of the biology of the organism or phenomenon being studied, and of the experimental techniques and statistical and algorithmic methods available. The purpose of this grant is to train students with these skills and to produce researchers who will be able to address current and future research needs in computational biology. Penn has made tremendous progress in computational biology training in the last few years, as was hoped by the authors of the original training grant proposal. Penn now has a new Graduate Group, Genomics and Computational Biology (GCB) within the Biomedical Graduate Studies (BGS) program in the School of Medicine (SOM), into which we took 8 PhD (including one MD/PhD) students last year, and have 7 PhD students accepted for matriculation in the fall of 2003. While it is envisioned that graduate training support from this grant will be increasingly focused on students in GCB, we plan to continue.supporting PhD students and post docs in the Biology and the Computer and Information Science (CIS) departments, as well as in the School of Medicine. We have also added new courses serving these students, and hired two new faculty members in computational biology. Most Genomics activities at Penn fall under the umbrella of the Penn Genomics Institute (PGI). PGI provides a wide variety of computational and experimental resources including microarry facilities, proteomics facilities, hardware and software for bioinformatics, and training and consulting. All students funded by this grant will have access to these facilities. PGI includes the Penn Center for Bioinformatics (PCBI), which although mainly a research center, is significantly involved with the training program. For example, in their first year, GCB students are housed in PCBI, and students will do research rotations with PCBI faculty.

描述(申请人提供)：这项建议是为了更新一项资助，以培训计算生物学方面的研究生和博士后。在过去的10年里，宾夕法尼亚大学建立了一个强大的项目，为学生提供基因组学、生物信息学和计算生物学方面的培训。这笔赠款的培训计划是一个更大的培训计划的一部分，该计划还包括四个不同的数学和计算生物学本科专业和一个生物信息学硕士课程，该培训计划是在计算生物学涉及的许多学科的强大合作研究努力的背景下进行的。 目前计算基因组学中的问题，如试图理解调控机制，需要结合不同的知识来源，如基因表达、启动子区域和内含子结构和功能，以及跨多个生物体的比较。这样的研究需要深入了解正在研究的生物体或现象的生物学，以及可用的实验技术和统计和算法方法。这笔赠款的目的是培训学生掌握这些技能，并培养出能够满足当前和未来计算生物学研究需求的研究人员。 宾夕法尼亚大学在过去几年里在计算生物学培训方面取得了巨大的进步，正如最初培训拨款提案的作者所希望的那样。宾夕法尼亚大学医学院(SOM)的生物医学研究生研究(BGS)项目中现在有一个新的研究生小组，基因组学和计算生物学(GCB)，我们去年招收了8名博士生(包括1名MD/博士生)，并于2003年秋季录取了7名博士生。虽然预计这笔赠款的研究生培训支持将越来越多地集中在GCB的学生身上，但我们计划继续支持生物学、计算机和信息科学(CIS)系以及医学院的博士生和博士后。我们还为这些学生增加了新的课程，并聘请了两名计算生物学的新教员。 宾夕法尼亚大学的大多数基因组学活动都隶属于宾夕法尼亚大学基因组学研究所(PGI)。PGI提供各种计算和实验资源，包括微阵列设施、蛋白质组学设施、生物信息学硬件和软件以及培训和咨询。所有由这笔助学金资助的学生都将可以使用这些设施。PGI包括宾夕法尼亚大学生物信息学中心(PCBI)，该中心虽然主要是一个研究中心，但也参与了培训计划。例如，在第一年，GCB的学生被安置在PCBI，学生们将与PCBI的教职员工一起进行研究轮换。