MECHANISMS OF SHOCK WAVE ACTION FOR IMPROVED SWL

改善 SWL 的冲击波作用机制

• 批准号: 6891513
• 负责人: James Alexander McAteer
• 金额: $ 22.22万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891513
• 关键词: biomechanics; biomedical equipment development; biomedical equipment safety; biophysics; cellular pathology; disease /disorder proneness /risk; epithelium; injury; kidney disorder; kidney function; lithotripsy; mechanical stress; morphology; nephrolithiasis; oxidative stress; photography; physical property; renal ischemia /hypoxia; renal tubule; sound; swine; tissue /cell culture; ultrasound biological effect; vascular endothelium

Project 2: Mechanisms of Shock Wave Action for Improved SWL The goal of Project 2 is to find ways to improve lithotripsy. To reach this goal we have identified three main objectives. We will: 1) provide an objective basis for the choice of lithotripter settings for SW-rate and power used in treating kidney stones (Aims 1 and 2), 2) determine the role of cavitation bubble cluster dynamics in stone fragmentation and find ways for the urologist to enhance the positive action of cavitation in stone breakage (Aims 3 and 4), and 3) evaluate the efficacy and safety of newer generation lithotripters, including a promising dual pulse lithotripter (Aims 5 and 6). Project 2 experiments will be highly interactive with the other projects of this Program Project Grant. In collaboration with Projects 3 and 4 we will utilize high-speed photography, dual passive cavitation detection and B-scan ultrasound to determine the mechanism responsible for improved stone breakage at slow SW-rate, and will find the balance between SW-rate and power that gives improved stone comminution. In studies with Project 1 we will use a new animal model for stone implantation in the pig kidney and the ureter to help evaluate the effect of lithotfipter settings on stone breakage. With our colleagues in Projects 3 and 4 we will analyze cavitation bubble activity in vitro, to determine how the environment of a stone--that is, its tissue boundaries and the composition of the fluid that bathes the stoneminfluence cavitation bubble dynamics involved in stone fragmentation. Using our in vivo stone implantation model and our Project 1 animal model of renal injury in SWL, and in collaboration with projects 3 and 4, we will evaluate and compare the efficacy and safety of different types of lithotripters -- including the electrohydraulic Dornier HM3, the electromagnetic Dornier Compact Delta (a newer generation tight-focal-zone, high power machine), and the Direx Duet dual-pulse lithotripter. Thus, project 2 will find ways to improve how lithotripsy is performed using conventional lithotripters, evaluate newer machines so that we can learn to use them more safely and effectively, and test a promising new concept for dual pulse SW delivery that has the potential to improve SWL.

项目2：改进SWL的冲击波作用机理 项目2的目标是找到改进碎石术的方法。为了实现这一目标，我们确定了三个主要目标。我们将：1)为选择治疗肾结石所用的短波速率和功率的碎石机设置提供客观依据(AIMS 1和2)；2)确定空化泡团动力学在结石粉碎中的作用，并为泌尿科医生寻找增强空化在碎石中的积极作用的方法(AIMS 3和4)；以及3)评估新一代碎石机的有效性和安全性，包括前景看好的双脉冲碎石机(AIMS 5和6)。 项目2实验将与本项目资助的其他项目高度互动。在与项目3和项目4的合作中，我们将利用高速摄影、双被动空化检测和B超来确定在慢波速下改进的石材破碎的机制，并将在波速和功率之间找到平衡，从而提供改进的石材粉碎。在项目1的研究中，我们将使用一种新的动物模型在猪肾和输尿管内植入结石，以帮助评估碎石器设置对结石粉碎的影响。与我们在项目3和4中的同事一起，我们将在体外分析空泡的活动，以确定石头的环境--即其组织边界--如何 而洗涤石块的流体的组成会影响石块破碎过程中的空化气泡动力学。使用我们的活体结石植入模型和我们的项目1肾损伤动物模型，并与项目3和项目4合作，我们将评估和比较不同类型的碎石机的疗效和安全性，包括电液压式Dornier HM3、电磁Dornier紧凑型Delta(新一代紧焦区高功率碎石机)和DiREx Duet双脉冲碎石机。 因此，项目2将找到改进使用传统碎石机进行碎石术的方法，评估较新的机器，以便我们能够学习更安全和有效地使用它们，并测试具有改善SWL潜力的双脉冲短波传输的有前景的新概念。