Animal Core

动物核心

• 批准号: 6990240
• 负责人: DAVID A CHERESH
• 金额: $ 6.1万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-12 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6990240
• 关键词: SCID mouse; angiogenesis inhibitors; animal colony; antineoplastics; athymic mouse; cell line; combinatorial chemistry; drug discovery /isolation; drug screening /evaluation; metastasis; neoplastic growth; small molecule

The Animal Core will be directed by Dr. David Cheresh. The major function of this core will be to examine the anti-tumor activity of compounds developed in mice bearing human tumors. Compounds developed in the Vogt, Boger and Cheresh laboratory will target human tumor growth by targeting the oncogene function within tumor cells, while compounds developed as integrin antagonists will be used to block tumor-induced angiogenesis. This core will also be used to assess the role of targeted gene delivery on angiogenesis, tumor growth and metastasis. The effect of blocking angiogenesis will be further analyzed in terms of anti-tumor activity in two mouse models: 1) the nude mouse model, and 2) the SCID mouse human skin chimeric model as well as syngeneic models.

动物核心将由David Cheresh博士执导。该核心的主要功能是 检查在携带人类肿瘤的小鼠中发育的化合物的抗肿瘤活性。在VOGT，Boger和Cheresh实验室中开发的化合物将通过靶向肿瘤细胞中的癌基因功能来靶向人类肿瘤的生长，而作为整联蛋白拮抗剂开发的化合物将用于阻断肿瘤诱导的血管生成。该核心还将用于评估靶向基因递送对血管生成，肿瘤生长和转移的作用。在两种小鼠模型中，将根据抗肿瘤活性进一步分析阻塞血管生成的效果：1）裸小鼠模型，以及2）SCID小鼠人类皮肤嵌合模型以及同步模型。