Improved Polymeric Restoratives Through Molecular Design

通过分子设计改进聚合物修复剂

• 批准号: 6794156
• 负责人: J DAVID EICK
• 金额: $ 117.18万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794156
• 关键词: biomaterial development /preparation; biomaterial evaluation; composite resins; dental materials

PROGRAM PROJECT DESCRIPTION (provided by applicant): Previous research has produced an oxirane/polyol dental composite system that will be available for clinical testing by 03/02. The overall goal of this project is to apply an integrated approach involving innovative computer modeling and organic synthesis, novel biocompatibility evaluation, comprehensive materials characterization, and mechanistic development of improved dental composites. Our intent is "to improve the low stress/low shrinkage adhesive oxiranel/polyol composite system so that a restorative material will be produced that will be significantly better than methyacrylate based composite systems and be a suitable replacement for dental amalgam." The specific aims for the overall project are: 1) to focus our research efforts on understanding the underlining scientific principles governing the behavior of oxirane/polyol based composite systems; 2) through two cores to provide administrative, statistical, and budgetary support for the investigators, consultants, and program directors and to provide biocompatibility testing for the new materials; 3) through four R01 subprojects to employ computer modeling to develop low stress/low shrinkage resin matrix materials and adhesives, to study genetic and biomimetics responses of the new materials, and to improve to composite system; and 4) to continue to provide a stimulating research environment for the scientists and graduate students involved in this program. The improvement of advanced dental composites systems is greatly promoted when multi-disciplinary teams of scientists come together with their talent, laboratory resources, and equipment. Indeed, the purpose of this grant is to provide the synergistic focus for the team of scientists to improve the low stress/low shrinkage adhesive oxirane/polyol based composite system and to understand more fully the underlining scientific principals governing the behavior of theses materials. The cooperative efforts among the University of Missouri at Kansas City researchers, investigators at the Midwest Research Institute in Kansas City and researchers at the 3M Company has been most productive and have established the necessary cadre of scientists who can accomplish this overall objective. If we are successful, we will gain a deeper understanding of the behavior of low stress/low shrinkage oxirane/polyol based composite systems. Also, dental care for the general public will be substantially improved and a suitable replacement for dental amalgam will be available.

计划项目描述(由申请人提供)：以前的研究 已经生产了一种环氧乙烷/多元醇牙科复合系统，将可供使用 在03/02年前进行临床测试。此项目的总体目标是应用 创新的计算机建模和有机结合的综合方法 合成、新型生物相容性评价、综合材料 改进的牙科复合材料的表征和机理发展。 我们的目标是“改善低应力/低收缩粘合剂氧烷/多元醇” 复合系统，这样将产生修复材料，将 明显优于甲基丙烯酸酯基复合体系，并成为 适用于牙科银汞合金的替代物。 项目是：1)将我们的研究重点放在理解划线上 环氧乙烷/多元醇基复合材料行为的科学原理 系统；2)通过两个核心提供管理、统计和 为调查人员、顾问和项目主任提供预算支持 为新材料提供生物兼容性测试；3)至四个R01 利用计算机建模开发低应力/低收缩的子项目 树脂基质材料和粘合剂，用于研究遗传学和仿生学 新材料的响应，并对复合体系进行改进；4) 继续为科学家提供激励的研究环境和 参与该项目的研究生。高级牙科的改进 当多学科团队合作时，复合材料系统将得到极大的推动 科学家带着他们的才华、实验室资源和 设备。事实上，这笔赠款的目的是提供协同效应 专注于科学家团队，以提高低应力/低收缩 胶粘剂环氧乙烷/多元醇复合体系，并更全面地了解 强调管理这些材料行为的科学原理。 密苏里大学堪萨斯城分校的合作努力 堪萨斯城中西部研究所的研究人员和研究人员 3M公司的研究人员效率最高，并建立了 能够实现这一总体目标的必要的科学家干部。如果我们 都是成功的，我们将对Low的行为有更深刻的了解 应力/低收缩环氧烷/多元醇基复合材料体系。还有，牙科护理 对于广大市民来说，将会有实质性的改善和适当的 将提供牙科汞合金的替代品。