Improved Polymeric Restoratives Through Molecular Design

通过分子设计改进聚合物修复体

• 批准号: 6424412
• 负责人: J DAVID EICK
• 金额: $ 106.68万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2006-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6424412
• 关键词: biomaterial development /preparation; biomaterial evaluation; composite resins; dental materials

PROGRAM PROJECT DESCRIPTION (provided by applicant): Previous research has produced an oxirane/polyol dental composite system that will be available for clinical testing by 03/02. The overall goal of this project is to apply an integrated approach involving innovative computer modeling and organic synthesis, novel biocompatibility evaluation, comprehensive materials characterization, and mechanistic development of improved dental composites. Our intent is "to improve the low stress/low shrinkage adhesive oxiranel/polyol composite system so that a restorative material will be produced that will be significantly better than methyacrylate based composite systems and be a suitable replacement for dental amalgam." The specific aims for the overall project are: 1) to focus our research efforts on understanding the underlining scientific principles governing the behavior of oxirane/polyol based composite systems; 2) through two cores to provide administrative, statistical, and budgetary support for the investigators, consultants, and program directors and to provide biocompatibility testing for the new materials; 3) through four R01 subprojects to employ computer modeling to develop low stress/low shrinkage resin matrix materials and adhesives, to study genetic and biomimetics responses of the new materials, and to improve to composite system; and 4) to continue to provide a stimulating research environment for the scientists and graduate students involved in this program. The improvement of advanced dental composites systems is greatly promoted when multi-disciplinary teams of scientists come together with their talent, laboratory resources, and equipment. Indeed, the purpose of this grant is to provide the synergistic focus for the team of scientists to improve the low stress/low shrinkage adhesive oxirane/polyol based composite system and to understand more fully the underlining scientific principals governing the behavior of theses materials. The cooperative efforts among the University of Missouri at Kansas City researchers, investigators at the Midwest Research Institute in Kansas City and researchers at the 3M Company has been most productive and have established the necessary cadre of scientists who can accomplish this overall objective. If we are successful, we will gain a deeper understanding of the behavior of low stress/low shrinkage oxirane/polyol based composite systems. Also, dental care for the general public will be substantially improved and a suitable replacement for dental amalgam will be available.

项目描述（由申请人提供）：以前的研究 已经生产了一种环氧乙烷/多元醇牙科复合材料系统， 03/02进行临床试验该项目的总体目标是应用 综合方法，包括创新的计算机建模和有机 合成，新型生物相容性评价，综合材料 表征和改进的牙科复合材料的机械开发。 我们的目的是“改进环氧乙烷/多元醇的低应力/低收缩粘合剂 复合系统，以便将生产的修复材料， 明显优于基于甲基丙烯酸酯的复合体系， 适合替代牙科汞合金。“总体目标的具体目标 项目是：1）将我们的研究工作集中在理解 环氧乙烷/多元醇基复合材料性能的科学原理 系统; 2）通过两个核心提供行政、统计和 为调查人员、顾问和项目主管提供预算支持， 为新材料提供生物相容性试验; 3）通过4个R 01 利用计算机建模开发低应力/低收缩的子项目 树脂基质材料和粘合剂，研究遗传和仿生学 新材料的响应，并改进复合系统;和4） 继续为科学家提供一个激励的研究环境， 参与这个项目的研究生。高级牙科的改进 复合材料系统是大大促进时，多学科的团队， 科学家们聚集在一起，他们的才华，实验室资源， 设备.事实上，这笔赠款的目的是提供协同作用， 科学家团队专注于改善低应力/低收缩 粘合剂环氧乙烷/多元醇基复合体系，并更充分地了解 强调管理这些材料行为的科学原则。 位于堪萨斯城的密苏里州大学之间的合作努力 位于堪萨斯城的中西部研究所的研究人员和 3 M公司的研究人员一直是最富有成效的，并建立了 有必要的科学家干部谁可以完成这一总体目标。如果我们 成功的话，我们将更深入地了解低收入者的行为。 应力/低收缩环氧乙烷/多元醇基复合材料体系。此外，牙科护理 为市民提供的服务将会大大改善， 牙科汞合金的替代品将可提供。