Mechanisms and treatment of upper airway collapse in obstructive sleep apnoea

阻塞性睡眠呼吸暂停上气道塌陷的机制及治疗

• 批准号: nhmrc : 109903
• 负责人: Prof Peter Eastwood
• 金额: $ 21.92万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-treatment-upper-sleep-apnoea/81436
• 关键词: Mechanisms; treatment; upper; airway; collapse

Obstructive sleep apnoea (OSA) is characterized by intermittent closure of the upper airway (throat) resulting in episodes of decreased blood oxygen levels, increased blood pressure and disturbed sleep. Repetitive overnight arousals from sleep cause excessive daytime tiredness and lethargy, which have major consequences for social well-being and productivity in our community. OSA is a common condition, affecting as many as 2 to 4% of middle aged adults, and is associated with an increased cardiovascular risk, however the mechanisms underlying the increased upper airway collapsibility in individuals with OSA are not well understood. The proposed studies represent a series of investigations into fundamental mechanisms of neural and mechanical control of upper airway patency, how these mechanisms act to stabilize the upper airway, and whether these reflex control mechanisms can be manipulated to provide a novel treatment for OSA.

阻塞性睡眠呼吸暂停（OSA）的特点是上呼吸道（喉咙）间歇性关闭，导致血氧水平降低、血压升高和睡眠紊乱。夜间反复从睡眠中醒来会导致白天过度疲劳和昏昏欲睡，这对我们社区的社会福祉和生产力产生重大影响。阻塞性睡眠呼吸暂停是一种常见疾病，影响多达2%至4%的中年人，并与心血管风险增加有关，然而，阻塞性睡眠呼吸暂停患者上呼吸道塌陷性增加的机制尚不清楚。所提出的研究代表了一系列关于上呼吸道开放的神经和机械控制的基本机制，这些机制如何稳定上呼吸道，以及是否可以操纵这些反射控制机制为OSA提供新的治疗方法的研究。