Stimulus-Evoked Vestibular Evaluation System

Vesticon将开发刺激诱发前庭评估系统（SEVE），用于检测和分析导致头晕或不平衡的条件的声音/压力诱发表现（Tullio/Hennebert现象），以应用于医疗设施。此类病症在导致头晕/失衡投诉的所有疾病中占很大比例。总的来说，头晕和不平衡障碍长期影响着620万美国人，其中与平衡有关的福尔斯占老年人意外死亡的一半以上。虽然大多数这些病症的治疗是可用的，但由于不同的原因和症状，诊断造成了显著的分类问题，需要先进的技术来帮助诊断。 检测和分析目前用于分析刺激诱发现象的技术仅限于单功能、难以操作、非解释性产品，既不全面也不省时。SEVE将自动化Tullio和Hennebert现象的诊断和定位测试，这些现象在文献中是众所周知的，但由于实用性以及缺乏标准化和培训，经常被忽视，执行不正确或根本不执行。声音和压力刺激的呈现组件，以及眼震反应的矢量分析和头部/身体姿势反应的量化组件，将与解释性和临床决策支持软件相结合并自动化。 在第一阶段，我们将：（a）调整一个头戴式装置，其中包括空间定向和运动传感器、带有红外摄像机的护目镜和一个身体佩戴式无线受试者控制台，用于传输刺激和反应数据;（B）开发一个计算机控制的耳朵刺激系统，具有声音和气压刺激;（c）开发用于解释刺激-反应数据的软件，以确定和显示眩晕的量化证据;（d）对SEVE系统进行台架测试，（e）证明SEVE在一个小型眩晕受试者队列中的价值，并评估用户友好性。对于第二阶段，我们预计工程修改，增强诊断协议的软件，解释，决策支持的综合分析，并在PI诊所和2 独立的beta网站

Vesticon will develop a Stimulus-Evoked Vestibular Evaluation System (SEVE) for detecting and analyzing sound/pressure-evoked manifestations (Tullio/Hennebert phenomena) of conditions causing dizziness or imbalance for application at medical facilities. Such conditions comprise a significant proportion of all disorders resulting in complaints of dizziness/imbalance. In all, dizziness and imbalance disorders chronically affect 6.2 million Americans, where balance-related falls account for more than half of accidental deaths in the elderly. Although treatment for most of these conditions is available, diagnosis poses a significant sorting problem due to diverse causes and symptoms, requiring advanced technology to assist in the detection and analysis. Current technology for analysis of stimulus-evoked phenomena is limited to single-function, difficult-to-operate, non-interpretative products, which are neither comprehensive nor time-efficient. SEVE will automate diagnostic and localizing tests for the Tullio and Hennebert phenomena that are well known in the literature, but are often discounted, performed incorrectly or not at all due to practicality, and a lack of standardization and training. Components for presentation of sound and pressure stimuli, and components for vector analysis of the nystagmus response and quantification of head/body postural responses, will be combined and automated with interpretative and clinical decision support software. During Phase I we will: (a) adapt a head-worn apparatus containing spatial orientation and motion sensors, goggles with infrared cameras and a body-worn wireless subject-console for transmission of stimuli and response data; (b) develop a computer-controlled ear stimulus system with sound and air pressure stimuli; (c) develop software for interpreting stimulus-response data to determine and display quantified evidence of vertigo; (d) bench-test the SEVE system and (e) demonstrate the value of SEVE in a small subject cohort with vertigo, and assess user friendliness. For Phase II, we anticipate engineering modifications, enhancing software for diagnostic protocols, interpretation, integrative analysis for decision support, and demonstrating improved applications with a large subject population at the Pl's clinic and 2 independent beta sites.