Scintillation Luminescence System for In-Vivo Dosimetry

用于体内剂量测定的闪烁发光系统

• 批准号: 6789801
• 负责人: WEI CHEN
• 金额: $ 19.52万
• 依托单位: NOMADICS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-23 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6789801
• 关键词: bioimaging /biomedical imaging; biomaterial compatibility; biomaterial development /preparation; laboratory mouse; luminescence; nanomedicine; nanotechnology; radiation dosage; scintillation spectrometry

DESCRIPTION (provided by applicant): Nomadics proposes the development of scintillation nanocomposite materials that are capable of producing scintillation luminescence (SL) and the demonstration of their applicability for in vivo dosimetry and radiation dose imaging. Successful production of SL with such materials would suggest that this technology could be used to create a new type of radiation detection for use in dosimetry, radiation therapy dose-control, and X-ray and other energy source imaging techniques. Nanoparticle-based scintillation luminescence systems would provide enhanced sensitivity for in vivo dosimetry. In Phase I, we will focus on making scintillation nanoparticles that can be used for in vivo dosimetry in support of safer, more accurate radiation cancer therapy. Nomadics will do the chemistry and optical development tasks, while Dr. Angelo Russo of NIH will conduct tests to verify the biocompatibility of the approach. Additionally, Dr. Carey Pope of Oklahoma State University, a leading toxicologist, will conduct toxicology studies to verify the suitability of SL nanoparticles for in vivo dosimetry. Once the concept is successfully demonstrated, it will be a great improvement for dose control in radiotherapy and will greatly benefit cancer patients by offering protection to adjacent healthy tissues. Additionally, with regard to the extensive use of X-ray and similar technologies in the medical industry, manufacturing, security field, inspection and non-destructive testing processes, and other applications, the proposed use of quantum materials holds the potential for higher resolution imaging at lower energy levels, resulting in substantial reductions in cost, complexity, hazards, and other negative aspects of the use of these processes.

描述(由申请人提供)： Nomadics建议开发能够产生闪烁发光(SL)的闪烁纳米复合材料，并展示其在活体剂量测量和辐射剂量成像中的适用性。用这种材料成功生产SL表明，这项技术可以用来创造一种新型的辐射探测，用于剂量测定、放射治疗剂量控制、X射线和其他能源成像技术。基于纳米粒子的闪烁发光系统将为活体剂量测量提供更高的灵敏度。在第一阶段，我们将专注于制造可用于体内剂量测定的闪烁纳米颗粒，以支持更安全、更准确的放射癌症治疗。Nomadics将负责化学和光学开发任务，而NIH的Angelo Russo博士将进行测试，以验证该方法的生物兼容性。此外，俄克拉荷马州立大学的领先毒理学家凯里·波普博士将进行毒理学研究，以验证SL纳米颗粒是否适合体内剂量测定。一旦这一概念被成功证明，它将是放射治疗中剂量控制的一大进步，并将通过保护邻近的健康组织而极大地造福癌症患者。此外，考虑到X射线和类似技术在医疗行业、制造、安全领域、检查和无损检测过程以及其他应用中的广泛使用，拟议中的使用量子材料具有在较低能级下进行更高分辨率成像的潜力，从而大幅降低使用这些过程的成本、复杂性、危险和其他负面方面。