N-HA Coated Dental Implant for Accelerated Early Healing

N-HA 涂层种植牙可加速早期愈合

• 批准号: 6787502
• 负责人: ZONGTAO ZHANG
• 金额: $ 10万
• 依托单位: INFRAMAT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6787502
• 关键词: biomaterial development /preparation; biomaterial interface interaction; blood coagulation; bone regeneration; dental implants; electrodes; hydroxyapatites; medical implant science; restorative dentistry; surface coating; titanium; wound healing

DESCRIPTION: This SBIR Phase I program is Aimed at demonstrating the feasibility of nano-hydroxyapatite ("n-HA") coated titanium Dental implants, using a novel electrophoretic deposition ("EPD") process. The HA nanocoating with approximately 50nm grain size and microsized porosities will provide higher surface bioactivity and blood coagulation compared to conventional microsized HA coatings without micropores on the surface leading to a significantly faster early-stage bone healing process. The EPD will be used to uniformly coat n-HA into the pores of Ti beaded implants, which the conventional thermal spray process cannot do. This program builds on the previous experience of Inframat in EPD fabricated HA nano-coatings for hip replacement applications in an NIH funded SBIR program and other development projects with corporate partners, demonstrating HA nano-coatings on a non-porous Ti6AI4V substrate having the unique n-HA plus micropores surface texture, 3X increased HA coating to Ti substrate adhesion strength, and 300X enhanced corrosion resistance in-vitro. The proposed program will: 1) optimize n-HA graded composition and EPD parameters, 2) coat n-HA on porous Ti beaded and screw shaped Dental implants, and 3) perform HA nanocoating property evaluations. The developed Dental implant products are expected to outperform the current anodized porous (Ti beaded) and plasma spray HA coated screw Dental implants with the benefits of accelerated early-stage healing and decreased pain for patients.

描述：该SBIR I期计划旨在使用新型的电泳沉积（“ EPD”）过程来证明纳米羟基磷灰石（“ N-HA”）涂层钛牙齿植入物的可行性。与传统的微型HA涂层相比，具有大约50nm晶粒尺寸和微质量孔隙率的HA纳米含量将提供更高的表面生物活性和血液凝结，而在表面上没有微孔的涂层，导致早期骨骼愈合过程明显更快。 EPD将用于将N-HA均匀地涂成Ti串珠植入物的毛孔，而常规的热喷雾过程无法做到这一点。 This program builds on the previous experience of Inframat in EPD fabricated HA nano-coatings for hip replacement applications in an NIH funded SBIR program and other development projects with corporate partners, demonstrating HA nano-coatings on a non-porous Ti6AI4V substrate having the unique n-HA plus micropores surface texture, 3X increased HA coating to Ti substrate adhesion strength, and 300X enhanced corrosion阻力室内。拟议的程序将：1）优化N-HA分级组合物和EPD参数，2）在多孔Ti串珠和螺钉形牙齿植入物上涂上N-HA，以及3）进行HA纳米含量评估。预计开发的牙科植入物产品将胜过当前的阳极氧化多孔（TI串珠）和等离子体喷雾HA涂层螺钉牙齿植入物，其良好的早期愈合和减轻患者的疼痛的好处。