Electrophoretic Nano-HA Coating for Improved Adhesion

描述（由申请人提供）：这个拟议的II期项目预计将生产具有显着延长寿命的羟基磷灰石（“HA”）涂层骨植入物的原型，使用室温电泳沉积工艺制造。新型透明质酸纳米涂层在体外模拟体液中具有显著提高的粘附强度和耐腐蚀性，已经在I期工作中得到证实。拟议的第二阶段计划强调开发原型植入设备，以迅速将第一阶段的纳米技术商业化。特殊涂层对基材结合强度的好处使透明质酸纳米涂层市场扩展到臀部，膝盖和牙科应用。电泳沉积的透明质酸纳米涂层在透明质酸基板界面上实现100%的结晶度和密度，确保在植入物使用期间不会降解。功能分级的透明质酸纳米涂层可以在透明质酸组织界面生成，从而促进最佳的生物活性。第二阶段的具体目标包括将实验HA浴纳米涂层组合物扩大到原型医疗植入物的中试规模生产；透明质酸纳米粒子涂层在原型医疗植入物（如髋关节、膝关节和牙科植入物）上的演示；并通过动物模型证明了涂层原型装置在体内延长使用寿命的优越性能。第二阶段的参与者包括Spire公司和德克萨斯大学圣安东尼奥分校。

DESCRIPTION (provided by applicant): This proposed phase II program is expected to produce prototype hydroxyapatite ("HA") coated bone implants with significantly extended lifetime, fabricated using a room temperature electrophoretic deposition process. Novel HA nanocoatings with significantly increased adhesion strength and corrosion resistance under simulated body fluid in-vitro have been demonstrated in the Phase I work. The proposed Phase II program emphasizes developing prototype implant devices to rapidly commercialize this Phase I nanotechnology. The benefits of exceptional coating to substrate bond strength enable expansion of the HA nanocoatings market to hips, knees, and dental applications. Achieving 100% crystallinity and density at the HA substrate interface with electrophoretic deposited HA nanocoatings assures no degradation during implant service. Functionally graded HA nanocoatings can be generated at the HA tissue interface, thus promoting optimal bioactivity. The Phase II specific aims include scale up of the experimental HA bath nanocoating composition to pilot-scale production of prototype medical implants; demonstration of the HA nanoparticles coating on prototype medical implants, such as hip, knee, and dental implants; and demonstration of superior performance of the coated prototype devices with extended lifetime in-vivo, using an animal model. Phase II participants include Spire Corporation and the University of Texas at San Antonio.