Cognitive changes in pediatric brain tumor survivors

儿童脑肿瘤幸存者的认知变化

• 批准号: 6791523
• 负责人: LLOYD A TAYLOR
• 金额: $ 4.3万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6791523
• 关键词: adolescence (12-20); attention; behavior test; brain neoplasms; chemotherapy; child psychology; clinical research; clinical trials; cognition disorders; disease /disorder proneness /risk; human subject; human therapy evaluation; long term survivor; longitudinal human study; mental disorder chemotherapy; methylphenidate; middle childhood (6-11); neoplasm /cancer surgery; neuropsychology; neurosurgery; patient oriented research; pediatric neoplasm /cancer; postdoctoral investigator; postoperative complications; psychological concentration; questionnaires; short term memory

DESCRIPTION (provided by applicant): Pediatric brain tumors comprise approximately 20 percent of all pediatric cancer diagnoses. Treatment is aggressive, involving surgery and/or irradiation/chemotherapy. Numerous studies have documented the deleterious effects of irradiation therapy and chemotherapy on neuropsychological functioning (Brown, Mulhern, & Simonian, 2002; Mulhern, et al., 1999) and findings have demonstrated declines in performance measures of intelligence, attention, and memory. Recent investigations revealed similar cognitive declines among children who undergo surgical intervention alone (Meyer et al., 2000). There have been burgeoning efforts to manage the cognitive late effects associated with the CNS treatment of pediatric cancer among those children who have received irradiation and/or chemotherapy as part of their treatment. Efforts to enhance the cognitive difficulties experienced in children with brain tumors who undergo surgical intervention alone have not routinely occurred. Because these children also evidence declines in cognitive functioning, attention, and memory, research that addresses the management of this population is critical. This application outlines a training program designed to prepare me in research design and methodology related to the implementation of randomized clinical trials aimed at identifying evidence-based treatments to address cognitive difficulties for this subset of children.

描述（由申请人提供）：小儿脑肿瘤约占所有儿科癌症诊断的20％。治疗是侵略性的，涉及手术和/或辐照/化学疗法。许多研究记录了辐射疗法和化学疗法对神经心理学功能的有害影响（Brown，Mulhern和Simonian，2002; Mulhern等，1999），发现的结果表明，智力，注意力和记忆的表现量度下降。最近的调查显示，仅接受手术干预的儿童的认知能力下降（Meyer等，2000）。在接受辐照和/或化学疗法的儿童中，与中枢神经系统治疗小儿治疗相关的认知后期作用一直在进行，作为治疗的一部分。尚未常规地发生在仅接受手术干预的脑肿瘤儿童中遇到的认知困难的努力。由于这些孩子还证明了认知功能，注意力和记忆的下降，因此解决该人群管理的研究至关重要。该应用程序概述了一项培训计划，旨在使我在研究设计和方法中做好与实施随机临床试验有关的方法，旨在识别基于证据的治疗方法，以解决这一子集的认知困难。