MR Spectroscopy of Amyotrophic Lateral Sclerosis

肌萎缩侧索硬化症的磁共振波谱检查

• 批准号: 6777005
• 负责人: LANA G KAISER
• 金额: $ 4.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6777005
• 关键词: amyotrophic lateral sclerosis; bioimaging /biomedical imaging; biomarker; brain imaging /visualization /scanning; clinical research; diagnosis design /evaluation; early diagnosis; glutamates; human subject; motor cortex; nervous system disorder diagnosis; neurons; neurotransmitter metabolism; nuclear magnetic resonance spectroscopy; pathologic process; pyramidal tracts

DESCRIPTION (provided by applicant): The overall long term goal of this project is to establish whether in vivo measurement of neuronal dysfunction in the human brain with proton Magnetic Resonance Spectroscopy (1H MRS) could assist in confirming the clinical diagnosis of ALS, especially in the early stages of the disease. In addition, proton spectroscopy may contribute to an understanding of ALS pathogenesis, because metabolites implicated in the disease process can be detected (i.e. glutamate). The following metabolites will be monitored using short echo time 1H MRS in patients with ALS and healthy controls: glutamate (GLU), an amino acid that functions as a neurotransmitter, and N-acetyl aspartate (NAA), a marker to neurons. In the previous studies of ALS via MRS (one report on increase Glu, several reports on decrease of NAA), the major technical limitation was the spectral overlap between NAA and Glu region at low field. This proposed project would use higher magnetic fields (e.g. 4T) and spectral editing techniques that will facilitate spectral interpretation of metabolites, especially Glu. The hypothesis that Glu is elevated in motor cortex region of the brain in ALS patients will be tested and the possibility of using Glu elevation as a surrogate marker of ALS will be investigated.

描述（由申请人提供）：该项目的整体长期目标 是确定在体内测量神经元功能障碍是否在 具有质子磁共振光谱（1H MRS）的人脑可以有助于 在确认ALS的临床诊断时，尤其是在 疾病。此外，质子光谱法可能有助于 对ALS发病机理的理解，因为代谢物与 可以检测到疾病过程（即谷氨酸）。以下代谢产物 将使用ALS患者和健康的患者使用短回波时间1H MRS监测 对照：谷氨酸（GLU），一种充当神经递质的氨基酸， 和N-乙酰基天冬氨酸（NAA），神经元的标记。在先前的研究中 ALS通过MRS（一份有关GLU增加的报告，关于NAA减少的几份报告）， 主要技术限制是NAA和GLU之间的光谱重叠 低场的区域。这个建议的项目将使用较高的磁场 （例如4T）和光谱编辑技术，可以促进光谱 代谢物，尤其是GLU的解释。 Glu是 ALS患者的大脑运动皮层区域升高将测试，并且 将GLU高程作为ALS的替代标记的可能性将是 调查。