Mechanisms underlying growth, lineage commitment and differentiation of liver progenitor cells

肝祖细胞生长、谱系定型和分化的潜在机制

• 批准号: nhmrc : 513896
• 负责人: Dr Belinda Knight
• 金额: $ 35.7万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-underlying-growth-progenitor-cells/77897
• 关键词: Mechanisms; underlying; growth; lineage; commitment

Liver disease is a serious health problem. Viral hepatitis, obesity and alcohol can result in end-stage liver disease. Organ transplant is the only treatment available. A widening gap between organ donations and recipients mandates alternative treatments are developed. Cell transplantation and artificial liver devices are alternatives which can use liver progenitor cells. We will investigate how factors grow and convert them into liver cells for treating liver disease patients.

肝病是一个严重的健康问题。病毒性肝炎、肥胖和酒精可导致终末期肝病。器官移植是唯一可行的治疗方法。器官捐赠和接受者之间的差距越来越大，要求开发替代治疗方法。细胞移植和人工肝装置是可以使用肝祖细胞的替代方案。我们将研究因子如何生长并将其转化为肝细胞以治疗肝病患者。