Mechanisms underlying increased cardiac and renal noradrenaline spillover during heart failure

心力衰竭期间心脏和肾脏去甲肾上腺素溢出增加的机制

• 批准号: nhmrc : 1020783
• 负责人: Dr Rohit Ramchandra
• 金额: $ 32.85万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-underlying-increased-heart-failure/110067
• 关键词: Mechanisms; underlying; increased; cardiac; renal

Heart failure is associated with increased release of the neurotransmitter noradrenaline from sympathetic nerves to the heart and the kidney. The raised levels of this neurotransmitter in the heart and the kidney are harmful and lead to reduced survival in heart failure patients. This project will increase our understanding of the mechanisms that control noradrenaline release and may lead to better treatment paradigms to target the detrimental increase in release in heart failure.

心力衰竭与交感神经向心脏和肾脏释放的神经递质去甲肾上腺素增加有关。心脏和肾脏中这种神经递质水平的升高是有害的，并导致心力衰竭患者的存活率降低。这个项目将增加我们对控制去甲肾上腺素释放的机制的理解，并可能导致更好的治疗范例，以针对心力衰竭中有害的释放增加。