Role of the Area Postrema in Determining the Increased Cardiac Sympathetic Nerve Activity in Heart Failure

后区在确定心力衰竭心脏交感神经活动增加中的作用

• 批准号: nhmrc : 1050268
• 负责人: Dr Rohit Ramchandra
• 金额: $ 32.67万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-area-postrema-heart-failure/112147
• 关键词: Role; Area; Postrema; Determining; Increased

In heart failure there is a large increase in sympathetic nerve activity to the heart that has detrimental effects on the heart and can induce sudden death. The areas in the brain causing the increased nerve activity are unknown. We will investigate the role of the area postrema, which is a window to the brain for hormones in the blood. We have evidence that this brain site maintains the high level of nerve activity in heart failure, possibly stimulated by hormones circulating in the blood.

在心力衰竭中，心脏的交感神经活动大量增加，这对心脏有不利影响，并可诱发猝死。大脑中导致神经活动增加的区域尚不清楚。我们将研究最后区的作用，它是血液中激素进入大脑的窗口。我们有证据表明，这个大脑部位在心力衰竭时保持着高水平的神经活动，可能是受到血液中循环的激素的刺激。