Community Based Clinical Trials Education Program

加州大学圣地亚哥分校癌症中心是加州大学圣地亚哥分校的一个组织研究单位。它由来自15个大学院系的120多名学术任命成员组成，另外还有来自该地区其他学术和研究机构的几名成员。其使命是降低癌症的发病率、发病率和死亡率。自1979年4月1日以来，癌症中心作为NCI指定的癌症中心获得了持续的资助，并以优秀的基础、转化、行为和临床研究为导向。在全国范围内，低临床试验应计率被认为是实现癌症预防、诊断和治疗所需的快速进展的主要障碍。在临床试验中积累具有代表性的妇女和少数群体成员的样本更加困难，限制了这些研究结果的广泛适用性。在过去的五年里，加州大学圣地亚哥分校癌症中心已经开发并试点了一个区域范围内基础设施的各种组成部分，旨在减少肿瘤学家进行临床试验转诊的障碍，并向社区肿瘤学家传授开放临床试验的知识。八个项目组成部分和众多旨在促进临床试验的子组成部分已经进行了测试。包括：1)临床试验晚宴系列会议；2)地区癌症中心领导联盟；3)临床试验网站网络；4)随机试验评价临床试验信息传播方法；5)“触手可及”的数据库；6)研究驱动的社区外展计划；7)媒体合作；8)立法倡导的推动力。本提案将继续测试、发展、补充和报告这些不同项目组成部分在促进应计临床试验方面的有效性。对评估标准基础设施内干预措施影响的多种方法进行了测试，发现效果不佳。临床试验。基础设施已经进行了广泛的修订，以便在未来的工作中进行准确的端点评估。

The UCSD Cancer Center is an Organized Research Unit of the University of California, San Diego. It is comprised of over 120 members with academic appointments in 15 university departments, plus several members from other academic and research institutions throughout the region. Its mission is to reduce the incidence of, and morbidity and mortality from, cancer. The Cancer Center has had continuous funding as an NCI designated cancer center since April 1, 1979 and is oriented toward excellent basic, translational, behavioral, and clinical research. The low clinical trials accrual rates nationwide are recognized as a major barrier to achieving the rapid progress desired in the prevention, diagnosis, and treatment of cancer. The accrual of a representative sample of women and members of minority groups to clinical trials has been even more difficult to accomplish, limiting the broad applicability of these research findings. Over the past five years, UCSD Cancer Center has developed and pilotlested various components of a region wide infrastructure designed to reduce oncologists' barriers to clinical trials referral and to educate community oncologists about open clinical trials. Eight program components and numerous sub-components aimed at promoting clinical trials accrual have been tested. They include: 1) The Clinical Trials Dinner Meeting Series; 2) the Consortium of Regional Cancer Center Leaders; 3) a network of clinical trials web sites; 4) a randomized trial to evaluate methods to disseminate clinical trials information; 5) an "in- reach" data base; 6) research-driven community outreach programs; 7) a media partnership; and 8) a legislative advocacy thrust. This proposal will continue to test, develop, supplement, and report upon the effectiveness of these various program components in promoting accrual to clinical trials. Multiple approaches to assess the impact of the interventions within standard infrastructure were tested and found to be ineffective. The clinical trials. infrastructure has had extensive revisions to allow for accurate endpoint assessment with future efforts.