Mercury, Arsenic, and Carotid Atherosclerosis

汞、砷和颈动脉粥样硬化

• 批准号: 6706609
• 负责人: Eliseo Guallar
• 金额: $ 38.54万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-13 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6706609
• 关键词: activation analysis; arsenic; atherosclerosis; cardiotoxin; cardiovascular disorder epidemiology; cardiovascular disorder risk; carotid artery; clinical research; diet; environmental exposure; fish; human subject; longitudinal human study; mercury poisoning; nutrition related tag; omega 3 fatty acid; ultrasonography

DESCRIPTION (provided by applicant): Background: The cardiovascular consequences of long-term exposure to low concentrations of mercury or arsenic are insufficiently understood. Mercury has been linked to cardiovascular risk in some, but not all, studies, and its association with the progression of atherosclerosis is uncertain. High arsenic exposure is an established cause of vascular disease, but the effect of low concentrations, more typical of the exposure of the US population, is essentially unknown. Since fish intake is the main source of methylmercury exposure in the general population, and a major source of organic arsenic compounds, the effects of these compounds may be confounded by the cardioprotective n-3 fatty acids in fish. Objective: To investigate the association of mercury and arsenic exposure with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a cohort of individuals followed during 1989-99. Hypothesis: Exposure to mercury or arsenic, as determined in toenails, are associated with baseline carotid IMT and with its progression over 10 years follow-up. These associations are independent of established coronary risk factors and of plasma phospholipid long-chain n-3 fatty acids, a biomarker of fish oil intake. Setting: Cohort of 2,085 men and women, aged 45 years and older and residents in Washington County, MD, who participated simultaneously in the CLUE II cohort (that collected toenail clippings) and either in ARIC or in the CHS cohorts (that measured IMT and cardiovascular risk factors). Design and measurements: Prospective longitudinal study of the association of baseline mercury and arsenic levels with carotid IMT progression over 10 years. Toenail mercury and arsenic will be measured by instrumental neutron activation analysis, and plasma n-3 fatty acids by capillary gas chromatography. Carotid IMT has already been measured by B-mode ultrasound. Statistical analysis plan: Longitudinal data analysis methods will be used to model IMT progression. Important statistical issues will be the control of measurement error in repeated IMT measurements, the control of the effect of cardiovascular risk factors on IMT progression, and the evaluation of the joint effect of mercury or arsenic and n-3 fatty acids. Relevance: Confirmation of the role of mercury or arsenic on atherogenesis could impact current environmental and dietary public health recommendations.

描述（由申请人提供）：背景：长期暴露于低浓度汞或砷的心血管后果尚未得到充分了解。汞与心血管风险在一些但不是全部研究中有关，其与动脉粥样硬化进展的关系尚不确定。高砷暴露是血管疾病的既定原因，但低浓度的影响，更典型的美国人口的暴露，基本上是未知的。由于鱼类摄入是一般人群接触甲基汞的主要来源，也是有机砷化合物的主要来源，这些化合物的影响可能会被鱼类中保护心脏的n-3脂肪酸混淆。 目的：研究汞和砷暴露与颈动脉内膜中层厚度（IMT）的关系，IMT是亚临床动脉粥样硬化的标志物，在1989-99年随访的一组个体中进行。 假设：暴露于汞或砷，如确定在脚趾甲，与基线颈动脉IMT和其进展超过10年的后续行动。这些关联独立于已建立的冠状动脉危险因素和血浆磷脂长链n-3脂肪酸（鱼油摄入的生物标志物）。 设定：队列2,085名男性和女性，年龄在45岁及以上，居住在马里兰州华盛顿县，他们同时参加了CLUE II队列（收集趾甲剪）和ARIC或CHS队列（测量IMT和心血管风险因素）。 设计和测量：10年内基线汞和砷水平与颈动脉IMT进展相关性的前瞻性纵向研究趾甲汞和砷将通过仪器中子活化分析测量，血浆n-3脂肪酸通过毛细管气相色谱法测量。 颈动脉IMT已经通过B超测量。统计分析计划：将使用纵向数据分析方法对IMT进展进行建模。重要的统计学问题将是控制重复IMT测量中的测量误差，控制心血管危险因素对IMT进展的影响，以及评估汞或砷和n-3脂肪酸的联合作用。 相关性：确认汞或砷在动脉粥样硬化形成中的作用可能会影响目前的环境和饮食公共卫生建议。