Smoking Cessation Intervention for Depressed Smokers: Treatment Development

抑郁吸烟者的戒烟干预：治疗开发

• 批准号: 7145714
• 负责人: JANICE Anita BLALOCK
• 金额: $ 34.65万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7145714
• 关键词: behavior therapy; behavioral /social science research tag; cancer prevention; clinical research; combination therapy; comorbidity; human subject; human therapy evaluation; longitudinal human study; major depression; mental disorder diagnosis; nicotine replacement; smoking cessation; social psychology; substance abuse related behavior; transdermal drug delivery

DESCRIPTION (provided by applicant): The development of effective smoking cessation treatments for smokers with current depression may have important clinical and public health significance in reducing the overall morbidity and mortality associated with smoking. A disproportionate number of Americans who die each year from smoking-related causes have a lifetime history of major depressive disorder, and depression is strongly associated with increased medical morbidity and mortality. It seems likely that smokers with co-occurring depression may be among those at greatest risk for developing smoking-related medical disorders. Because smoking cessation treatment studies have traditionally excluded smokers with current major depressive disorder (MOD), very little is known regarding the impact of more severe depressive symptoms on smoking cessation outcome. However, there is a good deal of data showing that subsyndromal levels of depressive symptoms are predictive of smoking cessation failure. Depressive symptoms in smokers with current depressive disorders may pose even greater obstacles to abstinence. These individuals may require additional treatment that targets their depressive symptoms before they will be successful in achieving abstinence. The goal of this study is to provide a preliminary test of the effect of cognitive behavioral analysis system of psychotherapy (CBASP), an existing treatment that has been found to be efficacious in the treatment of chronic depression, in combination with standard smoking cessation treatment (CBASP/ST), on both short and long-term point prevalence abstinence in smokers with current MOD. Sixty smokers with current MOD will be recruited and randomly assigned to either the CBASP/ST treatment or standard smoking cessation treatment alone (ST). The nicotine patch will be included as part of standard treatment in both conditions. Based on the outcome of this preliminary trial, the CBASP/ST treatment protocol will be further refined and readied for larger-scale clinical trials.

描述（由申请方提供）：针对目前患有抑郁症的吸烟者开发有效的戒烟治疗，可能对降低吸烟相关的总体发病率和死亡率具有重要的临床和公共卫生意义。每年死于吸烟相关原因的美国人中，有不成比例的人一生都有重度抑郁症的病史，抑郁症与医疗发病率和死亡率的增加密切相关。吸烟者与抑郁症并存的人可能是患吸烟相关疾病的最大风险人群。由于戒烟治疗研究传统上排除了患有重度抑郁症（MOD）的吸烟者，因此关于更严重的抑郁症状对戒烟结果的影响知之甚少。然而，有大量的数据表明，抑郁症状的亚综合征水平是戒烟失败的预测。患有抑郁症的吸烟者的抑郁症状可能会对戒烟造成更大的障碍。这些人可能需要额外的治疗，针对他们的抑郁症状，然后才能成功实现禁欲。本研究的目的是提供一个初步的测试效果的认知行为分析系统的心理治疗（CBASP），现有的治疗已被发现是有效的治疗慢性抑郁症，结合标准的戒烟治疗（CBASP/ST），在短期和长期-将招募60名患有当前MOD的吸烟者，并随机分配至CBASP/ST治疗或单独标准戒烟治疗（ST）。尼古丁贴片将作为两种情况下标准治疗的一部分。根据这项初步试验的结果，CBASP/ST治疗方案将进一步完善，并为更大规模的临床试验做好准备。