Neuroimaging Studies of Depression in Parkinson's Disease

帕金森病抑郁症的神经影像学研究

• 批准号: 7151841
• 负责人: Lee Xenakis Blonder
• 金额: $ 36.63万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7151841
• 关键词: Parkinson' s disease; amygdala; antiparkinson drugs; behavioral /social science research tag; bioimaging /biomedical imaging; brain disorder chemotherapy; brain mapping; brain morphology; caudate nucleus; cingulate gyrus; clinical research; cognition; depression; dopamine agonists; emotions; face expression; frontal lobe /cortex; human middle age (35-64); human old age (65+); human subject; neuroimaging; neuropathology; neuropharmacology; patient oriented research

DESCRIPTION (provided by applicant): Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in verbal fluency, set shifting, confrontation naming, and memory relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). Our primary hypothesis is that depression in PD is linked to structural and functional abnormality in dorsal and ventral striatum, amygdala, orbitofrontal cortex, medial frontal cortex, and anterior cingulate. Based on this, we predict that in comparisons with non-depressed PD patients, PD patients with depression will show 1.) significant reductions in the volume of the caudate nucleus, orbitofrontal cortex, medial frontal cortex, anterior cingulate, and amygdala; and 2.) reduced activation on cognitive and emotional tasks known to engage these regions. Our secondary hypothesis is that anti-parkinsonian medications, particularly D2/D3 receptor agonists, will result in elevation in mood and increased activation in these brain regions among depressed PD patients during the performance of cognitive and emotional tasks. To delineate the neural substrates of Parkinsonian depression, each patient and control will undergo neuropsychological testing and structural and functional MRI. We will compare regional brain volume in structures associated with depression and patterns of functional MRI activation during working memory and facial affect processing tasks. Neuropsychological testing and fMRI will be performed "on" and "off dopaminergic pharmacotherapy in PD patients and at two similar time points in the unmedicated control group. The research proposed herein will contribute to our understanding of the neural pathways that underlie depression in PD, the relationship of dysphoria to cerebral activation during cognitive and affective processing, and the effects of dopaminergic pharmacotherapy on brain response in prefrontal and limbic regions.

描述（由申请人提供）：抑郁症是帕金森氏病（PD）的常见且可能严重的并发症。研究表明，大约40％的PD患者抑郁症。有证据表明，相对于不抑郁的PD患者，这些患者的言语流利性，设定转移，对抗命名和记忆力不足。尽管PD对情绪健康产生了广泛的影响，但很少有研究对帕金森氏抑郁症的神经基础进行了全面的检查。在这个项目中，我们将使用神经心理学评估和磁共振成像（MRI）将抑郁症与未抑郁的帕金森患者与人口统计学匹配的健康对照样本进行比较。我们的主要假设是，PD中的抑郁与背侧和腹侧纹状体，杏仁核，甲状腺皮质，内侧额叶皮质和前扣带回的结构和功能异常有关。基于此，我们预测，在与未抑郁的PD患者的比较中，PD患者将显示1.）尾状核，眶额皮层，内侧额叶皮层，前扣带回和杏仁核的体积显着减少；和2.）减少了已知参与这些区域的认知和情感任务的激活。我们的次要假设是，在认知和情感任务执行时，抗原药物，尤其是D2/D3受体激动剂，将导致抑郁症PD患者的情绪升高和增加的激活。为了描绘帕金森氏抑郁症的神经底物，每个患者和控制都会接受神经心理学测试以及结构和功能性MRI。我们将比较与抑郁症和功能性MRI激活模式相关的结构中的区域大脑体积，并且面部影响处理任务。 Neuropsychological testing and fMRI will be performed "on" and "off dopaminergic pharmacotherapy in PD patients and at two similar time points in the unmedicated control group. The research proposed herein will contribute to our understanding of the neural pathways that underlie depression in PD, the relationship of dysphoria to cerebral activation during cognitive and affective processing, and the effects of dopaminergic pharmacotherapy on前额叶和边缘区域的大脑反应。