Developmental Research Program

项目摘要/摘要 66路子宫内膜癌孢子发育研究计划(DRP)的总体目标是 支持子宫内膜癌的创新早期研究，开发试点项目，以达到 包括作为完整的孢子项目，以增加致力于子宫内膜癌的调查人员的数量， 并使劳动力多样化。最后一个目标很重要，因为只有不到3%的肿瘤学家和不到 4%的学院派产科医生和妇科医生认为自己是黑人。此外，尽管其中80%以上的人 在产科和妇科工作的是女性，只有不到30%的系内终身教职员工 妇产科的专家都是女性。为了实现这些目标，66号道路子宫内膜癌孢子 DRP将提供一到两年的试点资金，用于基础、翻译、临床、流行病学和 癌症预防和控制研究。参与计划的三所院校均可参加 孢子(位于圣路易斯的华盛顿大学、新墨西哥大学和俄克拉何马大学)。我们会 鼓励调查人员与其他孢子的调查人员提交合作建议。我们将使用 NCI和机构资金，在整个生命周期内每年支持最多三个DRP项目 孢子。子宫内膜癌研究中DRP项目的申请将于每年发布一次 年。所有申请将由一个由科学家组成的拨款审查委员会(代表 基础科学和应用科学)拥有子宫内膜癌或相关癌症或相关科学的专业知识，a 生物统计学家、患者权益倡导者和必要时的特别成员。一旦DRP项目获得资金，我们将 提供专门的支持以确保项目的成功，定期评估进度，评估结果，以及 决定是否建议在今年或将来将DRP项目作为完整的孢子项目提供资金 资金周期。作为DRP的结果，子宫内膜癌研究中的大胆新想法将在试点中获得资助 发展到新的治疗或预防策略。我们完全预计会有一个或多个 DRP项目将在下一个资助期提升为全孢子项目。此外，新的调查人员 将利用DRP支持来开发他们的项目，获取初步数据，并获得外部资金和 从而奠定了他们在子宫内膜癌研究方面的职业生涯。最后，新手的老牌调查人员 该领域将把他们的知识和专业知识应用于子宫内膜癌领域。

PROJECT SUMMARY/ ABSTRACT The overall goals of the Route 66 Endometrial Cancer SPORE Developmental Research Program (DRP) are to support innovative, early-stage research in endometrial cancer, to develop pilot projects to the point of inclusion as full SPORE projects, to increase the number of investigators committed to endometrial cancer, and to diversify the workforce. This last goal is important because less than 3% of oncologists and less than 4% of academic obstetricians and gynecologist identify as Black. Moreover, although over 80% of those working in obstetrics and gynecology are women, fewer than 30% of tenured faculty members in Departments of Obstetrics and Gynecology are women. To achieve these goals, the Route 66 Endometrial Cancer SPORE DRP will provide one- to two-year pilot funding for projects in basic, translational, clinical, epidemiologic, and cancer prevention and control research. The DRP will be open to all three participating institutions in the SPORE (Washington University in St. Louis, University of New Mexico, and University of Oklahoma). We will encourage investigators to submit collaborative proposals with investigators from other SPOREs. We will use both NCI and institutional funding to support up to three DRP projects each year throughout the life of the SPORE. Requests for applications for DRP projects in endometrial cancer research will be released once per year. All applications will be reviewed by a Grant Review Committee consisting of scientists (representing basic and applied science) with expertise in endometrial or related cancers or relevant science, a biostatistician, a patient advocate, and ad hoc members, as necessary. Once a DRP project is funded, we will provide dedicated support to ensure success of the project, evaluate progress regularly, assess outcomes, and decide whether DRP projects should be recommended for funding as a full SPORE project in this or a future funding cycle. As a result of the DRP, bold new ideas in endometrial cancer research will be funded at the pilot stage and developed to lead to new treatment or prevention strategies. We fully anticipate that one or more DRP projects will be elevated to full SPORE projects in the next funding period. Additionally, new investigators will leverage DRP support to develop their projects, obtain preliminary data, and secure external funding and thus establish their careers in endometrial cancer research. Finally, established investigators who are new to the field will apply their knowledge and expertise to the field of endometrial cancer.