Developmental Research Program

项目概要/摘要 66号公路子宫内膜癌孢子发育研究计划（DRP）的总体目标是 支持子宫内膜癌的创新性早期研究，开发试点项目， 纳入完整的SPORE项目，以增加致力于子宫内膜癌的研究人员数量， 并使劳动力多样化。这最后一个目标很重要，因为只有不到3%的肿瘤学家和不到10%的 4%的学术产科医生和妇科医生认为自己是黑人。此外，尽管超过80%的 在妇产科工作的是女性，在系里终身教职的成员不到30%， 都是女性为了实现这些目标，路线66子宫内膜癌孢子 DRP将为基础、转化、临床、流行病学和 癌症预防和控制研究。计划将开放予三间参与院校参加， 孢子（华盛顿圣路易斯大学，新墨西哥州大学和俄克拉荷马州大学）。我们将 鼓励研究者与其他SPORE的研究者提交合作提案。我们将使用 NCI和机构资金，以支持多达三个DRP项目，每年在整个生命周期， 孢子。关于子宫内膜癌研究DRP项目的申请， 年所有申请将由一个由科学家组成的资助审查委员会审查（代表 基础和应用科学），具有子宫内膜癌或相关癌症或相关科学的专业知识， 生物统计学家、患者倡导者和临时成员（如必要）。一旦DRP项目获得资助，我们将 提供专门的支持，以确保项目的成功，定期评估进展情况，评估成果， 决定DRP项目是否应在当前或将来作为一个完整的SPORE项目推荐供资 融资周期。作为DRP的结果，子宫内膜癌研究中大胆的新想法将在试点中获得资助 阶段和发展导致新的治疗或预防策略。我们完全预计， 在下一个资助期内，DRP项目将提升为完整的SPORE项目。此外，新的调查人员 将利用DRP支持来开发项目，获得初步数据，并获得外部资金， 从而在子宫内膜癌研究中建立自己的职业生涯。最后，新成立的调查人员 该领域将把他们的知识和专业知识应用于子宫内膜癌领域。

PROJECT SUMMARY/ ABSTRACT The overall goals of the Route 66 Endometrial Cancer SPORE Developmental Research Program (DRP) are to support innovative, early-stage research in endometrial cancer, to develop pilot projects to the point of inclusion as full SPORE projects, to increase the number of investigators committed to endometrial cancer, and to diversify the workforce. This last goal is important because less than 3% of oncologists and less than 4% of academic obstetricians and gynecologist identify as Black. Moreover, although over 80% of those working in obstetrics and gynecology are women, fewer than 30% of tenured faculty members in Departments of Obstetrics and Gynecology are women. To achieve these goals, the Route 66 Endometrial Cancer SPORE DRP will provide one- to two-year pilot funding for projects in basic, translational, clinical, epidemiologic, and cancer prevention and control research. The DRP will be open to all three participating institutions in the SPORE (Washington University in St. Louis, University of New Mexico, and University of Oklahoma). We will encourage investigators to submit collaborative proposals with investigators from other SPOREs. We will use both NCI and institutional funding to support up to three DRP projects each year throughout the life of the SPORE. Requests for applications for DRP projects in endometrial cancer research will be released once per year. All applications will be reviewed by a Grant Review Committee consisting of scientists (representing basic and applied science) with expertise in endometrial or related cancers or relevant science, a biostatistician, a patient advocate, and ad hoc members, as necessary. Once a DRP project is funded, we will provide dedicated support to ensure success of the project, evaluate progress regularly, assess outcomes, and decide whether DRP projects should be recommended for funding as a full SPORE project in this or a future funding cycle. As a result of the DRP, bold new ideas in endometrial cancer research will be funded at the pilot stage and developed to lead to new treatment or prevention strategies. We fully anticipate that one or more DRP projects will be elevated to full SPORE projects in the next funding period. Additionally, new investigators will leverage DRP support to develop their projects, obtain preliminary data, and secure external funding and thus establish their careers in endometrial cancer research. Finally, established investigators who are new to the field will apply their knowledge and expertise to the field of endometrial cancer.