Training in Translational Science and Cardiovascular Research

摘要 该提案寻求对心血管转化研究中完善的培训计划的支持， 俄勒冈州健康与科学大学（OHSU）的医学博士和博士博士后研究员。培训计划有 具有悠久的培训历史，是教育和培训活动的重要组成部分， 骑士心血管研究所在过去的十年里，该计划培养了许多研究员，他们 在学术界获得独立地位。我们的受训者中， 以及女性和医学博士和博士，包括来自代表性不足的少数群体的研究员。我们要求 每年资助6名博士后研究员（3个职位，每个职位两年）。该计划提供令人兴奋的 有机会在三个已建立的培训中心之一进行从板凳到床边的多学科培训， 擅长：1）心血管调节，包括生理调节，缺血-再灌注， 高血压，2）心血管炎症，其包括动脉粥样硬化、糖尿病、血栓形成和病毒感染。 与心血管疾病（包括COVID-19）相关的感染，以及3）心血管 发展，其中包括心血管遗传学，基因组学和胎儿编程。教师导师 是高度认可和资助的科学家，他们在培养博士后研究员方面有着良好的记录。的 该计划是高度跨学科的，导师的专业知识涵盖了广泛的翻译范围。 实验室研究是由课程工作，研讨会，杂志俱乐部，并在一个特定的会议补充 科学组。课程包括研究设计，生物统计学，心血管生理学和遗传学。所有 学员参加负责任的研究培训、科学写作、创业和团队活动 科学和领导力培训。该计划在OHSU是独一无二的，因为指导是由一个 多学科团队，因为培训是专门设计来翻译基础心血管研究 转化为临床效益主要指导者将由至少两名共同指导者协助，他们补充主要指导者。 通过带来临床、基础科学或技术专业知识来发挥导师的专业知识。培训结果将是 科学家具有广阔的视野，并专注于将科学带到床边。该应用程序包括一个强大的 为得不到充分服务的少数族裔受训人员制定征聘计划，并开展评价工作。项目咨询委员会 监控每个学员的进度，因为他们满足特定的里程碑，为研究生涯做准备。在 总之，拟议的心血管研究培训计划将提供一个独特的机会， 多学科培训，成功的学员将有能力开始独立的研究生涯 转化性心血管研究。

ABSTRACT This proposal seeks support for a well-established training program in translational cardiovascular research for MD and PhD postdoctoral fellows at Oregon Health & Science University (OHSU). The training program has a long history of training excellence and is an essential component of the educational and training activities of The Knight Cardiovascular Institute. Over the past decade, the program has trained many fellows, who have been successful in obtaining independent positions in academics. Our trainees included equal numbers of men and women and MDs and PhDs, and included fellows from under-represented minority groups. We request funding for 6 post-doctoral fellows per year (3 positions for two years each). The program offers exciting opportunities for bench to bedside, multidisciplinary training in one of three established Training Hubs that specialize in: 1) Cardiovascular Regulation, which includes physiological regulation, ischemia-reperfusion and hypertension, 2) Cardiovascular Inflammation, which includes atherosclerosis, diabetes, thrombosis, and viral infections with relevance to cardiovascular disease (including COVID-19), and 3) Cardiovascular Development, which includes cardiovascular genetics, genomics and fetal programming. The faculty mentors are highly recognized and funded scientists who have a strong track record of training postdoctoral fellows. The program is highly interdisciplinary and mentors' expertise cover a wide range of the translational spectrum. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. Course work includes research design, biostatistics, cardiovascular physiology and genetics. All trainees participate in responsible conduct of research training, scientific writing, entrepreneurship and team science and leadership training. This program is unique at OHSU in that mentoring is carried out by a multidisciplinary team, and because training is specifically designed to translate basic cardiovascular research into clinical benefit. The primary mentor will be assisted by at least two co-mentors, who complement the primary mentor's expertise by bringing clinical, basic science or technical expertise. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment plan for underserved minority trainees and an evaluation process. A Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. In summary, the proposed cardiovascular research training program will provide a unique opportunity for multidisciplinary training, and successful trainees will be well equipped to initiate independent research careers in translational cardiovascular research.