Training in Translational Science and Cardiovascular Research

摘要 这项提案寻求对转换心血管研究中成熟的培训计划的支持 俄勒冈健康与科学大学(OHSU)医学博士和博士后研究员。培训计划有 优秀的培训历史悠久，是联合国教育和培训活动的重要组成部分 骑士心血管研究所。在过去的十年里，该计划培训了许多研究员，他们已经 成功地在学术界获得了独立的职位。我们的受训人员中有相同数量的男性 以及妇女、医学博士和博士，并包括来自代表性不足的少数群体的研究员。我们请求 每年资助6名博士后研究员(每个职位3个，为期两年)。该节目提供了激动人心的 板凳到床边的机会，在三个成熟的培训中心之一进行多学科培训， 擅长：1)心血管调节，包括生理调节、缺血再灌注和 高血压，2)心血管炎症，包括动脉粥样硬化、糖尿病、血栓形成和病毒感染 与心血管疾病相关的感染(包括新冠肺炎)，以及3)心血管疾病 发展，包括心血管遗传学、基因组学和胎儿编程。教员导师 都是高度认可和资助的科学家，他们在培训博士后研究员方面有很好的记录。这个 该计划是高度跨学科的，导师的专业知识涵盖了广泛的翻译领域。 实验室研究通过课程作业、研讨会、期刊俱乐部和特定学科的会议来补充。 科学小组。课程包括研究设计、生物统计学、心血管生理学和遗传学。全 学员参与负责任的研究培训、科学写作、创业和团队活动 科学和领导力培训。这一计划在OHSU是独一无二的，因为指导由一名 多学科团队，因为培训是专门为转化基础心血管研究而设计的 转化为临床益处。初级导师将得到至少两名共同导师的协助，他们是初级导师的补充。 通过带来临床、基础科学或技术专业知识来指导导师的专业知识。培训结果将是 具有广阔视野和专注于将科学带到床边的科学家。该应用程序包括一个强大的 服务不足的少数族裔受训人员的招聘计划和评估程序。计划咨询委员会 监督每一位学员在达到为研究生涯做准备的特定里程碑时的进度。在……里面 综上所述，拟议的心血管研究培训计划将为 多学科培训，成功的受训者将为开始独立研究生涯做好准备 在转化性心血管研究中。

ABSTRACT This proposal seeks support for a well-established training program in translational cardiovascular research for MD and PhD postdoctoral fellows at Oregon Health & Science University (OHSU). The training program has a long history of training excellence and is an essential component of the educational and training activities of The Knight Cardiovascular Institute. Over the past decade, the program has trained many fellows, who have been successful in obtaining independent positions in academics. Our trainees included equal numbers of men and women and MDs and PhDs, and included fellows from under-represented minority groups. We request funding for 6 post-doctoral fellows per year (3 positions for two years each). The program offers exciting opportunities for bench to bedside, multidisciplinary training in one of three established Training Hubs that specialize in: 1) Cardiovascular Regulation, which includes physiological regulation, ischemia-reperfusion and hypertension, 2) Cardiovascular Inflammation, which includes atherosclerosis, diabetes, thrombosis, and viral infections with relevance to cardiovascular disease (including COVID-19), and 3) Cardiovascular Development, which includes cardiovascular genetics, genomics and fetal programming. The faculty mentors are highly recognized and funded scientists who have a strong track record of training postdoctoral fellows. The program is highly interdisciplinary and mentors' expertise cover a wide range of the translational spectrum. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. Course work includes research design, biostatistics, cardiovascular physiology and genetics. All trainees participate in responsible conduct of research training, scientific writing, entrepreneurship and team science and leadership training. This program is unique at OHSU in that mentoring is carried out by a multidisciplinary team, and because training is specifically designed to translate basic cardiovascular research into clinical benefit. The primary mentor will be assisted by at least two co-mentors, who complement the primary mentor's expertise by bringing clinical, basic science or technical expertise. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment plan for underserved minority trainees and an evaluation process. A Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. In summary, the proposed cardiovascular research training program will provide a unique opportunity for multidisciplinary training, and successful trainees will be well equipped to initiate independent research careers in translational cardiovascular research.