Training in Translational Science and Cardiovascular Research

转化科学和心血管研究培训

• 批准号: 10711526
• 负责人: Nabil J Alkayed
• 金额: $ 52.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711526
• 关键词: Cardiovascular system; Research; Training; Translational Research

ABSTRACT This proposal seeks support for a well-established training program in translational cardiovascular research for MD and PhD postdoctoral fellows at Oregon Health & Science University (OHSU). The training program has a long history of training excellence and is an essential component of the educational and training activities of The Knight Cardiovascular Institute. Over the past decade, the program has trained many fellows, who have been successful in obtaining independent positions in academics. Our trainees included equal numbers of men and women and MDs and PhDs, and included fellows from under-represented minority groups. We request funding for 6 post-doctoral fellows per year (3 positions for two years each). The program offers exciting opportunities for bench to bedside, multidisciplinary training in one of three established Training Hubs that specialize in: 1) Cardiovascular Regulation, which includes physiological regulation, ischemia-reperfusion and hypertension, 2) Cardiovascular Inflammation, which includes atherosclerosis, diabetes, thrombosis, and viral infections with relevance to cardiovascular disease (including COVID-19), and 3) Cardiovascular Development, which includes cardiovascular genetics, genomics and fetal programming. The faculty mentors are highly recognized and funded scientists who have a strong track record of training postdoctoral fellows. The program is highly interdisciplinary and mentors' expertise cover a wide range of the translational spectrum. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. Course work includes research design, biostatistics, cardiovascular physiology and genetics. All trainees participate in responsible conduct of research training, scientific writing, entrepreneurship and team science and leadership training. This program is unique at OHSU in that mentoring is carried out by a multidisciplinary team, and because training is specifically designed to translate basic cardiovascular research into clinical benefit. The primary mentor will be assisted by at least two co-mentors, who complement the primary mentor's expertise by bringing clinical, basic science or technical expertise. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment plan for underserved minority trainees and an evaluation process. A Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. In summary, the proposed cardiovascular research training program will provide a unique opportunity for multidisciplinary training, and successful trainees will be well equipped to initiate independent research careers in translational cardiovascular research.

抽象的 该建议寻求支持一项公认的培训计划，以进行转化心血管研究 俄勒冈州健康与科学大学（OHSU）的医学博士和博士博士后研究员。培训计划有 卓越训练的悠久历史，是教育和培训活动的重要组成部分 骑士心血管研究所。在过去的十年中，该计划训练了许多研究员 成功地获得了学者的独立职位。我们的学员包括同等数量的男人 以及妇女，医学博士和博士学位，包括来自代表性不足的少数群体的研究员。我们要求 每年6个博士后研究员的资金（每年3个职位，两年）。该计划提供令人兴奋的 在三个既定的培训中心之一中，卧床间，跨学科培训的机会 专门研究：1）心血管调节，其中包括生理调节，缺血 - 重新灌注和 高血压，2）心血管炎症，包括动脉粥样硬化，糖尿病，血栓形成和病毒 与心血管疾病相关的感染（包括Covid-19），3）心血管 开发，包括心血管遗传学，基因组学和胎儿编程。教师导师 是备受认可和资助的科学家，他们在训练博士后研究员方面具有良好的记录。这 计划是高度跨学科的，导师的专业知识涵盖了各种翻译光谱。 实验室研究补充了课程工作，研讨会，期刊俱乐部和特定的会议 科学小组。课程工作包括研究设计，生物统计学，心血管生理和遗传学。全部 学员参加了负责任的研究培训，科学写作，企业家精神和团队的行为 科学和领导培训。该程序在OHSU中是独一无二的，因为指导是由 多学科团队，并且因为培训是专门设计的，以翻译基本的心血管研究 进入临床益处。至少有两名副主导者将协助主要导师 通过带来临床，基础科学或技术专长，导师的专业知识。培训结果将是 具有广阔前景的科学家，专注于将科学带到床边。该应用程序包括一个强大的 服务不足的少数民族学员和评估过程的招聘计划。计划咨询委员会 在每个学员遇到特定的里程碑时，请监视每个学员的进步，以准备研究生涯。在 摘要，拟议的心血管研究培训计划将为 多学科培训和成功的学员将有能力启动独立的研究职业 在转化心血管研究中。