Xenobiotic-responsive hepatic long non-coding RNAs
Xenobiotic-responsive hepatic long non-coding RNAs
批准号:
10711162
负责人:
DAVID J WAXMAN
金额:
$3.49万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-12-16 至 2025-04-30
关键词:
AddressAdultAffectAgonistArchitectureAutomobile DrivingAwardBioinformaticsBiological ProcessCRISPR interferenceCell CommunicationCellsChemicalsCodeData AnalysesDevelopmentDietDietary FatsDiseaseDisease ProgressionEducational StatusEpigenetic ProcessEtiologyEvaluationExposure toGene Expression ProfileGenesGenetic TranscriptionHealthHepaticHepatocyteHigh Fat DietKnockout MiceLigandsLinkLiverLiver CirrhosisLiver FibrosisLiver diseasesMediatorMentorsMetabolic PathwayMitochondriaModelingMolecularMusNuclear ReceptorsParentsPathologicPathologyPathway interactionsPhysiologicalPositioning AttributePrimary carcinoma of the liver cellsProcessProteinsQualifyingRNARegimenResearchResearch TrainingRoleSchemeSmall Nuclear RNASpecificityTechniquesTimeTrainingUnderrepresented MinorityUntranslated RNAXenobioticscell typedisorder riskdoctoral studentenvironmental chemicalenvironmental toxicologyepigenome editingexperiencefatty liver diseasegene networkimmune cell infiltratein vivoinsightinterestlaboratory experimentlipid metabolismliver metabolismmouse modelnon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnovel markerparent grantprogramspromoterprototypereceptortherapeutic targettranscription factortranscription terminationtranscriptome sequencingtranscriptomic profilingunderrepresented minority student
中文摘要
多样性补充申请-ES 024421,Waxman DJ,PI
项目摘要/摘要-此申请是为了促进研究补充
健康相关研究的多样性(PA-21-071),以支持合格的代表性不足
少数民族博士生谁将接受研究生水平的培训,在分子环境
毒理学研究,ES 024421。拟议的培训和指导方案将
使用小鼠模型来推进我们对核受体相互作用的理解
当被外来的环境化学物质激活时,
方案,重点是影响脂肪肝发生和进展的相互作用,
肝脏疾病这些研究密切相关,并将大大推动进展
根据家长补助金,并将提供合格的代表性不足的少数民族博士生
在广泛的湿实验室实验,数据分析和
生物信息学技术解决分子生物学前沿研究问题
环境毒理学
英文摘要
Diversity Supplement Application – ES024421, Waxman DJ, PI
Project Summary/Abstract - This application is for a Research Supplement to Promote
Diversity in Health-Related Research (PA-21-071) in support of a qualified underrepresented
minority PhD student who will receive graduate level training in molecular environmental
toxicology under parent grant, ES024421. The proposed training and mentoring program will
use the mouse model to advance our understanding of the interactions of nuclear receptors
when activated by foreign, environmental chemicals, with exposure to high fat dietary
regimens, with a focus on interactions that impact the development and progression of fatty
liver disease. These studies are closely related to, and will significantly advance progress
under the parent grant, and will provide the qualified underrepresented minority PhD student
with training and experience in a broad range of wet lab experimental, data analysis and
bioinformatics techniques to address cutting edge research problems in molecular
environmental toxicology.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Growth Hormone Regulation of Sex Differences in Liver Metabolism
-
批准号:9897015
-
项目类别:
-
资助金额:$49.11万
-
财政年份:2019
-
负责人:DAVID J WAXMAN
-
依托单位:
Growth Hormone Regulation of Sex Differences in Liver Metabolism
-
批准号:10626011
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项目类别:
-
资助金额:$49.63万
-
财政年份:2019
-
负责人:DAVID J WAXMAN
-
依托单位:
Growth Hormone Regulation of Sex Differences in Liver Metabolism
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批准号:10402862
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项目类别:
-
资助金额:$49.5万
-
财政年份:2019
-
负责人:DAVID J WAXMAN
-
依托单位:
Growth Hormone Regulation of Sex Differences in Liver Metabolism
-
批准号:10164773
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项目类别:
-
资助金额:$49.37万
-
财政年份:2019
-
负责人:DAVID J WAXMAN
-
依托单位:
Growth Hormone Regulation of Sex Differences in Liver Metabolism
-
批准号:10018890
-
项目类别:
-
资助金额:$50.31万
-
财政年份:2019
-
负责人:DAVID J WAXMAN
-
依托单位:
Xenobiotic-responsive hepatic long non-coding RNAs
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批准号:10809269
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项目类别:
-
资助金额:$7.78万
-
财政年份:2014
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负责人:DAVID J WAXMAN
-
依托单位:
Epigenetic Actions of Environmental Chemicals
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批准号:8762618
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项目类别:
-
资助金额:$40.39万
-
财政年份:2014
-
负责人:DAVID J WAXMAN
-
依托单位:
Xenobiotic-responsive hepatic long non-coding RNAs
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批准号:10615645
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项目类别:
-
资助金额:$47.2万
-
财政年份:2014
-
负责人:DAVID J WAXMAN
-
依托单位:
Xenobiotic-responsive hepatic long non-coding RNAs
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批准号:10394387
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项目类别:
-
资助金额:$47.2万
-
财政年份:2014
-
负责人:DAVID J WAXMAN
-
依托单位:
Xenobiotic-responsive hepatic long non-coding RNAs
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批准号:10210396
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项目类别:
-
资助金额:$47.2万
-
财政年份:2014
-
负责人:DAVID J WAXMAN
-
依托单位:
Xenobiotic-responsive hepatic long non-coding RNAs
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批准号:10058507
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项目类别:
-
资助金额:$47.2万
-
财政年份:2014
-
负责人:DAVID J WAXMAN
-
依托单位:
Cytochrome P450-Endogenous Substrate Metabolism
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批准号:8037913
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项目类别:
-
资助金额:$10.0万
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财政年份:2010
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负责人:DAVID J WAXMAN
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依托单位:
Epigenetic Marks of Xenoestrogen Exposure
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批准号:7941819
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项目类别:
-
资助金额:$41.06万
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财政年份:2009
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负责人:DAVID J WAXMAN
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依托单位:
Cytochrome P450-Endogenous Substrate Metabolism
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批准号:7992597
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项目类别:
-
资助金额:$9.59万
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财政年份:2009
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负责人:DAVID J WAXMAN
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依托单位:
Epigenetic Marks of Xenoestrogen Exposure
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批准号:8077724
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项目类别:
-
资助金额:$8.1万
-
财政年份:2009
-
负责人:DAVID J WAXMAN
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依托单位:
Epigenetic Marks of Xenoestrogen Exposure
-
批准号:7830420
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项目类别:
-
资助金额:$40.1万
-
财政年份:2009
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负责人:DAVID J WAXMAN
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依托单位:
Research Project 3: Nuclear Receptors and Gonadal Toxicity of Xenochemicals
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批准号:6901352
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项目类别:
-
资助金额:$21.42万
-
财政年份:2005
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负责人:DAVID J WAXMAN
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依托单位:
PPAR, hormones, and xenobiotics
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批准号:6664578
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项目类别:
-
资助金额:$13.44万
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财政年份:2002
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负责人:DAVID J WAXMAN
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依托单位:
PPAR, hormones, and xenobiotics
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批准号:6578802
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项目类别:
-
资助金额:$13.44万
-
财政年份:2002
-
负责人:DAVID J WAXMAN
-
依托单位:
PPAR, hormones, and xenobiotics
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批准号:6443953
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项目类别:
-
资助金额:$13.44万
-
财政年份:2001
-
负责人:DAVID J WAXMAN
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依托单位:
海外基金