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Xenobiotic-responsive hepatic long non-coding RNAs

Xenobiotic-responsive hepatic long non-coding RNAs
异生素反应性肝脏长非编码RNA
批准号:
10711162
负责人:
DAVID J WAXMAN
金额:
$3.49万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-12-16 至 2025-04-30

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中文摘要
翻译
多样性补充申请-ES 024421,Waxman DJ,PI 项目摘要/摘要-此申请是为了促进研究补充 健康相关研究的多样性(PA-21-071),以支持合格的代表性不足 少数民族博士生谁将接受研究生水平的培训,在分子环境 毒理学研究,ES 024421。拟议的培训和指导方案将 使用小鼠模型来推进我们对核受体相互作用的理解 当被外来的环境化学物质激活时, 方案,重点是影响脂肪肝发生和进展的相互作用, 肝脏疾病这些研究密切相关,并将大大推动进展 根据家长补助金,并将提供合格的代表性不足的少数民族博士生 在广泛的湿实验室实验,数据分析和 生物信息学技术解决分子生物学前沿研究问题 环境毒理学
英文摘要
Diversity Supplement Application – ES024421, Waxman DJ, PI Project Summary/Abstract - This application is for a Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) in support of a qualified underrepresented minority PhD student who will receive graduate level training in molecular environmental toxicology under parent grant, ES024421. The proposed training and mentoring program will use the mouse model to advance our understanding of the interactions of nuclear receptors when activated by foreign, environmental chemicals, with exposure to high fat dietary regimens, with a focus on interactions that impact the development and progression of fatty liver disease. These studies are closely related to, and will significantly advance progress under the parent grant, and will provide the qualified underrepresented minority PhD student with training and experience in a broad range of wet lab experimental, data analysis and bioinformatics techniques to address cutting edge research problems in molecular environmental toxicology.
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