Mechanistic and functional characterization of the atypical kinase SgK269

非典型激酶 SgK269 的机制和功能表征

• 批准号: nhmrc : 1054497
• 负责人: Dr Ling Liu
• 金额: $ 18.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-functional-characterization-kinase-sgk269/112395
• 关键词: Mechanistic; functional; characterization; atypical; kinase

The overall aim of this study is to characterize at a mechanistic and functional level the oncogenic role of SgK269. We will use quantitative proteomics and phosphoproteomics to characterize the signaling network role of SgK269 and subsequently undertake a detailed structure/function analysis of SgK269 in mammary epithelial cells. Our study will provide novel insights into the signaling mechanism and function of SgK269 and highlight the potential strategies for improved treatment of basal breast cancers.

本研究的总体目的是在机制和功能水平上表征SgK269的致癌作用。我们将使用定量蛋白质组学和磷酸化蛋白质组学来表征SgK269的信号网络作用，随后对SgK269在乳腺上皮细胞中的结构/功能进行详细分析。我们的研究将为SgK269的信号机制和功能提供新的见解，并强调改善基底乳腺癌治疗的潜在策略。