Psychological consequences of medical transition in transgender youth

跨性别青年医疗转型的心理后果

基本信息

批准号：
10710381
负责人：
Natalie Wittlin
金额：
$ 6.93万
依托单位：
PRINCETON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10710381
关键词：
Academy Adolescent Age American American Medical Association Anxiety Appearance Birth Body Image Breast Childhood Clinic Clinical Psychology Communities Depersonalization Development Dimensions Distress Endocrine Endocrinologist Ethics Face Feeling Fellowship Feminization Gender Gender Identity Goals Guidelines Hair Hormones Human Individual Intervention Knowledge Literature Longitudinal Studies Measures Mediating Medical Mental Depression Mental Health Mental disorders Mentorship Methodology Monitor Outcome Participant Pediatrics Personal Satisfaction Pharmaceutical Preparations Policies Population Provider Psychopathology Puberty Publications Publishing Research Robin bird Running Sampling Sex Characteristics Siblings Training US State Universities Work Youth body dissatisfaction cisgender comparison group experience gender affirmation gender affirming hormone therapy health disparity hormone therapy improved peer psychologic puberty blocker reducing suicide satisfaction self esteem social statistics suicidal risk transgender

项目摘要

Project Summary/Abstract Transgender youth experience higher levels of mental illness than their cisgender (i.e., non-transgender) peers. One proposed contributor to these high rates of mental illness is the discordance transgender youth experience between their bodies and appearances, on one hand, and their gender identities, on the other. Medical organizations have suggested that endocrine interventions—specifically puberty suppression and hormone therapy—can improve mental health in transgender youth by halting the development of gender- incongruent secondary sex characteristics and producing gender-congruent secondary sex characteristics, respectively. Yet legislators throughout the US have recently introduced bills that would ban transgender youth from accessing puberty suppression and hormone therapy, asserting that these interventions are not psychologically beneficial. Five studies to date have longitudinally examined the relationship between one or both of these interventions and mental health in transgender youth. However, these studies have had relatively small samples, none have been able to isolate the effects of endocrine interventions, none have included a cisgender comparison group, and none have examined the mechanisms by which endocrine interventions might improve mental health. The goal of the proposed research is twofold: (1) To examine the relationship between gender-affirming endocrine interventions and mental health in transgender youth and compare the mental health trajectories of transgender youth undergoing gender-affirming endocrine interventions to those of their cisgender peers; and (2) To explore the mechanisms underlying the relationship between endocrine interventions and mental health in transgender youth. To achieve these goals, I will measure mental health (anxiety and depression, as well as self-esteem) and body image (dissatisfaction, surveillance, depersonalization, and identity-appearance congruence) at three timepoints (before puberty suppression, after puberty suppression, and after hormone therapy) in a large sample (n=204 for puberty suppression, n=188 for hormone therapy) of transgender youth, as well as in two comparison groups (siblings, n=122, and unrelated cisgender youth, n=204). This research will allow me to determine whether endocrine interventions might help to reduce or eliminate mental health disparities between transgender and cisgender youth. I will conduct this research within the Human Diversity Lab at Princeton University, with mentorship from the lab’s PI, Dr. Kristina Olson (Sponsor), who runs the TransYouth Project, the world’s largest study of transgender youth who socially transitioned at an early age. I will also receive training from Dr. Katie McLaughlin (Collaborator), a developmental psychopathology expert at Harvard University, Dr. Robin Gomila (Consultant), a statistics expert at Princeton, and Dr. Ian Marshall (Consultant), a pediatric endocrinologist at Rutgers University. This fellowship will deepen my knowledge of developmental, clinical psychology, expand my methodological toolbox, and enable me to establish a strong publication record.

项目摘要/摘要跨性别年轻人的精神疾病水平高于其cisgender（即非转相者）同龄人。对这些精神疾病率高的贡献者提出的一个贡献者是不一致的变性年轻人一方面，他们的身体和外表之间的经验以及他们的性别认同在另一方面。医学组织建议内分泌干预措施 - 特别是青春期的抑制和马内治疗 - 可以通过停止性别发展来改善跨性别青年的心理健康 - 不一致的次要性特征和产生性别与一致的次要性别特征，然而，美国各地的立法者最近提出了禁止变性青年的法案通过获得青春期抑制和骑马疗法，断言这些干预措施不是在心理上有益。迄今为止的五项研究纵向研究了一个或这些干预措施和跨性别青年的心理健康。但是，这些研究相对小样本，没有一个能够隔离内分泌干预措施的影响，没有一个包括 Cisgender比较组，没有人检查了内分泌干预措施的机制可能会改善心理健康。拟议研究的目的是双重的：（1）检查关系在跨性别青年中对性别肯定的内分泌干预措施和心理健康之间跨性别青年的心理健康轨迹正在接受性别肯定的内分泌干预措施他们的派恩德同龄人；（2）探索内分泌之间关系的基础机制跨性别青年的干预和心理健康。为了实现这些目标，我将衡量心理健康（焦虑和抑郁，以及自尊）和身体形象（不满，监视，在三个时间点上（青春期抑制之前，之后）大量样品中的青春期抑制和激素治疗后）（青春期抑制n = 204，n = 188对于跨性别青年以及两个比较组（兄弟姐妹，n = 122且无关的）疗法） Cisgender Youth，n = 204）。这项研究将使我确定内分泌干预措施是否可能有帮助减少或消除跨性别者和赋形剂青年之间的心理健康差异。我会做这个实验室PI Kristina博士的Mentalship在普林斯顿大学人类多样性实验室的研究 Olson（赞助商），经营Transyouth Project，这是世界上最大的跨性别青年研究从小过渡。我还将获得Katie McLaughlin博士（合作者）的培训，哈佛大学的发展心理病理学专家Robin Gomila博士（顾问），统计数据普林斯顿的专家和罗格斯大学的儿科内分泌学家伊恩·马歇尔（Ian Marshall）博士（顾问）。这奖学金将加深我对发展性，临床心理学的了解，扩大我的方法论工具箱，使我能够建立强大的出版记录。