The role of night shift work in metabolic disorders during and after pregnancy
The role of night shift work in metabolic disorders during and after pregnancy
批准号:
10711699
负责人:
Isha Agarwal
金额:
$30.23万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-09-01 至 2028-08-31
关键词:
AddressAffectAgeAmericanBiochemical PathwayBiologicalBiological MarkersBiometryCenters of Research ExcellenceCesarean sectionChronic DiseaseCircadian DysregulationCircadian RhythmsCircadian desynchronyClinicalCohort StudiesComplementComplexDataDevelopmentDiabetes MellitusEatingEpidemicEpidemiologyFastingFetal MacrosomiaFundingFutureGestational AgeGestational DiabetesHairHealthHigh Risk WomanHomeostasisHydrocortisoneHyperglycemiaHypothalamic structureIL8 geneIndustryInflammationInflammatoryInsulin ResistanceInterferon Type IIInterleukin-6Intervention StudiesIntervention TrialLeadLife StyleMeasurementMeasuresMediationMentorsMesenchymalMetabolicMetabolic DiseasesMetabolic syndromeMetabolismMorbidity - disease rateMothersNon-Insulin-Dependent Diabetes MellitusNurses&apos Health StudyObesityOccupationalOutcomePhasePhysiciansPituitary GlandPlasmaPlayPregnancyPregnant WomenPrevalenceProspective StudiesProspective, cohort studyPublic HealthQuestionnairesRecording of previous eventsResearchResearch MethodologyResearch PersonnelRiskRisk FactorsRoleScientistSleepSleep disturbancesStatistical MethodsStressTNF geneTestingTrainingTraining ActivityWomanWorkawakebiological adaptation to stresscareercareer developmentcohortearly pregnancyepidemiology studyexperienceexperimental studyfollow-uphigh risklongitudinal, prospective studymetabolomicsmiddle agemodifiable riskmortalityneuroregulationpost pregnancypregnantpreventprogression riskprospectivereproductivereproductive epidemiologyrisk stratificationsecondary analysisshift worksociodemographics
中文摘要
夜班工作在怀孕期间和之后代谢紊乱中的作用
英文摘要
The role of night shift work in metabolic disorders during and after pregnancy
(I. Agarwal, Project Lead)
Gestational diabetes (GDM) is a large and growing epidemic resulting in significant morbidity and mortality to
both mothers and babies. GDM is a major risk factor for type II diabetes (T2DM), increasing the risk by 7-fold.
Factors that influence the risk of developing T2DM among women with a history of GDM are not well
understood. One emerging hypothesis is that circadian misalignment, or inappropriately timed sleep, may
influence the risk of GDM and subsequent T2DM. Night shift work, an extreme form of circadian misalignment,
has been consistently associated with a higher risk of T2DM in cross-sectional and prospective cohort studies.
Limited and conflicting data exist on the relationship of night shift work with GDM. My central hypothesis is that
night shift work increases the risk of GDM, and risk of progression from GDM to T2DM. I will test this
hypothesis using serially-collected longitudinal data from the national Nurses’ Health Study (NHS) 2 and 3
cohorts. The NHS contains detailed information on sociodemographic, clinical, reproductive, occupational, and
lifestyle variables, prospective measurement of incident clinical outcomes including T2DM over a median of 25
years of follow-up (NHS2), and hair and plasma biospecimens from a sub-cohort of pregnant women (NHS3).
Overall, the NHS is one of the most comprehensive, prospective longitudinal studies of its kind, and provides
unique opportunities to address important research questions. The aims of this project are to:
Specific Aim 1. Investigate night shift work as a modifiable risk factor for GDM, and test whether night shift
work is associated with stress-related and inflammatory biomarkers measured in early
pregnancy. If night shift work is associated with early pregnancy biomarkers, these could be
used for risk-stratification, or as sub-clinical biological endpoints in future interventional trials.
Specific Aim 2. Determine the relationship between post-pregnancy night shift work and risk of progression
from GDM to T2DM. This aim will investigate whether night shift work among high-risk women
with a history of GDM increases the risk of progression to T2DM.
The proposed research is an integral component of my career development and is tailored to complement my
training activities. It will enable me to launch a successful career as an independent researcher with expertise
in shift work and metabolism. Furthermore, it addresses an important public health issue and will inform future
research including potential interventional studies to lower rates of GDM and subsequent T2DM.
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批准号:8647621
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项目类别:
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资助金额:$3.46万
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财政年份:2014
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依托单位:
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