Experimental Models
实验模型
基本信息
- 批准号:10711560
- 负责人:
- 金额:$ 6.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-05-01 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:Animal ExperimentationAnimal ModelAwardBasic ScienceBehavior assessmentBiologicalCanis familiarisCollaborationsConsultDataDiabetes MellitusDrug Delivery SystemsElectrophysiology (science)EquipmentExperimental ModelsFacultyFamily suidaeFelis catusFosteringFundingGenotypeGlaucomaGrantHuman ResourcesIACUCMacular degenerationMethodsModificationMusOperative Surgical ProceduresOptic Nerve InjuriesOryctolagus cuniculusPostdoctoral FellowProceduresProtocols documentationPublicationsRattusReportingResearchResearch PersonnelResourcesRetinal DiseasesRodentScientistServicesSmokingTestingTissuesTrainingTranslational ResearchVisionVision researchWritingexperiencegene therapyin vivo evaluationnonhuman primatenovelnutritionresearch studyretinal ischemia
项目摘要
Experimental Models (EM) module
Summary
The purpose of the Experimental Models (EM) Module is to provide expert service and
assistance for a large variety of in vivo testing and procedures, help facilitate all experiments
using animal models performed by MVRC investigators, and to enable them to develop new
interdisciplinary projects. Specific Aims are: 1) To provide expert services and assistance,
through the use of specialized equipment and experienced personnel, for a large variety of
surgical and non-surgical procedures for experimental vision research in mice, rats, rabbits,
cats, dogs, pigs and non-human primates, 2) To provide training to all investigators on
established procedures and assist investigators developing new procedures, including new
surgical methods and drug delivery, 3) To serve as a resource center for fostering new
collaborations among MVRC scientists and clinicians, and for sharing animal models, biological
tissues and genotyping protocols, 4) To consult and assist with IACUC and IBC protocols,
including protocol writing and compliance. Experienced personnel and specialized equipment
are available in this module for vision researchers. This module is essential for numerous basic
science and translational research studies at BPEI, as indicated by its extensive use by most of
our NEI-funded investigators. In the last funding period, the EM module was used to generate
data that was reported in numerous publications and included in new grant awards.
Furthermore, this module has been essential in developing novel electrophysiological and
behavioral assessment of vision in rodents, for creating inducible animal models of glaucoma,
traumatic optic neuropathy, retinal ischemia, diabetes, and macular degeneration, testing novel
gene therapies, and investigating environmental influences on animal models of retinal disease
through the use of the rodent smoking machine and specific nutrition modifications. This module
will continue to provide an essential resource for cutting-edge research by MVRC investigators.
实验模型(EM)模块
摘要
实验模型(EM)模块的目的是提供专家服务和
协助各种体内测试和程序,帮助促进所有实验
使用MVRC研究人员进行的动物模型,并使他们能够开发出新的
跨学科项目。具体目标是:1)提供专家服务和协助,
通过使用专业的设备和经验丰富的人员,适用于种类繁多的
小鼠、大鼠、兔、小鼠和小白兔实验视力研究的手术和非手术程序,
猫、狗、猪和非人类灵长类动物,2)向所有调查人员提供关于
建立程序并协助调查人员制定新程序,包括新程序
手术方法和药物输送,3)作为培养新的
MVRC科学家和临床医生之间的合作,并分享动物模型、生物学
组织和基因分型方案,4)咨询和协助IACUC和IBC方案,
包括协议编写和合规性。经验丰富的人员和专业设备
可在本模块中为视觉研究人员提供。本模块是许多基本课程的必备模块
BPEI的科学和翻译研究,正如它被大多数
我们由NEI资助的调查人员。在上一个资助期,EM模块用于生成
在许多出版物中报道的数据,并包括在新的赠款中。
此外,该模块在开发新的电生理和
对啮齿动物的视觉进行行为学评估,以建立可诱导的青光眼动物模型,
外伤性视神经病变、视网膜缺血、糖尿病和黄斑变性,测试新书
基因治疗,以及研究环境对视网膜疾病动物模型的影响
通过使用啮齿动物吸烟机和特定的营养改良。本模块
将继续为MVRC调查人员的尖端研究提供重要资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dmitry V Ivanov其他文献
Dmitry V Ivanov的其他文献
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{{ truncateString('Dmitry V Ivanov', 18)}}的其他基金
The role of the TET-dependent DNA demethylation pathway in photoreceptor development and pathology
TET依赖性DNA去甲基化途径在光感受器发育和病理学中的作用
- 批准号:
10709133 - 财政年份:2023
- 资助金额:
$ 6.41万 - 项目类别:
Molecular mechanisms of programmed necrosis in the ischemic retina
缺血性视网膜程序性坏死的分子机制
- 批准号:
10268702 - 财政年份:2021
- 资助金额:
$ 6.41万 - 项目类别:
Molecular mechanisms of programmed necrosis in the ischemic retina
缺血性视网膜程序性坏死的分子机制
- 批准号:
10462664 - 财政年份:2021
- 资助金额:
$ 6.41万 - 项目类别:
Molecular mechanisms of programmed necrosis in the ischemic retina
缺血性视网膜程序性坏死的分子机制
- 批准号:
10672428 - 财政年份:2021
- 资助金额:
$ 6.41万 - 项目类别:
Mechanisms of toll-like receptor-mediated neurotoxicity in the ischemic retina
Toll样受体介导的缺血性视网膜神经毒性机制
- 批准号:
9207596 - 财政年份:2017
- 资助金额:
$ 6.41万 - 项目类别:
Role of toll-like receptor signaling in retinal ischemia
Toll样受体信号传导在视网膜缺血中的作用
- 批准号:
8448079 - 财政年份:2012
- 资助金额:
$ 6.41万 - 项目类别:
Role of toll-like receptor signaling in retinal ischemia
Toll样受体信号传导在视网膜缺血中的作用
- 批准号:
8272305 - 财政年份:2012
- 资助金额:
$ 6.41万 - 项目类别:
Role of toll-like receptor signaling in retinal ischemia
Toll样受体信号传导在视网膜缺血中的作用
- 批准号:
8634102 - 财政年份:2012
- 资助金额:
$ 6.41万 - 项目类别:
The role of cell death signals in retinal ischemia
细胞死亡信号在视网膜缺血中的作用
- 批准号:
7872225 - 财政年份:2010
- 资助金额:
$ 6.41万 - 项目类别:
The role of cell death signals in retinal ischemia
细胞死亡信号在视网膜缺血中的作用
- 批准号:
8035310 - 财政年份:2010
- 资助金额:
$ 6.41万 - 项目类别:
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