Experimental Models

实验模型(EM)模块 摘要 实验模型(EM)模块的目的是提供专家服务和 协助各种体内测试和程序，帮助促进所有实验 使用MVRC研究人员进行的动物模型，并使他们能够开发出新的 跨学科项目。具体目标是：1)提供专家服务和协助， 通过使用专业的设备和经验丰富的人员，适用于种类繁多的 小鼠、大鼠、兔、小鼠和小白兔实验视力研究的手术和非手术程序， 猫、狗、猪和非人类灵长类动物，2)向所有调查人员提供关于 建立程序并协助调查人员制定新程序，包括新程序 手术方法和药物输送，3)作为培养新的 MVRC科学家和临床医生之间的合作，并分享动物模型、生物学 组织和基因分型方案，4)咨询和协助IACUC和IBC方案， 包括协议编写和合规性。经验丰富的人员和专业设备 可在本模块中为视觉研究人员提供。本模块是许多基本课程的必备模块 BPEI的科学和翻译研究，正如它被大多数 我们由NEI资助的调查人员。在上一个资助期，EM模块用于生成 在许多出版物中报道的数据，并包括在新的赠款中。 此外，该模块在开发新的电生理和 对啮齿动物的视觉进行行为学评估，以建立可诱导的青光眼动物模型， 外伤性视神经病变、视网膜缺血、糖尿病和黄斑变性，测试新书 基因治疗，以及研究环境对视网膜疾病动物模型的影响 通过使用啮齿动物吸烟机和特定的营养改良。本模块 将继续为MVRC调查人员的尖端研究提供重要资源。

Experimental Models (EM) module Summary The purpose of the Experimental Models (EM) Module is to provide expert service and assistance for a large variety of in vivo testing and procedures, help facilitate all experiments using animal models performed by MVRC investigators, and to enable them to develop new interdisciplinary projects. Specific Aims are: 1) To provide expert services and assistance, through the use of specialized equipment and experienced personnel, for a large variety of surgical and non-surgical procedures for experimental vision research in mice, rats, rabbits, cats, dogs, pigs and non-human primates, 2) To provide training to all investigators on established procedures and assist investigators developing new procedures, including new surgical methods and drug delivery, 3) To serve as a resource center for fostering new collaborations among MVRC scientists and clinicians, and for sharing animal models, biological tissues and genotyping protocols, 4) To consult and assist with IACUC and IBC protocols, including protocol writing and compliance. Experienced personnel and specialized equipment are available in this module for vision researchers. This module is essential for numerous basic science and translational research studies at BPEI, as indicated by its extensive use by most of our NEI-funded investigators. In the last funding period, the EM module was used to generate data that was reported in numerous publications and included in new grant awards. Furthermore, this module has been essential in developing novel electrophysiological and behavioral assessment of vision in rodents, for creating inducible animal models of glaucoma, traumatic optic neuropathy, retinal ischemia, diabetes, and macular degeneration, testing novel gene therapies, and investigating environmental influences on animal models of retinal disease through the use of the rodent smoking machine and specific nutrition modifications. This module will continue to provide an essential resource for cutting-edge research by MVRC investigators.