Racial Differences in Geriatric Antidepressant Adherence

描述（由申请人提供）：老年抑郁症通常是慢性或复发性的，并与大量的痛苦，残疾，自杀风险和健康相关的生活质量下降。虽然抗抑郁药和心理治疗显然是有效的，但老年患者往往没有按照处方或建议服用，多达40%的患者过早停止用药。即使有成功的卫生系统的变化，如初级保健的合作护理模式，治疗差距仍然存在，因此，治疗依从性差可能会限制许多老年患者实现这些有效治疗的好处的程度。虽然抑郁症的临床诊断率存在种族差异，但对抑郁症治疗依从率或老年患者依从性的关键决定因素的种族差异知之甚少。来自混合年龄样本的有限数据表明，非洲裔美国患者可能比白色患者更不愿意接受心理治疗或抗抑郁治疗。本研究将使用混合方法，以确定老年非裔美国人和白色患者中抑郁症治疗依从性的关键可改变的决定因素。一项包括定量和定性组成部分的基线调查将评估可能决定遵守情况的关键结构，特别注意各种族群体之间可能存在差异的可能因素（精神和耻辱）。此外，由一组患者（每组n=6-8）组成的四个焦点小组将使我们能够获得更深入的定性信息，并为后续调查增加新的领域提供信息。在5个参与的初级保健诊所中心最近诊断为具有临床意义的抑郁症的60岁或以上的非洲裔美国人（n= 103）和白色（n=103）患者将有资格参加。使用基线和4个月的随访调查，我们将比较非裔美国人和白色患者之间的依从性，并确定与新诊断的抑郁症急性期不依从性最显著相关的决定因素。通过确定非裔美国人和白色老年人中抑郁症治疗依从性的关键可改变决定因素，临床医生和研究人员将更有效地识别高危人群，并制定量身定制的干预措施，可能会改善他们的治疗依从性和抑郁症的结果。

DESCRIPTION (provided by applicant): Geriatric depression is often chronic or recurrent, and is associated with substantial suffering, disability, suicide risk and decreased health-related quality of life. Although antidepressants and psychotherapy are clearly effective, older patients often fail to take them as prescribed or recommended and as many as 40% discontinues medication use prematurely. Even with successful health system changes such as collaborative care models in primary care, treatment gaps remain, and thus, poor treatment adherence may limit the extent to which many geriatric patients realize the benefits of these efficacious treatments. While there are racial differences in clinical diagnostic rates of depression, substantially less is known about racial differences in depression treatment adherence rates or the key determinants of adherence among older patients. Limited data from mixed-age samples suggests that African-American patients may be even less willing to engage in psychotherapy or accept antidepressant treatment than white patients. This study will use a mixed methods approach in order to identify the key modifiable determinants of depression treatment adherence among older African-American and white patients. A baseline survey including both quantitative and qualitative components will assess key constructs potentially determining adherence, with particular attention to possible factors (spirituality and stigma) that may differ across racial groups. In addition, four focus groups held with a subset of patients (n=6-8 for each group) will allow us to obtain more in-depth qualitative information and inform the addition of new domains to the follow-up survey. African-American (n=103) and white (n=103) patients 60 years old or over with the recent diagnosis of clinically significant depression in five participating primary care clinic sites will be eligible. Using the baseline and a four-month follow-up survey, we will compare rates of adherence between African-American and white patients and identify the determinants most significantly associated with non-adherence in the acute phase following a new diagnosis of depression. By identifying the key modifiable determinants of depression treatment adherence among both African-American and white elders, clinicians and researchers will be much more effective in identifying at-risk individuals and developing tailored interventions that may improve their treatment adherence and depression outcomes.