NICHD SERVICES: MPT DATABASE ACCESS AND MAINTENANCE

倡议的科学依据： 与美国国际开发署签署支持 CAMI Health 扩大非激素 MPT 领域的机构间协议 (Y01) - 请注意：CAMI 是 名称，而不是缩写或首字母缩略词。 NICHD 尚未召开 2020 财年艾滋病毒/艾滋病规划会议，因此稍后可能需要更改这一理由。 多用途技术有潜力保护妇女和女童免受相互关联的性健康和生殖健康风险。该倡议 多用途预防技术 (IMPT) 是 CAMI-health 的一个项目，CAMI-health 是一个致力于改善妇女健康的组织 和世界各地的女孩，居住在公共卫生研究所 (PHI)。 过去，CRB 资助 CAMI-health，让 IMPT 协调 MPT 领域，主要是在激素类产品的方向上， 因此，该领域一直集中在该领域。 近两年来，避孕研究分会和妇幼保健院 儿科传染病科已开始合作，目标是开发具有避孕作用的非激素 MPT 和艾滋病毒预防特性。 这代表了过去十年研究的范式转变，过去十年的研究主要集中在 基于激素的 MPT 的开发。该举措旨在利用 IMPT 的丰富经验、技能和资源来推动 开发非激素 MPT 并协助吸引该领域的研究人员，建立积极和有影响力的会议和电话会议 感兴趣的研究人员，促进全球研究参与/伙伴关系，并提高行业在非激素领域的参与 MPT。 倡议背景： 多用途技术 (MPT) 是将避孕与艾滋病毒预防相结合的一种非常有前途的方法，并提供了一种 有吸引力的公共卫生方法。 近年来，CAMI-health 的 IMPT 在协调多用途方面发挥了重要作用。 技术领域，主要重点是推动基于激素的 MPT 的发展。请求继续为本次 IAA 提供资金 允许 CRB 和 MPIDB 利用与 CAMI-health 的关系来增加 IMPT 的活动： 开发不基于激素作用的新颖、创新的 MPT。 去年，CRB已经开始了该领域的资助工作，MPIDB也将在不久的将来进行资助。 面积具有重大意义 两个分支的利息。 该倡议的目标是什么？ 该倡议的目标是让 IMPT 利用其在该领域的专业知识和知识来提高认识并激励更多的全球 非激素 MPT 发展的活动。 这包括但不限于提高研究人员、全球 资助机构和行业。 2020 财年艾滋病 IC 申请 NICHD （单位：千美元） 倡议理由 第 18 页，共 19 页 打印时间：下午 4:43 打印日期：2018 年 7 月 5 日 · 每年组织和举办 1-2 场技术网络研讨会，主题是模拟与技术相关的障碍和机遇的讨论 非激素 MPT 的发展。示例包括： 岛 非激素 MPT 的开发； 二. 跨技术平台合作，以综合方式应对挑战。 · 制定、修订并向利益相关者传播非激素 MPT 相关宣传材料。 通过与避孕研究处、妇产科和妇产科的讨论，可以改进工作，并增加新的活动。 儿科传染病分会和多用途预防技术倡议。 将每季度审查进展情况，并根据为实现协议目标而开展的有意义的活动来衡量进展情况。 在 在接下来的几个月中，特拉维斯·肯特 (Travis Kent) 博士将作为美国科学促进会 (AAAS) 研究员与 CRB 建立联系，预计他将成为关键人物 参与这些活动。

Scientific Justification of Initiative: Interagency Agreement with USAID to Support CAMI Health to Expand the Field of Nonhormonal MPTs (Y01) - please note: CAMI is a name, not an abbreviation or acronym. NICHD has not yet had its FY2020 HIV/AIDS planning session so changes to this justification may be needed later. Multi-Purpose Technologies have the potential to protect women and girls from interlinked sexual and reproductive health risks. The Initiative for Multipurpose Prevention Technologies (IMPT) is a project of CAMI-health, an organization dedicated to improving the health of women and girls worldwide, housed at the Public Health Institute (PHI). In the past the CRB funded CAMI-health to have the IMPT coordinate the MPT field, primarily in the direction of hormonally based products, and as a result the field has been focused in that area. In the past two years, the Contraception Research Branch and the Maternal and Pediatric Infectious Disease Branch have begun collaborating with the goal of developing nonhormonal MPTs that have both contraceptive and HIV-prevention properties. This represents a paradigm shift away from research of the past decade which has focused primarily on the development of hormonally based MPTs. This initiative seeks to employ IMPT's significant experience, skill and resources to advance the development of nonhormonal MPTs and assist in attracting researchers from the field, establish meetings and teleconferences of active and interested researchers, facilitate global research engagement/partnership and improve industry engagement in the area of nonhormonal MPTs. Initiative Background: Multipurpose Technologies (MPTs) represent a very promising approach for combining contraception with HIV prevention and provide an attractive public health approach. In recent years the IMPT of CAMI-health has been a strong presence in coordinating the multipurpose technology field, with the primary focus of driving the development of hormone based MPTs. This request to continue funding of this IAA allows the CRB and the MPIDB to leverage the relationship with CAMI-health to increase the activity of the IMPT in the direction of developing novel, innovative MPTs that are not based on hormonal action. In last year, the CRB has begun funding work in this area and the MPIDB will make awards in the near future. The area is of significant interest to both branches. What are the goals of this initiative? The goals of this initiative are for IMPT to use its expertise and knowledge of the field to increase awareness and stimulate more global activity on nonhormonal MPT development. This includes but is not limited to increasing awareness on the part of researchers, global funding agencies and industry. FY 2020 AIDS IC Request NICHD (Dollars in Thousands) Initiative Justification Page 18 of 19 Print Time: 4:43 PM Print Date: 7/5/2018 · Organize and host 1-2 technical webinars annually on topics to simulate discussion of barriers and opportunities related to the development of nonhormonal MPTs. Examples include: i. development of nonhormonal MPTs; ii. working across technology platforms to approach challenges in an integrated manner. · Develop, revise, and disseminate nonhormonal MPT-related outreach materials to stakeholders. The work may be refined, and new activities may be added through discussions with the Contraception Research Branch, the Maternal and Pediatric Infectious Disease Branch and the Initiative for Multipurpose Prevention Technologies. Progress will be reviewed quarterly and measured based on the conduct of meaningful activities to fulfill the objectives of the agreement. In the coming months, Dr. Travis Kent will become associated with the CRB as an AAAS Fellow, and it is expected that he will become a key participant in these activities.