NICHD SERVICES: MPT DATABASE ACCESS AND MAINTENANCE

倡议的科学依据： 与美国国际开发署达成的机构间协议，支持CAMI卫生部扩大非激素MPT领域（Y01）-请注意：CAMI是一个 名称，而不是缩写或首字母缩略词。 NICHD尚未举行2020财年艾滋病毒/艾滋病规划会议，因此稍后可能需要对此理由进行修改。 多用途技术有可能保护妇女和女孩免受相互关联的性健康和生殖健康风险。主动 多用途预防技术（IMPT）是CAMI健康组织的一个项目，该组织致力于改善妇女健康 世界各地的妇女和女孩，住在公共卫生研究所（PHI）。 在过去，CRB资助CAMI健康，让IMPT协调MPT领域，主要是在基于药物的产品方向， 因此，该领域一直专注于该领域。 在过去两年中，避孕研究分支和产妇和 儿科传染病分支已经开始合作，目标是开发非激素型MPTs， 和预防艾滋病的特性。 这代表了过去十年研究范式的转变，过去十年的研究主要集中在 开发基于MPT的产品。这一举措旨在利用IMPT的丰富经验、技能和资源， 开发非激素MPT，并协助吸引该领域的研究人员，建立积极和 感兴趣的研究人员，促进全球研究参与/伙伴关系，并改善非激素领域的行业参与 MPTs 倡议背景： 多用途技术（MPT）是一种非常有前途的方法，可以将避孕与艾滋病毒预防相结合， 有吸引力的公共卫生方法。 近年来，非洲工业部长会议-卫生部的综合方案小组在协调多用途 技术领域，主要重点是推动基于激素的MPT的发展。关于继续为执行援助提供资金的请求 允许CRB和MPIDB利用与CAMI-健康的关系，以增加IMPT的活动， 开发新的，创新的MPT，不基于激素的作用。 去年，CRB已开始资助这一领域的工作，MPIDB将在不久的将来颁发奖项。 该地区具有重要意义 两个部门的兴趣。 这一倡议的目标是什么？ 这一倡议的目标是使IMPT利用其在该领域的专长和知识，提高认识，促进更多的全球性合作。 对非激素MPT发育的活性。 这包括但不限于提高研究人员的认识， 资助机构和行业。 2020财年艾滋病IC申请 NICHD （千美元） 第18页，共19页打印时间：下午4：43 打印日期：2018年7月5日 · 每年组织和主办1 - 2次技术网络研讨会，主题是模拟讨论与 非激素MPTs的发展。示例包括： I. 非激素MPTs的发展; 二. 跨技术平台工作，以综合方式应对挑战。· 制定，修订，并传播非激素MPT相关的宣传材料，以利益相关者。 通过与避孕研究分支、产妇和新生儿保健处和卫生部的讨论，这项工作可能会得到改进，并可能会增加新的活动。 儿科传染病分支和多用途预防技术倡议。 每季度将对进展情况进行审查，并根据为实现协议目标而开展的有意义的活动进行衡量。 在 在接下来的几个月里，特拉维斯肯特博士将成为CRB的AAAS研究员，预计他将成为一个关键 参加这些活动。

Scientific Justification of Initiative: Interagency Agreement with USAID to Support CAMI Health to Expand the Field of Nonhormonal MPTs (Y01) - please note: CAMI is a name, not an abbreviation or acronym. NICHD has not yet had its FY2020 HIV/AIDS planning session so changes to this justification may be needed later. Multi-Purpose Technologies have the potential to protect women and girls from interlinked sexual and reproductive health risks. The Initiative for Multipurpose Prevention Technologies (IMPT) is a project of CAMI-health, an organization dedicated to improving the health of women and girls worldwide, housed at the Public Health Institute (PHI). In the past the CRB funded CAMI-health to have the IMPT coordinate the MPT field, primarily in the direction of hormonally based products, and as a result the field has been focused in that area. In the past two years, the Contraception Research Branch and the Maternal and Pediatric Infectious Disease Branch have begun collaborating with the goal of developing nonhormonal MPTs that have both contraceptive and HIV-prevention properties. This represents a paradigm shift away from research of the past decade which has focused primarily on the development of hormonally based MPTs. This initiative seeks to employ IMPT's significant experience, skill and resources to advance the development of nonhormonal MPTs and assist in attracting researchers from the field, establish meetings and teleconferences of active and interested researchers, facilitate global research engagement/partnership and improve industry engagement in the area of nonhormonal MPTs. Initiative Background: Multipurpose Technologies (MPTs) represent a very promising approach for combining contraception with HIV prevention and provide an attractive public health approach. In recent years the IMPT of CAMI-health has been a strong presence in coordinating the multipurpose technology field, with the primary focus of driving the development of hormone based MPTs. This request to continue funding of this IAA allows the CRB and the MPIDB to leverage the relationship with CAMI-health to increase the activity of the IMPT in the direction of developing novel, innovative MPTs that are not based on hormonal action. In last year, the CRB has begun funding work in this area and the MPIDB will make awards in the near future. The area is of significant interest to both branches. What are the goals of this initiative? The goals of this initiative are for IMPT to use its expertise and knowledge of the field to increase awareness and stimulate more global activity on nonhormonal MPT development. This includes but is not limited to increasing awareness on the part of researchers, global funding agencies and industry. FY 2020 AIDS IC Request NICHD (Dollars in Thousands) Initiative Justification Page 18 of 19 Print Time: 4:43 PM Print Date: 7/5/2018 · Organize and host 1-2 technical webinars annually on topics to simulate discussion of barriers and opportunities related to the development of nonhormonal MPTs. Examples include: i. development of nonhormonal MPTs; ii. working across technology platforms to approach challenges in an integrated manner. · Develop, revise, and disseminate nonhormonal MPT-related outreach materials to stakeholders. The work may be refined, and new activities may be added through discussions with the Contraception Research Branch, the Maternal and Pediatric Infectious Disease Branch and the Initiative for Multipurpose Prevention Technologies. Progress will be reviewed quarterly and measured based on the conduct of meaningful activities to fulfill the objectives of the agreement. In the coming months, Dr. Travis Kent will become associated with the CRB as an AAAS Fellow, and it is expected that he will become a key participant in these activities.