THE CONTINUUM OF CARE IN HOSPITALIZED PATIENTS WITH OPIOID USE DISORDER AND INFECTIOUS COMPLICATIONS OF DRUG USE (CHOICE)

患有阿片类药物使用障碍和药物使用感染并发症的住院患者的连续护理（选择）

• 批准号: 10717509
• 负责人: MATTHEW KIRKBY
• 金额: $ 233万
• 依托单位: PPD DEVELOPMENT LP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10717509
• 关键词: Academic Medical Centers; Address; Aftercare; Alabama; Bacterial Infections; Baltimore; Caring; Communicable Diseases; Complication; Consult; Continuity of Patient Care; District of Columbia; Drug usage; Effectiveness of Interventions; Epidemic; Goals; HIV; Healthcare; Helping to End Addiction Long-term; Hepatitis C virus; Hospitalization; Hospitals; Individual; Infection; Infective endocarditis; Inpatients; Intervention; Investigation; Location; Maryland; Medicaid; Medical; Medical center; Modeling; Opiate Addiction; Opioid; Outcome; Outpatients; Patients; Pharmaceutical Preparations; Public Health; Research; Rural Population; Speed; System; Time; United States; United States National Institutes of Health; Universities; University Hospitals; Washington; addiction; high risk; improved; improved outcome; multidisciplinary; opioid epidemic; opioid misuse; opioid use disorder; prevent; uptake

In the United States, there is an opioid epidemic which is associated with acquisition of HIV, HCV and STIs, as well as rising rates of infective endocarditis and systemic bacterial infections.(1-3) Given the clear intersection of these parallel epidemics of infectious diseases and opioid use disorder, it is critical that we identify models of care which prevent acquisition of these infections and enhance treatment of existing infections by addressing opioid use disorder throughout the continuum of care.(4,5) Many individuals with opioid use disorder (OUD) are not engaged in medical care, therefore, inpatient hospitalization represents an opportune time to initiate treatment and engagement among these high risk individuals. However, inpatient interventions to address addiction are often suboptimal, incomplete, or limited to the time of hospitalization.(6) Further, observational investigations in individual hospital systems have demonstrated the effectiveness of interventions, including addiction consult teams, multidisciplinary rounds, and linkage navigators, in increasing uptake of medications for opioid use disorder during hospitalization and linkage into addictions treatment after discharge. However, there have been no multi-center investigations to rigorously evaluate the impact of these interventions on long term infectious outcomes. This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction

在美国，阿片类药物流行与 HIV、HCV 和 STI 的感染以及感染性心内膜炎和全身性细菌感染的发病率上升有关。(1-3) 鉴于这些平行流行的传染病和阿片类药物使用障碍之间存在明显的交叉点，我们必须确定能够预防这些感染的感染并通过以下方式加强对现有感染的治疗的护理模式： 在整个护理过程中解决阿片类药物使用障碍问题。(4,5) 许多阿片类药物使用障碍 (OUD) 患者没有接受医疗护理，因此，住院治疗是在这些高危人群中开始治疗和参与的最佳时机。然而，解决成瘾问题的住院干预措施往往不是最理想的、不完整的，或者仅限于住院期间。(6) 此外，各个医院系统的观察性调查已经证明了干预措施的有效性，包括成瘾咨询小组、多学科查房和联动导航器，可增加住院期间阿片类药物使用障碍药物的吸收，并与出院后的成瘾治疗联系起来。然而，还没有进行多中心调查来严格评估这些干预措施对长期感染结果的影响。 这项研究是 NIH 帮助消除成瘾长期 (HEAL) 计划的一部分，该计划旨在加快科学解决国家阿片类药物公共卫生危机的速度。 NIH HEAL Initiative 支持 NIH 的研究，以改善阿片类药物滥用和成瘾的治疗