Proteomic biomarkers for radiation injury and countermeasure efficacy

放射损伤的蛋白质组生物标志物及对策效果

• 批准号: 10723267
• 负责人: Vijay Singh
• 金额: $ 10万
• 依托单位: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723267
• 关键词: Animals; Biological; Biological Markers; Data; Development; Dose; Experimental Models; Exposure to; Gamma Rays; Individual; Interleukin-11; Molecular Target; Prediction of Response to Therapy; Proteomics; Radiation Injuries; Research Project Grants; Sampling; Subcutaneous Injections; Treatment outcome; analog; irradiation; nonhuman primate; pre-clinical; radiation countermeasure; radiation mitigator

The overall objective of this research project is to determine proteomic biomarkers of irradiation in preclinical experimental models of non-human primates (NHP). These data may permit prediction of treatment outcomes for individuals exposed to γ-radiation over the long term. Additionally, such biomarkers may help identify molecular targets useful for the development of promising radiomitigators.

本研究项目的总体目标是确定非人灵长类动物（NHP）临床前实验模型中辐射的蛋白质组学生物标志物。这些数据可能有助于预测长期暴露于γ辐射的个人的治疗结果。此外，这些生物标志物可能有助于识别分子靶点，用于开发有前途的放射性抑制剂。