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Understanding inter-organellar communication in apicomplexan parasites

Understanding inter-organellar communication in apicomplexan parasites
了解顶复门寄生虫的细胞器间通讯
批准号:
10714402
负责人:
Diego Huet
金额:
$37.75万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-09-22 至 2028-07-31

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中文摘要
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英文摘要
PROJECT SUMMARY/ABSTRACT Inter-organellar communication is an essential process for cellular function. Inside the cell, organelles can interact through specialized microdomains called membrane contact sites (MCSs). These structures mediate the close apposition of two organellar membranes, allowing the exchange of metabolites. In doing so, MCSs are crucial for cellular homeostasis and metabolic plasticity. However, most of what is known about MCSs comes only from a handful of well-studied metazoans, particularly yeast and mammals. Studying the function and composition of MCSs in other eukaryotes—particularly in divergent lineages possessing phylum-specific organelles—is therefore crucial to gain insights into the mechanisms requiring an independent solution to inter- organellar communication. My group seeks to understand inter-organellar communication in apicomplexans, are a group of parasitic protists that include the causative agents of malaria and toxoplasmosis. In their complex life cycles, many of these organisms transition through a variety of environments as they enter and exit cells in different host species. The ability to propagate within a wide range of cell types relies on the capacity to access nutrients from diverse and changing environments, which underscores the metabolic plasticity of apicomplexans. Most apicomplexans possess a single mitochondrion and an apicoplast, a non-photosynthetic plastid that arose from a secondary endosymbiotic event at least 600 million years ago. Both organelles have been coevolving ever since, and now play crucial roles in the metabolic plasticity and survival of these parasites. Although a close physical interaction between the mitochondrion and the apicoplast has been observed, the molecular identity of this interaction remains elusive. Using the model apicomplexan Toxoplasma gondii, my laboratory aims to identify the molecular effectors mediating the mitochondrion-apicoplast interaction using two different, yet complementary approaches: proximity biotinylation and bimolecular complementation. As the apicoplast is an apicomplexan-specific organelle, the identification of proteins involved in mitochondrion-apicoplast MCSs could provide opportunities for the design of anti-parasitic therapies against these pathogens. Our work will open new scientific venues of apicomplexan biology, and yield insight into the evolution and organellar crosstalk in these organisms.
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Understanding the highly divergent mitochondrial ATP synthase in T. gondii
  • 批准号:
    10056323
  • 项目类别:
  • 资助金额:
    $24.9万
  • 财政年份:
    2020
  • 负责人:
    Diego Huet
  • 依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
  • 批准号:
    31024801
  • 项目类别:
    专项基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2010
  • 负责人:
    贺萍
  • 依托单位: