Core C: Biostatistics

核心 C：生物统计学

• 批准号: 10715767
• 负责人: Summer S Han
• 金额: $ 13.24万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10715767
• 关键词: Address; Administrative Personnel; Advanced Development; Basic Science; Bioinformatics; Biological; Biometry; Biostatistics Core; Cells; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Communities; Computing Methodologies; Data; Data Analyses; Data Collection; Data Scientist; Data Set; Development; Elements; Ensure; Environment; Epidemiologist; Equity; Experimental Designs; Formulation; Genetic; Genomics; Genotype; Goals; Grant; Housing; Image; Infrastructure; Institution; Intervention; Laboratory Study; Maintenance; Methods; Mission; Molecular; Observational Study; Output; Pathway interactions; Patient Monitoring; Phenotype; Play; Policies; Positioning Attribute; Procedures; Program Research Project Grants; Publications; Randomized; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sample Size; Science; Secure; Services; Specialist; Statistical Data Interpretation; Statistical Methods; Structure; Supervision; Talents; Technology; Translational Research; United States National Institutes of Health; Universities; biomedical data science; biomedical informatics; cancer genomics; cellular imaging; data harmonization; data management; data repository; data standards; design; experience; experimental study; follow-up; genomic data; human data; human subject; human tissue; innovation; interdisciplinary approach; malignant stomach neoplasm; medical schools; meetings; member; mid-career faculty; next generation sequencing; novel; open source; pre-clinical; prevent; risk stratification; single cell analysis; web-based tool

ABSTRACT – BIOSTATISTICS CORE C The goal of the Biostatistics Core is to provide support for the statistical analysis generated from three projects. These supportive functions include the implementation of the study design and data analysis, the development and applications of innovative statistical methods for single cell genomics and the timely dissemination of findings as related to publications and research meetings. In summary this support consists of the following: (1) Provide expert and timely consultative services to Project investigators throughout the course of research. (2) Organize clinical data generated from the PPG. (3) Develop statistical methods suitable for single cell analysis. (4) Aid in reporting results with the Project teams. The core team consists of biostatisticians, data management specialists, data scientists, epidemiologists, and administrative personnel. The Biostatistics Core team will communicate regularly and in a structured format with project investigators to ensure the appropriate design, analysis and interpretation of preclinical and clinical experiments of the PPG. The Biostatistics Core has experience and expertise across the breadth of biostatistics including within the domains of computational genetic data set analysis, analysis of biological pathways, clinical trial design and analysis, and observational study design and analysis. This support will include the planning of new studies with regards to experimental design, estimation of sample size and power calculations, and methods for randomization when appropriate. The Biostatistics Core will collaborate with the PPG investigators in all stages of research, from the formulation of the research questions through study design, data management, and data analyses for laboratory studies (Projects 1-2), studies involving human tissues, observational and clinical trial studies (Project 3), and principal interpretation for dissemination. The Biostatistics Core will closely coordinate with the Administrative Core A and the Cellular, Genomics and Imaging Core B to ensure timely completion of research objectives, efficient use of shared resources, effective dissemination of research findings, and compliance with regulatory policy and reporting requirements.

摘要-生物统计学核心C 生物统计核心的目标是为三个项目产生的统计分析提供支持。 这些支持性功能包括研究设计和数据分析的实施， 单细胞基因组学创新统计方法的应用和研究结果的及时传播 与出版物和研究会议有关。总之，这种支持包括以下内容： (1)在整个过程中为项目调查人员提供专家和及时的咨询服务 research. (2)组织PPG生成的临床数据。 (3)开发适用于单细胞分析的统计方法。 (4)协助项目团队报告结果。 核心团队由生物统计学家、数据管理专家、数据科学家、流行病学家和 行政人员。生物统计学核心团队将定期以结构化格式与 项目研究者，以确保适当的设计，分析和解释临床前和临床 PPG的实验生物统计学核心在生物统计学领域拥有丰富的经验和专业知识 包括在计算遗传数据集分析、生物学途径分析、临床 试验设计和分析以及观察性研究设计和分析。这种支持将包括规划 关于实验设计、样本量估计和功效计算以及方法的新研究 在适当的时候进行随机化。生物统计学核心将与PPG研究者合作， 研究阶段，从研究问题的制定到研究设计，数据管理， 实验室研究（项目1-2）、涉及人体组织的研究、观察性和临床研究的数据分析 试验研究（项目3）和传播的主要解释。生物统计学核心将密切 与行政核心A和细胞、基因组学和成像核心B协调，以确保及时 完成研究目标，有效利用共享资源，有效传播研究成果， 以及遵守监管政策和报告要求。