Core C: Biostatistics

摘要-生物统计学核心C 生物统计核心的目标是为三个项目产生的统计分析提供支助。 这些支持功能包括实施研究设计和数据分析、开发 以及单细胞基因组学创新统计方法的应用和研究结果的及时传播 与出版物和研究会议有关。总而言之，这一支持包括以下内容： (1)全程为项目调查人员提供专业、及时的咨询服务 研究。 (2)组织PPG产生的临床数据。 (3)发展适合于单细胞分析的统计方法。 (4)协助项目团队报告结果。 核心团队由生物统计学家、数据管理专家、数据科学家、流行病学家和 行政人员。生物统计核心团队将定期以结构化的形式与 项目调查员确保临床前和临床的适当设计、分析和解释 PPG的实验研究。生物统计学核心在生物统计学领域拥有丰富的经验和专业知识 包括在计算遗传数据集分析、生物路径分析、临床 试验设计与分析，观察性研究设计与分析。这项支持将包括规划 关于实验设计、样本量估计和功率计算以及方法的新研究 在适当的时候进行随机化。生物统计核心将在所有方面与PPG调查人员合作 研究阶段，从研究问题的形成到研究设计、数据管理和 实验室研究(项目1-2)、人体组织研究、观察性研究和临床研究的数据分析 试行研究(项目3)，以及传播的主要解释。生物统计核心将密切关注 与行政核心A和细胞、基因组和成像核心B协调，确保及时 完成研究目标，有效利用共享资源，有效传播研究成果， 以及遵守监管政策和报告要求。

ABSTRACT – BIOSTATISTICS CORE C The goal of the Biostatistics Core is to provide support for the statistical analysis generated from three projects. These supportive functions include the implementation of the study design and data analysis, the development and applications of innovative statistical methods for single cell genomics and the timely dissemination of findings as related to publications and research meetings. In summary this support consists of the following: (1) Provide expert and timely consultative services to Project investigators throughout the course of research. (2) Organize clinical data generated from the PPG. (3) Develop statistical methods suitable for single cell analysis. (4) Aid in reporting results with the Project teams. The core team consists of biostatisticians, data management specialists, data scientists, epidemiologists, and administrative personnel. The Biostatistics Core team will communicate regularly and in a structured format with project investigators to ensure the appropriate design, analysis and interpretation of preclinical and clinical experiments of the PPG. The Biostatistics Core has experience and expertise across the breadth of biostatistics including within the domains of computational genetic data set analysis, analysis of biological pathways, clinical trial design and analysis, and observational study design and analysis. This support will include the planning of new studies with regards to experimental design, estimation of sample size and power calculations, and methods for randomization when appropriate. The Biostatistics Core will collaborate with the PPG investigators in all stages of research, from the formulation of the research questions through study design, data management, and data analyses for laboratory studies (Projects 1-2), studies involving human tissues, observational and clinical trial studies (Project 3), and principal interpretation for dissemination. The Biostatistics Core will closely coordinate with the Administrative Core A and the Cellular, Genomics and Imaging Core B to ensure timely completion of research objectives, efficient use of shared resources, effective dissemination of research findings, and compliance with regulatory policy and reporting requirements.