Hawaii Minority Health and Cancer Disparities SPORE

夏威夷少数民族健康与癌症差异 SPORE

• 批准号: 10716152
• 负责人: Jeffrey Lee Berenberg
• 金额: $ 167.32万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10716152
• 关键词: Address; Adenocarcinoma; Adherence; Asian Americans; Behavioral; Bioinformatics; Biological; Biological Markers; Biometry; Blood specimen; Breast; Breast Cancer Risk Factor; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Prognosis; Catchment Area; Cells; Center for Translational Science Activities; Central obesity; Characteristics; Clinical; Clinical Management; Collaborations; Communities; Community Clinical Oncology Program; DNA Methylation; Data Analyses; Data Science; Development; Dietary Practices; Disease; Economics; Environment; Ethnic Population; Etiology; Evaluation; Fatty acid glycerol esters; Freezing; Funding; Future; Goals; Grant; Hawaii; Image; Individual; Infrastructure; Institution; Intervention; Intervention Studies; Leukocytes; Liver; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Mammary Neoplasms; Measures; Methylation; Minority; Minority Groups; Minority Health Research; Molecular; Mutation; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Not Hispanic or Latino; Obesity; Outcome; Pacific Islands; Pathology; Patients; Performance; Phase; Pilot Projects; Population; Population Group; Population Heterogeneity; Prevention; Primary carcinoma of the liver cells; Randomized; Research; Research Infrastructure; Research Personnel; Rest; Risk; Small Cell Carcinoma; Smoker; Specialized Program of Research Excellence; Squamous Cell; Strategic Planning; Testing; Therapeutic; Translating; Translational Research; Translations; Tumor Biology; Universities; Visceral; Vulnerable Populations; biobank; cancer health disparity; cancer risk; career; chronic liver disease; community based participatory research; community center; data management; efficacy testing; elastography; ethnic difference; ethnic disparity; experience; follow-up; health care quality; health disparity; health equity; improved; innovation; lifestyle intervention; lung cancer screening; malignant breast neoplasm; minority health disparity; multi-ethnic; multidisciplinary; non-alcoholic fatty liver; non-alcoholic fatty liver disease; outreach; phase III trial; pilot trial; prediction algorithm; prognostic significance; programs; racial difference; racial disparity; radiomics; randomized trial; recruit; risk prediction model; screening; screening guidelines; secondary endpoint; social culture; tool; transcriptomics; translational study; tumor; tumor microenvironment; underserved minority; uptake

Project Summary/Abstract At the root of health disparities is the diversity that exists in the biological, behavioral, sociocultural, and environmental characteristics of individuals and populations. Hawai`i offers exceptional opportunities for minority health research due to its uniquely diverse population with varying cancer burdens and its high-quality health care and cancer registration. The University of Hawai`i Cancer Center has a successful track record of leveraging Hawai`i's multiethnic population to study racial/ethnic differences in cancer risk and outcomes. It has built a community-facing infrastructure to translate these findings into major biological discoveries and clinical innovations that would help to alleviate cancer disparities in the US. We propose in this P50 (PAR-20-305) to establish a SPORE program to conduct translational research focusing on Asians Americans, Native Hawaiians and Pacific Islanders (AANHPI), the fastest growing US minority, to initially address three cancers of particularly high relevance. Project 1 will address the high rates of hepatocellular carcinoma (HCC) in this population by implementing a randomized lifestyle intervention among AANHPI patients with non-alcoholic fatty liver (NAFLD) and by investigating mechanistic biomarkers (cell-free and leukocyte DNA methylation) that may also provide much needed clinical management tools. We will test the efficacy of intermittent vs. continuous energy restriction to reverse the progression of NAFLD in AANHPI, the most common etiology of chronic liver disease and liver cancer in this population. Project 2 will address the excess lung cancer burden experienced by Native Hawaiians by developing a risk-based and culturally-informed lung cancer screening strategy, and investigate the mutation, methylation and transcriptomic profiles of lung squamous cell and small cell carcinomas and adenocarcinomas that contribute to the unexplained poor survival in this vulnerable population. Project 3 will address the very high breast cancer burden of Native Hawaiians and the rising rates in Asian Americans by testing the adequacy of current radiomic risk prediction algorithms for predicting breast cancer in these populations and by investigating related molecular and histopathologic features of breast tumor environment which may be related to visceral adiposity and have prognostic significance. We will also establish: 1) an Administrative Core with strategic planning, advisory and evaluation components; 2) an Outreach and Recruitment Core (ORC) facilitating studies among minorities; 3) a centralized biorepository of paired fresh-frozen tumor and blood samples, as well as archival tumor blocks (Pathology & Biospecimen Core); 4) a Biostatistics & Bioinformatics Core; 5) a Developmental Research Program to fund innovative pilot studies and a Career Enhancement Program to support promising investigators new to translational research; and 6) new collaborations, with other institutions for the further translation of our findings. The successful completion of this grant will significantly advance our ability to reduce the high burden of liver, lung and breast cancers in AANHPI and to conduct other innovative translational minority health research that will benefit Hawai`i, the Pacific region and the rest of the US.

项目概要/摘要 健康差异的根源在于生物、行为、社会文化和文化方面存在的多样性。 个人和人群的环境特征。夏威夷为少数族裔提供绝佳机会 健康研究因其独特的多样化人口、不同的癌症负担以及高质量的健康状况 护理和癌症登记。夏威夷大学癌症中心在利用 夏威夷的多民族人口研究癌症风险和结果的种族/民族差异。它建造了一个 面向社区的基础设施，将这些发现转化为重大生物学发现和临床 有助于缩小美国癌症差异的创新。我们在此 P50 (PAR-20-305) 中建议 建立 SPORE 计划，开展针对亚裔美国人、夏威夷原住民的转化研究 太平洋岛民 (AANHPI) 是美国增长最快的少数族裔，最初致力于解决三种癌症，特别是 相关性高。项目 1 将通过以下方式解决该人群中肝细胞癌 (HCC) 的高发病率问题： 对患有非酒精性脂肪肝 (NAFLD) 的 AANHPI 患者实施随机生活方式干预 并通过研究机械生物标志物（无细胞和白细胞 DNA 甲基化）也可以提供 急需的临床管理工具。我们将测试间歇性与连续性能量限制的功效 逆转 AANHPI 中 NAFLD 的进展，AANHPI 是慢性肝病和肝脏疾病最常见的病因 该人群中的癌症。项目 2 将解决夏威夷原住民所经历的过度肺癌负担 通过制定基于风险和文化背景的肺癌筛查策略，并研究突变， 肺鳞状细胞癌、小细胞癌和腺癌的甲基化和转录组谱 这导致了这一弱势群体无法解释的生存状况不佳。项目 3 将解决非常高的问题 通过测试是否充足，了解夏威夷原住民的乳腺癌负担和亚裔美国人的发病率上升情况 当前用于预测这些人群中乳腺癌的放射组学风险预测算法并通过调查 乳腺肿瘤环境的相关分子和组织病理学特征可能与内脏相关 肥胖并具有预后意义。我们还将建立：1）具有战略意义的行政核心 规划、咨询和评估部分； 2) 外展和招聘核心（ORC）促进 少数民族研究； 3) 配对的新鲜冷冻肿瘤和血液样本的集中生物储存库，以及 作为档案肿瘤块（病理学和生物样本核心）； 4) 生物统计学和生物信息学核心； 5）一个 资助创新试点研究的发展研究计划和职业提升计划 支持有前途的转化研究新研究者； 6) 与其他机构的新合作 进一步转化我们的发现。这笔赠款的成功完成将极大地推进我们的 有能力减轻 AANHPI 中肝癌、肺癌和乳腺癌的高负担并进行其他创新 转化性少数族裔健康研究将使夏威夷、太平洋地区和美国其他地区受益。