Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model
评估果蝇肿瘤模型中肿瘤诱发的肌肉恶病质是否是由肌球蛋白重链产生和定位缺陷引发的
基本信息
- 批准号:10715061
- 负责人:
- 金额:$ 16.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-15 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAutomobile DrivingBasic ScienceBody WeightBody partCachexiaCancer EtiologyCancer ModelCancer PatientCellsCellular StressCessation of lifeChronicClinicClinicalCommunitiesComplexCoupledDataDefectDevelopmentDiagnosisDiagnosticDietary InterventionDiseaseDistantDrosophila genusEarly DiagnosisEndocrineEthicsEventFamily memberFatty acid glycerol estersFoundationsFutureGeneticGoalsImageImmune System DiseasesInterventionLaboratoriesLarvaLearningMalignant NeoplasmsMaster of ScienceMetabolicMicrotubulesModelingMolecular ChaperonesMusMuscleMuscle FibersMuscle WeaknessMuscular AtrophyMyosin ATPaseMyosin Heavy ChainsMyosin Light ChainsNamesNuclearOrganOutcomePathologyPathway interactionsPatientsPhenotypeProcessProductionPublishingQuality of lifeRefractoryResearchResearch PersonnelResolutionSarcomeresSignal PathwaySpeedStainsStereotypingStressStudentsSyndromeSystemSystemic diseaseTestingTimeTissuesTrainingWorkcancer cachexiacarcinogenesiscostgenetic approachgenetic manipulationin vivoinsightmouse modelnovelpreventprogramsprotein foldingprotein transportpsychologicresponseskeletal muscle wastingtooltranscriptomicstumorundergraduate studentwasting
项目摘要
PI: Mardelle Atkins
Commons ID: MRATKINS
Abstract: Assessing if tumor induced muscle cachexia is initiated by defects in Myosin
Heavy Chain production and localization in a Drosophila tumor model
Cachexia is a devastating cancer associated disease which affects millions each year
and yet is untreatable. Currently cachexia is defined in patients by rapid loss of >5% of
body weight with muscle weakness and an underlying chronic condition. Cachexia is
considered a late stage consequence of cancer. Here, we present preliminary data
acquired by undergraduate students using a Drosophila model of cancer cachexia.
Excitingly, we have identified stereotyped changes which occur in vivo early in tumor
development. In this study we will distinguish the origins of these phenotypes, assess
their contribution to cachexia progression, and investigate if the Hippo signaling
pathway is regulating early or late events in cachexia.We will leverage our expertise in
staining and imaging as well as new community tools which allow tissue specific genetic
manipulation to achieve our goals. These works, conducted by underrepresented
undergraduate researchers and master’s students will shed light on the unknown
etiology of cancer induced cachexia. Results of these, and future translational works,
are the foundation to developing earlier diagnostics permitting interventions to prevent
cachexic progression in patients. Through the course of this support the PI will establish
an independent research program which will illuminate the earliest steps of cachexic
changes in muscles and provide critical training and support to underrepresented
trainees.
PI:玛黛尔·阿特金斯
项目成果
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Mardelle Renee Atkins其他文献
Mardelle Renee Atkins的其他文献
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