Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model

评估果蝇肿瘤模型中肿瘤诱发的肌肉恶病质是否是由肌球蛋白重链产生和定位缺陷引发的

• 批准号: 10715061
• 负责人: Mardelle Renee Atkins
• 金额: $ 16.99万
• 依托单位: SAM HOUSTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10715061
• 关键词: Affect; Automobile Driving; Basic Science; Body Weight; Body part; Cachexia; Cancer Etiology; Cancer Model; Cancer Patient; Cells; Cellular Stress; Cessation of life; Chronic; Clinic; Clinical; Communities; Complex; Coupled; Data; Defect; Development; Diagnosis; Diagnostic; Dietary Intervention; Disease; Distant; Drosophila genus; Early Diagnosis; Endocrine; Ethics; Event; Family member; Fatty acid glycerol esters; Foundations; Future; Genetic; Goals; Image; Immune System Diseases; Intervention; Laboratories; Larva; Learning; Malignant Neoplasms; Master of Science; Metabolic; Microtubules; Modeling; Molecular Chaperones; Mus; Muscle; Muscle Fibers; Muscle Weakness; Muscular Atrophy; Myosin ATPase; Myosin Heavy Chains; Myosin Light Chains; Names; Nuclear; Organ; Outcome; Pathology; Pathway interactions; Patients; Phenotype; Process; Production; Publishing; Quality of life; Refractory; Research; Research Personnel; Resolution; Sarcomeres; Signal Pathway; Speed; Stains; Stereotyping; Stress; Students; Syndrome; System; Systemic disease; Testing; Time; Tissues; Training; Work; cancer cachexia; carcinogenesis; cost; genetic approach; genetic manipulation; in vivo; insight; mouse model; novel; prevent; programs; protein folding; protein transport; psychologic; response; skeletal muscle wasting; tool; transcriptomics; tumor; undergraduate student; wasting

PI: Mardelle Atkins Commons ID: MRATKINS Abstract: Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model Cachexia is a devastating cancer associated disease which affects millions each year and yet is untreatable. Currently cachexia is defined in patients by rapid loss of >5% of body weight with muscle weakness and an underlying chronic condition. Cachexia is considered a late stage consequence of cancer. Here, we present preliminary data acquired by undergraduate students using a Drosophila model of cancer cachexia. Excitingly, we have identified stereotyped changes which occur in vivo early in tumor development. In this study we will distinguish the origins of these phenotypes, assess their contribution to cachexia progression, and investigate if the Hippo signaling pathway is regulating early or late events in cachexia.We will leverage our expertise in staining and imaging as well as new community tools which allow tissue specific genetic manipulation to achieve our goals. These works, conducted by underrepresented undergraduate researchers and master’s students will shed light on the unknown etiology of cancer induced cachexia. Results of these, and future translational works, are the foundation to developing earlier diagnostics permitting interventions to prevent cachexic progression in patients. Through the course of this support the PI will establish an independent research program which will illuminate the earliest steps of cachexic changes in muscles and provide critical training and support to underrepresented trainees.

PI：玛黛尔·阿特金斯