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The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care (CITEC)

公平癌症护理护理点技术创新与转化中心 (CITEC)

基本信息

批准号：
10715740
负责人：
Sharmila Anandasabapathy
金额：
$ 130万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-13 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10715740
关键词：
Acceleration Accounting Address Adoption Anus Award Brazil Cancer Detection Cancer Hospital Cancer Patient Caring Cervix Uteri Cessation of life Clinical Collaborations Colon Communities Complex Country Dedications Development Diagnosis Disease Disparity Diverse Workforce Early Diagnosis Early treatment Engineering Ensure Epithelium Equity Esophagus Evaluation Gastrointestinal tract structure Goals Health Health Sciences Human Development Incidence Industrialization Infrastructure Lesion Malignant Neoplasms Medically Underserved Area Medicine Mozambique Oral cavity Organ Outcome Pain Palliative Care Performance Point of Care Technology Prevention Prevention approach Prevention program Primary Care Process Productivity Public Health Recommendation Rectum Research Research Personnel Resource-limited setting Resources Rice Scientist Screening for cancer Site Stomach Suggestion Surface Sustainable Development Technology Testing Texas Training Translating Translations United States National Institutes of Health Universities University of Texas M D Anderson Cancer Center Work World Health Organization anticancer research cancer care cancer health disparity cancer prevention cancer therapy cancer type college commercialization cost disparity reduction ethnic minority implementation barriers improved improved outcome indexing innovation low and middle-income countries medically underserved medically underserved population meetings member mortality new technology novel personalized approach point of care point of care testing premalignant premature preventable death prevention service primary care setting prototype racial minority rectal screening technology development technology research and development tool training opportunity underserved community usability

项目摘要

Abstract: Cancer is the first or second leading cause of premature death in 134 of 183 countries, and it is estimated that global incidence of cancer will increase by 50% from 2018 to 2040. The number of cases is projected to double in countries with low Human Development Index; these countries have the least resources and infrastructure to adequately care for cancer patients. Disparities exist within countries; in the US, racial and ethnic minorities and other medically underserved populations share a disproportionate burden for many types of cancer. Most cancers can be cured if detected early and treated effectively. To reduce premature death, the World Health Organization recommends implementing early cancer detection and prevention programs at the primary care level. Yet, existing tests for early cancer detection are too complex and/or expensive to implement in primary care settings, particularly in medically underserved areas. We will establish the Center for Innovation and Translation of Point-of-Care Technologies for Equitable Cancer Care (CITEC) to identify high- priority clinical needs for POC cancer technologies; to accelerate development of effective, affordable technologies to meet these needs; to evaluate and improve the clinical and public health impact of POC technologies in diverse settings; and to train developers and users to create and disseminate more equitable POC technologies. CITEC will prioritize development of POC tests to detect cancers that arise in epithelial surfaces. Initially, we will focus on sites accessible for early detection because this is where POC technologies can have the most immediate impact. Targeted organ sites include the uterine cervix, gastro-intestinal tract (esophagus, stomach, colon, rectum, anus), and oral cavity; cancers in these sites account for 26% of global cases and 29% of global cancer deaths. CITEC builds on the highly productive 15-year collaboration between Rice University, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, and The University of Texas Health Science Center at Houston to develop and translate novel POC technologies to improve cancer care in both low- and high-resource settings. Joining with collaborators in Brazil at The University of Sao Paulo and Barretos Cancer Hospital and partners in Mozambique at The Universidade Eduardo Mondlane and Ministry of Health, we will create a collaborative center to support technology development and engage and support a global community of investigators dedicated to creating and scaling POC technologies for equitable cancer screening and diagnosis to facilitate early treatment. CITEC will support development of POC technologies to promote high priority topics of NIH cancer research, including precision approaches to prevention, screening and early detection, reducing disparities in cancer outcomes, and building a diverse workforce able to translate POC technologies from research and development to equitable implementation. CITEC will have a major impact on equitable prevention, diagnosis and early treatment of cancer in the US and worldwide, and will work with the POCTRN network to build a strong team of global partners to strengthen and sustain POC technology development.

抽象的：在 183 个国家中的 134 个国家中，癌症是导致过早死亡的第一或第二大原因，据估计，全球从 2018 年到 2040 年，癌症发病率将增加 50%。在癌症国家，癌症病例数预计将增加一倍人类发展指数低；这些国家拥有最少的资源和基础设施来充分护理癌症患者。国家内部存在差异；在美国，少数族裔和其他医疗服务不足的人人口对多种类型的癌症承担着不成比例的负担。如果及早发现，大多数癌症都可以治愈得到有效治疗。为了减少过早死亡，世界卫生组织建议实施早期癌症治疗初级保健层面的检测和预防计划。然而，现有的早期癌症检测测试过于复杂和/或在初级保健机构中实施成本高昂，特别是在医疗服务不足的地区。我们将建立公平癌症护理即时护理技术创新与转化中心 (CITEC) 旨在确定高 POC 癌症技术的优先临床需求；加速开发有效、负担得起的技术满足这些需求；评估和改善 POC 技术在不同环境中的临床和公共卫生影响；培训开发者和用户创建和传播更公平的 POC 技术。 CITEC将优先考虑开发 POC 测试来检测上皮表面出现的癌症。最初，我们将重点关注可访问的网站及早发现，因为这是 POC 技术可以产生最直接影响的地方。目标器官部位包括子宫颈、胃肠道（食道、胃、结肠、直肠、肛门）和口腔；这些部位的癌症占全球癌症病例的 26% 和全球癌症死亡人数的 29%。 CITEC 建立在 15 年高产的基础上莱斯大学、德克萨斯大学 MD 安德森癌症中心、贝勒医学院、与德克萨斯大学休斯敦健康科学中心合作开发和转化新型 POC 技术，以改善资源匮乏和资源丰富环境中的癌症护理。与巴西圣保罗大学的合作者一起巴雷托斯癌症医院以及莫桑比克爱德华多·蒙德拉内大学和卫生部的合作伙伴，我们将创建一个协作中心来支持技术开发并参与和支持全球社区研究人员致力于创建和扩展 POC 技术，以实现公平的癌症筛查和诊断，以促进及早治疗。 CITEC 将支持 POC 技术的开发，以促进 NIH 癌症的高度优先主题研究，包括预防、筛查和早期检测的精确方法，减少癌症的差异成果，并建立一支多元化的员工队伍，能够将 POC 技术从研发转化为公平执行。 CITEC 将对公平预防、诊断和早期治疗产生重大影响并将与 POCTRN 网络合作，建立一支强大的全球合作伙伴团队，加强和维持POC技术的发展。