Academic-Industrial Partnership to Develop & Test Esophageal Cancer Imaging Tools

发展学术与工业合作伙伴关系

• 批准号: 8839486
• 负责人: Sharmila Anandasabapathy
• 金额: $ 17.42万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-16 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8839486
• 关键词: Algorithmic Analysis; Algorithmic Software; Algorithms; Area; Atlases; Barrett Esophagus; Benign; Biopsy; Bladder; Blood Vessels; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Colon; Communities; Computer software; Data Analyses; Data Set; Detection; Development; Devices; Diagnosis; Diagnostic Specificity; Disease; Dyes; Dysplasia; Early Diagnosis; Early treatment; Endoscopes; Endoscopy; Ensure; Epithelium; Esophageal; Esophageal Adenocarcinoma; Esophageal Tissue; Esophagectomy; Evaluation; Excision; Fluorescence; Future; Goals; Histopathology; Image; Image Analysis; Imaging Device; Incidence; Individual; Inflammatory; Knowledge; Learning; Lesion; Light; Lighting; Malignant Neoplasms; Malignant neoplasm of esophagus; Medical; Methods; Microinvasive; Microscopic; Microscopy; Modality; Morbidity - disease rate; Mucous Membrane; Multimodal Imaging; Neoplasms; Normal Range; Nuclear; Online Systems; Operative Surgical Procedures; Optics; Organ; Patients; Performance; Population; Population Surveillance; Premalignant; Property; Resolution; Resources; Rice; Risk; Screening for cancer; Sensitivity and Specificity; Site; Specificity; Specimen; Staging; Stomach; Sum; Surface; System; Technology; Testing; Time; Topical application; Training; Training and Education; Translating; Translations; Universities; Visual; Work; base; cancer imaging; clinical practice; cost; design; diagnostic accuracy; digital; digital imaging; experience; fluorescence imaging; high risk; imaging modality; improved; indexing; mortality; neoplastic; novel; optical imaging; prototype; research clinical testing; screening; standard of care; tool

DESCRIPTION (provided by applicant): Esophageal adenocarcinoma (EAC) has one of the fastest rising rates of incidence in the US. Unfortunately, the five-year-survival for patients diagnosed with EAC is only 10%. EAC develops primarily in patients with Barrett's esophagus (BE). Endoscopic screening and biopsy is recommended for at-risk individuals. However, standard white-light endoscopic examination frequently misses areas of early neoplasia, which are often clinically indistinguishable from normal mucosa and/or inflammatory changes. Studies have shown that as many as 43-57% of early cancers can be missed by this method. Thus, there is an important need for new endoscopic technologies which improve the ability of clinicians to identify precancerous lesions and early cancers with high sensitivity and specificity. The goal of this proposal is to develop, optimize and validate novel multi-modal, multi-scale optical imaging platforms for non-invasive, early detection of esophageal neoplasia based on optical imaging. We will collaborate with colleagues at Pentax, Inc. to design and test multi-modal endoscopic imaging systems for early detection of neoplasia in Barrett's esophagus. Widefield endoscopic imaging will be used initially to screen the surface area at risk to identify abnormal sites with high sensitivity; suspicious areas will then be imaged with much higher spatial resolution to achieve high diagnostic specificity. Both wide field and high resolution technologies will be integrated into a single endoscopic platform to increase the ease and accuracy of endoscopic cancer screening and surveillance. In sequential clinical studies, we will first separately optimize the performance of wide field endoscopic imaging and high resolution imaging. We will then integrate the wide field and high resolution imaging systems and validate their accuracy for the detection of neoplasia in subjects with Barrett's esophagus, the precursor to esophageal adenocarcinoma. Lastly, we will develop an image atlas of typical wide-field and high-resolution images, interpretation criteria, and histopathology to train future users and serve as an educational resource.

描述（由申请方提供）：食管腺癌（EAC）是美国发病率上升最快的疾病之一。不幸的是，诊断为EAC的患者的五年生存率仅为10%。EAC主要发生在Barrett食管（BE）患者中。内镜筛查和活组织检查是建议在风险的个人。然而，标准的白光内窥镜检查经常错过早期肿瘤形成的区域，这些区域通常在临床上与正常粘膜和/或炎症变化无法区分。研究表明，这种方法可以遗漏多达43-57%的早期癌症。因此，迫切需要新的内窥镜技术，以提高临床医生以高灵敏度和特异性识别癌前病变和早期癌症的能力。该提案的目标是开发、优化和验证新型多模态、多尺度光学成像平台，用于基于光学成像的食管肿瘤的非侵入性早期检测。我们将与宾得公司的同事合作。设计和测试多模式内窥镜成像系统，用于早期检测Barrett食管中的肿瘤。最初将使用宽视野内窥镜成像来筛查有风险的表面区域，以高灵敏度识别异常部位;然后将以更高的空间分辨率对可疑区域进行成像，以实现高诊断特异性。宽视野和高分辨率技术将被集成到一个单一的内窥镜平台，以提高内窥镜癌症筛查和监测的简便性和准确性。在后续临床研究中，我们将首先分别优化宽视野内窥镜成像和高分辨率成像的性能。然后，我们将整合宽视场和高分辨率成像系统，并验证其在Barrett食管（食管腺癌的前体）受试者中检测肿瘤的准确性。最后，我们将开发一个典型的宽视场和高分辨率图像，解释标准和组织病理学的图像图集，以培训未来的用户，并作为教育资源。

项目成果

Optimizing modulation frequency for structured illumination in a fiber-optic microendoscope to image nuclear morphometry in columnar epithelium.

• DOI: 10.1364/boe.6.000870
• 发表时间: 2015-03
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: P. Keahey;T. Tkaczyk;Kathleen M Schmeler;R. Richards-Kortum

Optical molecular imaging in the gastrointestinal tract.

胃肠道光学分子成像。

• DOI: 10.1016/j.giec.2013.03.010
• 发表时间: 2013
• 期刊: Gastrointestinal endoscopy clinics of North America
• 作者: Carns,Jennifer;Keahey,Pelham;Quang,Timothy;Anandasabapathy,Sharmila;Richards-Kortum,Rebecca
• 通讯作者: Richards-Kortum,Rebecca

In vivo white light and contrast-enhanced vital-dye fluorescence imaging of Barrett's-related neoplasia in a single-endoscopic insertion.

单次内窥镜插入中巴雷特相关肿瘤的体内白光和对比增强活体染料荧光成像。

• DOI: 10.1117/1.jbo.21.8.086004
• 发表时间: 2016
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Tang,Yubo;Carns,Jennifer;Polydorides,AlexandrosD;Anandasabapathy,Sharmila;Richards-Kortum,RebeccaR
• 通讯作者: Richards-Kortum,RebeccaR

Use of in vivo real-time optical imaging for esophageal neoplasia.

使用体内实时光学成像治疗食管肿瘤。

• DOI: 10.1002/msj.20304
• 发表时间: 2011
• 期刊: The Mount Sinai journal of medicine, New York
• 作者: Vila,PeterM;Thekkek,Nadhi;Richards-Kortum,Rebecca;Anandasabapathy,Sharmila
• 通讯作者: Anandasabapathy,Sharmila

Diagnosis of neoplasia in Barrett's esophagus using vital-dye enhanced fluorescence imaging.

使用活体染料增强荧光成像诊断巴雷特食管肿瘤。

• DOI: 10.3791/50992
• 发表时间: 2014
• 期刊: Journal of visualized experiments : JoVE
• 作者: Perl,DanielP;Parikh,Neil;Chang,Shannon;Peng,Paul;Thekkek,Nadhi;Lee,MichelleH;Polydorides,AlexandrosD;Mitcham,Josephine;Richards-Kortum,Rebecca;Anandasabapathy,Sharmila
• 通讯作者: Anandasabapathy,Sharmila