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Development and Application of T1rho Dispersion Imaging of Aging Muscle

衰老肌肉T1rho色散成像的开发与应用

基本信息

批准号：
10714064
负责人：
Fatemeh Adelnia
金额：
$ 7.59万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10714064
关键词：
3-Dimensional APP-PS1 Adopted Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Amyloid beta-Protein Anatomy Animal Model Animals Autopsy Award Basal lamina Behavioral Biological Biological Markers Blood Vessels Blood capillaries Brain Capillarity Clinical Clinical Research Cognition Cognitive Data Dementia Detection Development Elderly Evaluation Extracellular Matrix Proteins Frequencies Goals Grant Histology Human Image Imaging Techniques Impaired cognition Individual Linear Regressions Longevity Magnetic Resonance Imaging Mass Spectrum Analysis Matched Group Measurement Measures Methods Molecular Neurofibrillary Tangles Neuropsychology Normal Range Participant Pathogenesis Pathologic Processes Patients Predisposition Protocols documentation Relaxation Reporting Research Risk Role Rotation Sample Size Senile Plaques Structure Techniques Tissues Variant Width Wild Type Mouse aging brain behavior test biomarker validation brain tissue clinical diagnosis clinical practice clinical translation cognitive testing cohort deoxyhemoglobin imaging modality improved in vivo indexing innovation insight interest magnetic resonance imaging biomarker mild cognitive impairment mouse model muscle aging normal aging novel parent grant protein distribution recruit response sex tau Proteins tool water diffusion white matter

项目摘要

Summary / Abstract This supplement aims to extend the goals and impact of research being undertaken by award #1K25AG076864-01 “Development and Application of T1rho Dispersion Imaging of Aging Muscle” to quantify degenerative changes in brain tissues associated with the progression of Alzheimer’s Disease (AD). The aims of our current parent grant are to adapt and validate magnetic resonance imaging (MRI) methods that exploit novel contrast mechanisms based on variations of R1ρ (R1ρ =1/T1ρ -the rotating frame spin-lattice relaxation rates) with changing the locking field frequencies, which provide new ways to detect changes in tissue, quantify intrinsic micro-structural features such as vascular spacing, and improve the ability to discriminate pathological processes. This supplement will specifically be used to quantify and validate changes in microvasculature and molecular composition associated with degenerative changes in brain tissues associated with the onset of dementia using animal models. To achieve these goals, we validate the interpretation of MRI parameters in terms of pathophysiological changes via gold-standard methods, including histology and imaging mass spectroscopy. The adapted T1ρ sequence and conventional MRI measurements also will be evaluated in a large cohort of older adults (+60 years), including patients with mild cognitive impairment (MCI), AD, and age- matched controls using a clinical 3T MR scanner. Clinical diagnosis and cognitive behavioral tests will be used to determine the cognitive level of each participant. We predict that application of this MRI protocol will characterize the changes in composition and microvasculature that accompany the progression towards AD in correlation with cognitive index scores, with special relevance to changes in white matter. Relevance to AD: The insights provided by these studies will provide new ways to extract information on tissue composition and microstructure using R1ρ weighted acquisitions with specific applications in AD. The supplement would support the extension of an exciting and highly innovative method of quantifying changes in brain structure and microvasculature in aging brains and provide new, quantitative biomarkers of the changes that occur during cognitive decline and the onset of Alzheimer’s Disease and transition to dementia.

总结/摘要这一补充的目的是扩大目标和影响的研究正在进行的奖励 #1K25AG076864 - 01 "老化肌肉T1rho弥散成像的开发和应用"，以量化与阿尔茨海默病（AD）进展相关的脑组织退行性变化。目标我们目前的母基金是适应和验证磁共振成像（MRI）的方法，利用基于R1 ρ（R1 ρ = 1/T1 ρ-旋转坐标系自旋-晶格弛豫）变化的新对比机制速率），这提供了检测组织变化的新方法，固有的微结构特征，如血管间距，并提高区分病理的能力，流程.该补充将专门用于量化和验证微血管系统的变化，与脑组织退行性变化相关的分子组成，痴呆症的动物模型。为了实现这些目标，我们验证了MRI参数的解释，通过金标准方法的病理生理学变化术语，包括组织学和成像质量谱调整后的T1 ρ序列和常规MRI测量也将在大型老年人队列（+60岁），包括轻度认知障碍（MCI）、AD和年龄- 使用临床3T MR扫描仪匹配对照。将使用临床诊断和认知行为测试以确定每个参与者的认知水平。我们预测，这种MRI协议的应用将表征伴随AD进展的组成和微血管系统的变化，与认知指数评分相关，与白色物质变化特别相关。与AD的相关性：这些研究提供的见解将为提取以下信息提供新的方法：组织成分和微观结构，使用R1 ρ加权采集，在AD中具有特定应用。的补充将支持扩展一个令人兴奋的和高度创新的量化变化的方法，脑结构和微血管系统的变化，并提供新的定量生物标志物的变化，发生在认知能力下降和阿尔茨海默病的发病以及向痴呆症的转变过程中。