Structural studies on dynein-microtubule complex

动力蛋白-微管复合物的结构研究

• 批准号: 7163426
• 负责人: William J Snell
• 金额: $ 22.87万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7163426
• 关键词: ATP Hydrolysis; Address; Amyotrophic Lateral Sclerosis; Axonal Transport; Beauty; Binding; Binding Sites; Biochemical; Biological Assay; Blur; Calcium; Chemicals; Chlamydomonas; Chromosome Segregation; Cilia; Complex; Cryoelectron Microscopy; Cytoskeletal Filaments; Disease; Dissociation; Distal; Dynein ATPase; Figs - dietary; Generations; Genetic; Goals; Head; Health; Helix (Snails); Human; Hydrolysis; Image Analysis; In Vitro; Individual; Kinesin; Laboratories; Little' s Disease; Location; Mechanics; Microtubules; Modeling; Motion; Motor; Movement; Mutation; Myosin ATPase; Nucleotides; Primary Ciliary Dyskinesias; Proteins; Recombinants; Regulation; Relative (related person); Research; Research Personnel; Resolution; Role; Structure; System; Techniques; Upper arm; base; cell motility; ear helix; high throughput analysis; in vivo; nanomachine; nanoscale; programs; reconstruction; size; stem; three dimensional structure

项目成果

Molecular determination by electron microscopy of the dynein-microtubule complex structure.

通过电子显微镜对动力蛋白-微管复合物结构进行分子测定。

• DOI: 10.1016/j.jmb.2007.07.046
• 发表时间: 2007
• 期刊: Journal of molecular biology
• 影响因子: 5.6
• 作者: Narita,Akihiro;Mizuno,Naoko;Kikkawa,Masahide;Maeda,Yuichiro
• 通讯作者: Maeda,Yuichiro

Three-dimensional structure of cytoplasmic dynein bound to microtubules

• DOI: 10.1073/pnas.0710406105
• 发表时间: 2007-12-26
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Mizuno, Naoko;Narita, Akihiro;Kikkawa, Masahide
• 通讯作者: Kikkawa, Masahide